ENSP00000399719 (Macaca fascicularis)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00096 (zf-C2H2) IPR007087 ENSP00000399719 T135531_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
GFI1
M00238_2.00
Homo sapiens
NWAWMNNNN

NNNNKWTWN
PBM
Barrera et al.(2016)
GFI1_REF
0.814 0.992
GFI1
M04507_2.00
Homo sapiens
BMAATCACDGCNHBBCACTMN

NKAGTGVVDNGCHGTGATTKV
SELEX
Yin et al.(2017)
GFI1_eDBD_HT-SELEX
0.814 0.992
Gfi1
M02668_2.00
Rattus norvegicus
NMAATCWVHS

SDBWGATTKN
SELEX
Mathelier et al.(2014)
MA0038.1
0.814 0.992
GFI1
M08905_2.00
Homo sapiens
MAATCWSWGY

RCWSWGATTK
Misc
Kulakovskiy et al.(2013)
GFI1_HUMAN.H11MO.0.C
0.814 0.992
Gfi1
M08984_2.00
Mus musculus
MAATCWSWGY

RCWSWGATTK
Misc
Kulakovskiy et al.(2013)
GFI1_MOUSE.H11MO.0.C
0.814 0.992
GFI1
M10235_2.00
Homo sapiens
NNNNNNNRCHSWGATTTDNNBNNN

NNNVNNHAAATCWSDGYNNNNNNN
Transfac
Matys et al.(2006)
V$GFI1_01
0.814 0.992
GFI1
M10236_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GFI1_Q6_01
0.814 0.992
GFI1
M04508_2.00
Homo sapiens
NNAGTGVVNHGCWSTGATTKV

BMAATCASWGCDNBBCACTNN
SELEX
Yin et al.(2017)
GFI1_eDBD_Methyl-HT-SELEX
0.814 0.992
GFI1
M00236_2.00
Homo sapiens
NAATMNNNN

NNNNKATTN
PBM
Barrera et al.(2016)
GFI1_L400F
0.812 0.985
GFI1
M00237_2.00
Homo sapiens
ATATCAVD

HBTGATAT
PBM
Barrera et al.(2016)
GFI1_N382S
0.777 0.985
GFI1B
M00240_2.00
Homo sapiens
NNAAATCWSDN

NHSWGATTTNN
PBM
Barrera et al.(2016)
GFI1B_REF
0.777 0.879
GFI1B
M04523_2.00
Homo sapiens
NMAATCASDGCNNBBCACTNN

NNAGTGVVNNGCHSTGATTKN
SELEX
Yin et al.(2017)
GFI1B_eDBD_HT-SELEX
0.777 0.879
Gfi1b
M08098_2.00
Mus musculus
MAATCWCWGCH

DGCWGWGATTK
ChIP-seq
Mathelier et al.(2014)
MA0483.1
0.777 0.879
GFI1B
M08909_2.00
Homo sapiens
MAATCWSDGY

RCHSWGATTK
Misc
Kulakovskiy et al.(2013)
GFI1B_HUMAN.H11MO.0.A
0.777 0.879
Gfi1b
M08977_2.00
Mus musculus
MAAYCACWGH

DCWGWGRTTK
Misc
Kulakovskiy et al.(2013)
GFI1B_MOUSE.H11MO.0.A
0.777 0.879
Gfi1b
M09514_2.00
Mus musculus
MAATCWSWGC

GCWSWGATTK
Misc
Heinz et al.(2010)
HPC7-Gfi1b_GSE22178
0.777 0.879
GFI1B
M10243_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GFI1B_01
0.777 0.879
GFI1B
M10244_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GFI1B_Q6
0.777 0.879
GFI1B
M04524_2.00
Homo sapiens
NMAATCASWGCDNNBCACTHN

NDAGTGVNNHGCWSTGATTKN
SELEX
Yin et al.(2017)
GFI1B_eDBD_Methyl-HT-SELEX
0.777 0.879
sens-2
M06165_2.00
Drosophila melanogaster
RYAAATCWSDGCAYNC

