ENSP00000380019 (Macaca fascicularis)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00096 (zf-C2H2) IPR007087 ENSP00000380019 T135431_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Apr 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ZNF384
M04451_2.00 		Homo sapiens
TTTTBNNNNNNNNNNNNVAAAA
TTTTBNNNNNNNNNNNNVAAAA		 SELEX
Yin et al.(2017)
ZNF384_eDBD_HT-SELEX 		0.798 0.989
ZNF384
M08306_2.00 		Homo sapiens
CTTTTTTTT
AAAAAAAAG		 ChIP-seq
Schmitges et al.(2016)
Q8TF68_1-3.RCADE 		0.798 0.989
ZNF384
M08090_2.00 		Homo sapiens
WTTTTTTTNHNN
NNDNAAAAAAAW		 ChIP-seq
Mathelier et al.(2014)
MA1125.1 		0.798 0.989
ZNF384
M08888_2.00 		Homo sapiens
BVNNBTTTTTSC
GSAAAAAVNNBV		 Misc
Kulakovskiy et al.(2013)
ZN384_HUMAN.H11MO.0.C 		0.798 0.989
ZNF384
M10209_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$CIZ_01 		0.798 0.989
ZNF384
M04452_2.00 		Homo sapiens
KTTTYHNNNNNNNNNNDRAAAV
BTTTYHNNNNNNNNNNDRAAAM		 SELEX
Yin et al.(2017)
ZNF384_eDBD_Methyl-HT-SELEX 		0.798 0.989
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000380019 C2H2 ZF 228 250
ENSP00000380019 C2H2 ZF 256 278
ENSP00000380019 C2H2 ZF 284 306
ENSP00000380019 C2H2 ZF 317 339
ENSP00000380019 C2H2 ZF 345 367
ENSP00000380019 C2H2 ZF 373 397
ENSP00000380019 C2H2 ZF 403 425
ENSP00000380019 C2H2 ZF 433 455

Links

Other C2H2 ZF family TFs
Other Macaca fascicularis TFs

Invalid Input OrderBy

37 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action