ENSP00000384734-D2 (Bos grunniens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00096 (zf-C2H2) IPR007087 ENSP00000384734-D2 T135474_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
GLIS3
M02880_2.00
Homo sapiens
CTTYGTGGGGGGTM

KACCCCCCACRAAG
SELEX
Jolma et al.(2013)
GLIS3_1
0.825 0.982
GLIS3
M10169_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ZNF515_01
0.825 0.982
GLIS3
M10170_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ZNF515_Q6_01
0.825 0.982
GLIS3
M10171_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ZNF515_Q6
0.825 0.982
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000384734-D2 C2H2 ZF 375 400
ENSP00000384734-D2 C2H2 ZF 409 436
ENSP00000384734-D2 C2H2 ZF 443 466
ENSP00000384734-D2 C2H2 ZF 472 496
ENSP00000384734-D2 C2H2 ZF 502 526

Links

Other C2H2 ZF family TFs
Other Bos grunniens TFs

79 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
GLIS3 Vicugna pacos ENSVPAG00000005473 I 0.827
ENSOARG00000013378 Ovis aries ENSOARG00000013378 I 0.827
GLIS3 Otolemur garnettii ENSOGAG00000007376 I 0.825
GLIS3 Homo sapiens ENSG00000107249 D 0.825
ENSPSIG00000005966 Pelodiscus sinensis ENSPSIG00000005966 I 0.825
ENSPANG00000025157 Papio anubis ENSPANG00000025157 I 0.825
ENSOANG00000014997 Ornithorhynchus anatinus ENSOANG00000014997 I 0.825
ENSMPUG00000005095 Mustela putorius furo ENSMPUG00000005095 I 0.825
ENSMEUG00000005102 Macropus eugenii ENSMEUG00000005102 I 0.825
Glis3 Mus musculus ENSMUSG00000052942 I 0.825
ENSNLEG00000008824 Nomascus leucogenys ENSNLEG00000008824 I 0.825
GLIS3 Monodelphis domestica ENSMODG00000015403 I 0.825
GLIS3 Pteropus vampyrus ENSPVAG00000001839 I 0.825
GLIS3 Equus caballus ENSECAG00000020544 I 0.825
GLIS3 Callithrix jacchus ENSCJAG00000011083 I 0.825
ENSP00000371398 Macaca fascicularis ENSP00000371398 I 0.825
Myotis_brandtii_GLIS3_10023567 Myotis brandtii Myotis_brandtii_GLIS3_10023567 I 0.825
ENSTSYG00000000686 Tarsius syrichta ENSTSYG00000000686 I 0.825
GLIS3 Cavia porcellus ENSCPOG00000005523 I 0.825
ENSSTOG00000000302 Ictidomys tridecemlineatus ENSSTOG00000000302 I 0.825
Glis3 Rattus norvegicus ENSRNOG00000014768 I 0.825
GLIS3 Anolis carolinensis ENSACAG00000003374 I 0.824
GLIS3 Echinops telfairi ENSETEG00000015977 I 0.823
ENSLOCG00000012972 Lepisosteus oculatus ENSLOCG00000012972 I 0.822
ENSPPYG00000019250 Pongo abelii ENSPPYG00000019250 I 0.816
Ogr17806 Ophisaurus gracilis Ogr17806 I 0.816
Afo_R016063 Aptenodytes forsteri Afo_R016063 I 0.816
GLIS3 Procavia capensis ENSPCAG00000004139 I 0.816
GLIS3 Canis familiaris ENSCAFG00000031499 I 0.816
GLIS1 Cavia porcellus ENSCPOG00000009497 I 0.816
ENSLOCG00000003071 Lepisosteus oculatus ENSLOCG00000003071 I 0.816
