ENSP00000380480-D1 (Bos grunniens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00096 (zf-C2H2) IPR007087 ENSP00000380480-D1 T135445_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
ZNF891
M07762_2.00
Homo sapiens
NNNBNNNNSNGRCWKCYAGCC

GGCTRGMWGYCNSNNNNVNNN
ChIP-seq+ChIP-exo
Barazandeh et al.(2018)
ZNF891.RCADE.ReprocessedData
0.778 0.891
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000380480-D1 C2H2 ZF 321 343
ENSP00000380480-D1 C2H2 ZF 349 371
ENSP00000380480-D1 C2H2 ZF 377 399
ENSP00000380480-D1 C2H2 ZF 405 427
ENSP00000380480-D1 C2H2 ZF 433 455
ENSP00000380480-D1 C2H2 ZF 461 483
ENSP00000380480-D1 C2H2 ZF 489 511
ENSP00000380480-D1 C2H2 ZF 517 539

Links

Other C2H2 ZF family TFs
Other Bos grunniens TFs

7 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSNLEG00000019147 Nomascus leucogenys ENSNLEG00000019147 I 0.788
ENSP00000380480 Macaca fascicularis ENSP00000380480 I 0.788
ZNF891 Callithrix jacchus ENSCJAG00000023027 I 0.788
ZNF891 Macaca mulatta ENSMMUG00000031445 I 0.788
ZNF891 Homo sapiens ENSG00000214029 D 0.778
ZNF891 Pan troglodytes ENSPTRG00000034499 I 0.778
ZNF891 Gorilla gorilla ENSGGOG00000022474 I 0.776