GNRTGCHSWGATTTRY
B1H
Zhu et al.(2011)
sens-2_SANGER_2.5_FBgn0051632
0.770 0.848
GFI1B
M00239_2.00
Homo sapiens
NNAAATCWSDN

NHSWGATTTNN
PBM
Barrera et al.(2016)
GFI1B_A204T
0.767 0.871
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000399719 C2H2 ZF 138 155
ENSP00000399719 C2H2 ZF 161 183
ENSP00000399719 C2H2 ZF 189 211
ENSP00000399719 C2H2 ZF 217 239
ENSP00000399719 C2H2 ZF 245 267
ENSP00000399719 C2H2 ZF 273 296

Links

Other C2H2 ZF family TFs
Other Macaca fascicularis TFs

137 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSBTAP00000022231-D1 Bos grunniens ENSBTAP00000022231-D1 I 0.825
GFI1 Loxodonta africana ENSLAFG00000018346 I 0.814
ENSMMUG00000005068 Macaca mulatta ENSMMUG00000005068 I 0.814
GFI1 Monodelphis domestica ENSMODG00000011802 I 0.814
GFI1 Gorilla gorilla ENSGGOG00000005320 I 0.814
GFI1 Homo sapiens ENSG00000162676 D 0.814
GFI1 Erinaceus europaeus ENSEEUG00000000198 I 0.814
GFI1 Felis catus ENSFCAG00000005914 I 0.814
ENSMPUG00000004178 Mustela putorius furo ENSMPUG00000004178 I 0.814
ENSNLEG00000010470 Nomascus leucogenys ENSNLEG00000010470 I 0.814
ENSSTOG00000014583 Ictidomys tridecemlineatus ENSSTOG00000014583 I 0.814
Ogr09401 Ophisaurus gracilis Ogr09401 I 0.814
gfi1 Xenopus tropicalis XB-GENE-960553 I 0.814
Gfi1 Rattus norvegicus ENSRNOG00000002042 D 0.814
ENSPANG00000016433 Papio anubis ENSPANG00000016433 I 0.814
GFI1 Dasypus novemcinctus ENSDNOG00000000782 I 0.814
GFI1 Otolemur garnettii ENSOGAG00000027913 I 0.814
Gfi1 Mus musculus ENSMUSG00000029275 D 0.814
GFI1 Ochotona princeps ENSOPRG00000001473 I 0.814
GFI1 Canis familiaris ENSCAFG00000020155 I 0.814
ENSAMEG00000013858 Ailuropoda melanoleuca ENSAMEG00000013858 I 0.814
GFI1 Anolis carolinensis ENSACAG00000004498 I 0.814
GFI1 Callithrix jacchus ENSCJAG00000017609 I 0.814
GFI1 Myotis lucifugus ENSMLUG00000015191 I 0.812
GFI1 Sus scrofa ENSSSCG00000006902 I 0.812
ENSGALG00000005940 Gallus gallus ENSGALG00000005940 I 0.812
GFI1 Meleagris gallopavo ENSMGAG00000008187 I 0.812
ENSONIG00000019246 Oreochromis niloticus ENSONIG00000019246 I 0.812
Tal_R006464 Tyto alba Tal_R006464 I 0.812
ENSAPLG00000015700 Anas platyrhynchos ENSAPLG00000015700 I 0.812
ENSLACG00000013362 Latimeria chalumnae ENSLACG00000013362 I 0.812
GFI1 Pteropus vampyrus ENSPVAG00000006928 I 0.812
GFI1 Taeniopygia guttata ENSTGUG00000006060 I 0.812
Afo_R006147 Aptenodytes forsteri Afo_R006147 I 0.812
GFI1 Bos taurus ENSBTAG00000016723 I 0.812
GFI1 Tursiops truncatus ENSTTRG00000000082 I 0.812
Aan_R000889 Calypte anna Aan_R000889 I 0.812
GFI1 Equus caballus ENSECAG00000006647 I 0.812
Alligator_sinensis_CCG007476.1 Alligator sinensis Alligator_sinensis_CCG007476.1 I 0.812
