ENSP00000398108-D1 (Bos grunniens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00096 (zf-C2H2) IPR007087 ENSP00000398108-D1 T135527_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
ZNF777
M05857_2.00
Homo sapiens
GHCCSYCCCGTCSARCAAW

WTTGYTSGACGGGRSGGDC
SMiLE-seq
Isakova et al.(2017)
ZNF777
0.827 0.995
ZNF777
M07703_2.00
Homo sapiens
CCGACGK

MCGTCGG
ChIP-seq+ChIP-exo
Barazandeh et al.(2018)
ZNF777.MEME.OriginalMapping
0.827 0.995
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000398108-D1 C2H2 ZF 186 208
ENSP00000398108-D1 C2H2 ZF 214 236
ENSP00000398108-D1 C2H2 ZF 277 299
ENSP00000398108-D1 C2H2 ZF 305 327
ENSP00000398108-D1 C2H2 ZF 335 357
ENSP00000398108-D1 C2H2 ZF 363 385
ENSP00000398108-D1 C2H2 ZF 391 413
ENSP00000398108-D1 C2H2 ZF 419 441
ENSP00000398108-D1 C2H2 ZF 447 469

Links

Other C2H2 ZF family TFs
Other Bos grunniens TFs

32 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ZNF777 Oryctolagus cuniculus ENSOCUG00000007975 I 0.827
ENSNLEG00000003719 Nomascus leucogenys ENSNLEG00000003719 I 0.827
Zfp777 Mus musculus ENSMUSG00000071477 I 0.827
ZNF777 Macaca mulatta ENSMMUG00000002497 I 0.827
ENSPANG00000023421 Papio anubis ENSPANG00000023421 I 0.827
ENSPPYG00000018155 Pongo abelii ENSPPYG00000018155 I 0.827
Zfp777 Rattus norvegicus ENSRNOG00000033639 I 0.827
ZNF777 Pteropus vampyrus ENSPVAG00000010873 I 0.827
ZNF777 Pan troglodytes ENSPTRG00000023754 I 0.827
ZNF777 Sus scrofa ENSSSCG00000016775 I 0.827
ENSSTOG00000027760 Ictidomys tridecemlineatus ENSSTOG00000027760 I 0.827
ZNF777 Callithrix jacchus ENSCJAG00000032232 I 0.827
ZNF777 Cavia porcellus ENSCPOG00000014359 I 0.827
ZNF777 Canis familiaris ENSCAFG00000025145 I 0.827
ZNF777 Bos taurus ENSBTAG00000002810 I 0.827
ENSAMEG00000002678 Ailuropoda melanoleuca ENSAMEG00000002678 I 0.827
ENSCSAG00000006994 Chlorocebus sabaeus ENSCSAG00000006994 I 0.827
ZNF777 Dasypus novemcinctus ENSDNOG00000003957 I 0.827
ZNF777 Gorilla gorilla ENSGGOG00000016445 I 0.827
ZNF777 Felis catus ENSFCAG00000007553 I 0.827
ZNF777 Homo sapiens ENSG00000196453 D 0.827
ENSP00000398108 Macaca fascicularis ENSP00000398108 I 0.823
ZNF777 Tursiops truncatus ENSTTRG00000015695 I 0.823
ZNF777 Myotis lucifugus ENSMLUG00000017103 I 0.814
Myotis_brandtii_ZNF777_10025635 Myotis brandtii Myotis_brandtii_ZNF777_10025635 I 0.814
ENSMEUG00000005929 Macropus eugenii ENSMEUG00000005929 I 0.812
ZNF777 Monodelphis domestica ENSMODG00000002329 I 0.810
ZNF777 Loxodonta africana ENSLAFG00000006716 I 0.808
ZNF777 Procavia capensis ENSPCAG00000003810 I 0.808
Cmyd_10002814 Chelonia mydas Cmyd_10002814 I 0.767
Pvit_14802 Pogona vitticeps Pvit_14802 I 0.759
ZNF777 Anolis carolinensis ENSACAG00000017661 I 0.759