ENSMEUG00000009882 Macropus eugenii ENSMEUG00000009882 I 0.816
ENSAPLG00000014844 Anas platyrhynchos ENSAPLG00000014844 I 0.816
GLIS3 Gallus gallus ENSGALG00000010180 I 0.815
glis3 Xenopus tropicalis XB-GENE-984727 I 0.815
Aan_R004381 Calypte anna Aan_R004381 I 0.814
Pvit_10484 Pogona vitticeps Pvit_10484 I 0.814
GLIS1 Tetraodon nigroviridis ENSTNIG00000010694 I 0.812
ENSXMAG00000013077 Xiphophorus maculatus ENSXMAG00000013077 I 0.812
ENSAMXG00000005278 Astyanax mexicanus ENSAMXG00000005278 I 0.812
glis1b Danio rerio ENSDARG00000027933 I 0.812
ENSTRUG00000001198 Takifugu rubripes ENSTRUG00000001198 I 0.812
ENSPFOG00000017914 Poecilia formosa ENSPFOG00000017914 I 0.812
ENSORLG00000003872 Oryzias latipes ENSORLG00000003872 I 0.812
GLIS1 Gasterosteus aculeatus ENSGACG00000012109 I 0.812
ENSGMOG00000018511 Gadus morhua ENSGMOG00000018511 I 0.812
SPU_018744 Strongylocentrotus purpuratus SPU_018744 I 0.810
GLIS3 Taeniopygia guttata ENSTGUG00000005266 I 0.810
ENSORLG00000007755 Oryzias latipes ENSORLG00000007755 I 0.809
ENSPFOG00000019805 Poecilia formosa ENSPFOG00000019805 I 0.809
ENSFALG00000010519 Ficedula albicollis ENSFALG00000010519 I 0.808
Sakowv30037345m.g Saccoglossus kowalevskii Sakowv30037345m.g I 0.807
ENSONIG00000014033 Oreochromis niloticus ENSONIG00000014033 I 0.807
Gfo_R012286 Geospiza fortis Gfo_R012286 I 0.807
gw.28.157.1 Branchiostoma floridae gw.28.157.1 I 0.805
e_gw.471.22.1 Branchiostoma floridae e_gw.471.22.1 I 0.805
ENSXMAG00000005013 Xiphophorus maculatus ENSXMAG00000005013 I 0.800
ENSXMAG00000005337 Xiphophorus maculatus ENSXMAG00000005337 I 0.794
ENSPFOG00000002618 Poecilia formosa ENSPFOG00000002618 I 0.794
glis1a Danio rerio ENSDARG00000068580 I 0.788
SMAR005079 Strigamia maritima SMAR005079 I 0.773
GLIS1 Pan troglodytes ENSPTRG00000000756 I 0.772
ENSAMXG00000019181 Astyanax mexicanus ENSAMXG00000019181 I 0.769
ENSGALG00000010721 Gallus gallus ENSGALG00000010721 I 0.769
Pvit_11533 Pogona vitticeps Pvit_11533 I 0.769
ENSPSIG00000002846 Pelodiscus sinensis ENSPSIG00000002846 I 0.769
ENSAPLG00000013972 Anas platyrhynchos ENSAPLG00000013972 I 0.769
Aan_R004053 Calypte anna Aan_R004053 I 0.769
ENSLACG00000012147 Latimeria chalumnae ENSLACG00000012147 I 0.769
Afo_R001041 Aptenodytes forsteri Afo_R001041 I 0.769
GLIS1 Meleagris gallopavo ENSMGAG00000011303 I 0.769
GLIS3 Erinaceus europaeus ENSEEUG00000004107 I 0.768
ENSFALG00000011974 Ficedula albicollis ENSFALG00000011974 I 0.767
Tal_R012308 Tyto alba Tal_R012308 I 0.767
GLIS1 Taeniopygia guttata ENSTGUG00000009294 I 0.767
DAPPUDRAFT_347217 Daphnia pulex DAPPUDRAFT_347217 I 0.767
Brh_R013214 Buceros rhinoceros Brh_R013214 I 0.767
Gfo_R010168 Geospiza fortis Gfo_R010168 I 0.767
ML145833a Mnemiopsis leidyi ML145833a I 0.756