Gfo_R010648 Geospiza fortis Gfo_R010648 I 0.812
Brh_R002465 Buceros rhinoceros Brh_R002465 I 0.812
ENSPFOG00000023214 Poecilia formosa ENSPFOG00000023214 I 0.810
ENSLOCG00000004711 Lepisosteus oculatus ENSLOCG00000004711 I 0.810
GFI1 Cavia porcellus ENSCPOG00000011727 I 0.810
gfi1ab Danio rerio ENSDARG00000044457 I 0.810
ENSGMOG00000007737 Gadus morhua ENSGMOG00000007737 I 0.810
Cmyd_10004881 Chelonia mydas Cmyd_10004881 I 0.809
ENSPSIG00000008734 Pelodiscus sinensis ENSPSIG00000008734 I 0.809
Pvit_00259 Pogona vitticeps Pvit_00259 I 0.808
gfi1ab Takifugu rubripes ENSTRUG00000000415 I 0.804
gfi1aa Danio rerio ENSDARG00000020746 I 0.804
gfi1ab Tetraodon nigroviridis ENSTNIG00000000651 I 0.802
ENSAMXG00000004835 Astyanax mexicanus ENSAMXG00000004835 I 0.800
gfi1ab Gasterosteus aculeatus ENSGACG00000004257 I 0.794
gfi1aa Gasterosteus aculeatus ENSGACG00000015674 I 0.794
ENSGMOG00000017295 Gadus morhua ENSGMOG00000017295 I 0.787
ENSONIG00000010573 Oreochromis niloticus ENSONIG00000010573 I 0.787
ENSXMAG00000009274 Xiphophorus maculatus ENSXMAG00000009274 I 0.787
ENSPFOG00000017327 Poecilia formosa ENSPFOG00000017327 I 0.787
gfi1aa Oryzias latipes ENSORLG00000005060 I 0.787
gfi1aa Takifugu rubripes ENSTRUG00000004744 I 0.787
SPU_012645 Strongylocentrotus purpuratus SPU_012645 I 0.784
Cmyd_10017172 Chelonia mydas Cmyd_10017172 I 0.784
ENSAPLG00000003373 Anas platyrhynchos ENSAPLG00000003373 I 0.782
GFI1B Meleagris gallopavo ENSMGAG00000006129 I 0.782
Gfo_R007994 Geospiza fortis Gfo_R007994 I 0.782
GFI1B Gallus gallus ENSGALG00000003478 I 0.782
Aan_R008865 Calypte anna Aan_R008865 I 0.782
Tal_R001363 Tyto alba Tal_R001363 I 0.782
Afo_R001655 Aptenodytes forsteri Afo_R001655 I 0.782
ENSFALG00000001479 Ficedula albicollis ENSFALG00000001479 I 0.782
ENSSTOG00000022285 Ictidomys tridecemlineatus ENSSTOG00000022285 I 0.780
ENSPSIG00000012112 Pelodiscus sinensis ENSPSIG00000012112 I 0.780
e_gw.11.853.1 Branchiostoma floridae e_gw.11.853.1 I 0.780
gfi1b Gasterosteus aculeatus ENSGACG00000018134 I 0.780
ENSLACG00000012207 Latimeria chalumnae ENSLACG00000012207 I 0.779
GFI1B Monodelphis domestica ENSMODG00000012600 I 0.779
ENSGMOG00000019123 Gadus morhua ENSGMOG00000019123 I 0.778
GFI1B Cavia porcellus ENSCPOG00000026928 I 0.778
ENSPFOG00000003460 Poecilia formosa ENSPFOG00000003460 I 0.778
ENSLOCG00000005750 Lepisosteus oculatus ENSLOCG00000005750 I 0.778
gfi1b Danio rerio ENSDARG00000079947 I 0.778
Myotis_brandtii_GFI1B_10010118 Myotis brandtii Myotis_brandtii_GFI1B_10010118 I 0.777
ENSP00000361195 Macaca fascicularis ENSP00000361195 I 0.777
ENSPPYG00000019718 Pongo abelii ENSPPYG00000019718 I 0.777
GFI1B Canis familiaris ENSCAFG00000019877 I 0.777
GFI1B Callithrix jacchus ENSCJAG00000018071 I 0.777
ENSMPUG00000012489 Mustela putorius furo ENSMPUG00000012489 I 0.777
Gfi1b Mus musculus ENSMUSG00000026815 D 0.777
ENSNLEG00000012963 Nomascus leucogenys ENSNLEG00000012963 I 0.777
GFI1B Gorilla gorilla ENSGGOG00000015828 I 0.777
GFI1B Homo sapiens ENSG00000165702 D 0.777
Gfi1b Dipodomys ordii ENSDORG00000000342 I 0.777
GFI1B Dasypus novemcinctus ENSDNOG00000036528 I 0.777
GFI1B Equus caballus ENSECAG00000008127 I 0.777
ENSCSAG00000015008 Chlorocebus sabaeus ENSCSAG00000015008 I 0.777
GFI1B Felis catus ENSFCAG00000027147 I 0.777
GFI1B Sus scrofa ENSSSCG00000005737 I 0.777
GFI1B Oryctolagus cuniculus ENSOCUG00000001793 I 0.777
GFI1B Procavia capensis ENSPCAG00000012329 I 0.777
GFI1B Otolemur garnettii ENSOGAG00000008879 I 0.777
GFI1B Pan troglodytes ENSPTRG00000021505 I 0.777
ENSPANG00000024216 Papio anubis ENSPANG00000024216 I 0.777
Gfi1b Rattus norvegicus ENSRNOG00000011353 I 0.777
GFI1B Loxodonta africana ENSLAFG00000022367 I 0.773
CGI_10011355 Crassostrea gigas CGI_10011355 I 0.771
sens-2 Drosophila melanogaster FBgn0051632 D 0.770
GG10437 Drosophila erecta FBgn0102746 I 0.770
MDOA011065 Musca domestica MDOA011065 I 0.770
gfi1b Takifugu rubripes ENSTRUG00000004525 I 0.770
GA16348 Drosophila pseudoobscura FBgn0076363 I 0.770
gfi1b Tetraodon nigroviridis ENSTNIG00000003834 I 0.770
ENSONIG00000013011 Oreochromis niloticus ENSONIG00000013011 I 0.770
GM16223 Drosophila sechellia FBgn0171139 I 0.770
GJ21268 Drosophila virilis FBgn0208401 I 0.770
GK24242 Drosophila willistoni FBgn0226203 I 0.770
GE14143 Drosophila yakuba FBgn0231766 I 0.770
GL26188 Drosophila persimilis FBgn0163770 I 0.770
GI23984 Drosophila mojavensis FBgn0146708 I 0.770
GH13715 Drosophila grimshawi FBgn0121191 I 0.770
tetur16g01570 Tetranychus urticae tetur16g01570 I 0.770
GF15430 Drosophila ananassae FBgn0092455 I 0.770
GFI1B Ornithorhynchus anatinus ENSOANG00000014723 I 0.770
gfi1b Oryzias latipes ENSORLG00000014390 I 0.768
LotgiG129344 Lottia gigantea LotgiG129344 I 0.768
Sakowv30015313m.g Saccoglossus kowalevskii Sakowv30015313m.g I 0.767
GFI1B Bos taurus ENSBTAG00000012772 I 0.767
ENSBTAP00000016974-D1 Bos grunniens ENSBTAP00000016974-D1 I 0.767
GFI1B Macaca mulatta ENSMMUG00000005948 I 0.767
Sakowv30015302m.g Saccoglossus kowalevskii Sakowv30015302m.g I 0.765
NEMVEDRAFT_v1g182742 Nematostella vectensis NEMVEDRAFT_v1g182742 I 0.764
GFI1B Myotis lucifugus ENSMLUG00000006673 I 0.764
LotgiG83709 Lottia gigantea LotgiG83709 I 0.763
gfi1b.L Xenopus laevis XB-GENE-944429 I 0.762
gfi1b Xenopus tropicalis XB-GENE-944426 I 0.762
CGI_10017941 Crassostrea gigas CGI_10017941 I 0.761
CapteG45287 Capitella teleta CapteG45287 I 0.758