SRY (Homo sapiens)
Sox

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00505 (HMG_box) IPR000910 ENSG00000184895 T144114_1.02 Ensembl (2011-Oct-26) Link out
NCBI Gene Info:
This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID DBD
Identity
SRY
M1911_1.02
Homo sapiens
NDWAACAAW

WTTGTWWHN
SELEX
Mathelier et al.(2014)
MA0084.1
(Direct)
SRY
M3961_1.02
Homo sapiens
AAWSWMM

KKWSWTT
Transfac
Matys et al.(2006)
V$SRY_01
(Direct)
SRY
M3962_1.02
Homo sapiens
NHWAACAAWDVD

HBHWTTGTTWDN
Transfac
Matys et al.(2006)
V$SRY_02
(Direct)
SRY
M3963_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SRY_Q6
(Direct)
SRY
M5869_1.02
Homo sapiens
AACAATANCATTGTT

AACAATGNTATTGTT
SELEX
Jolma et al.(2013)
SRY_1
(Direct)
SRY
M5870_1.02
Homo sapiens
AACAATHHNCATTGTT

AACAATGNDDATTGTT
SELEX
Jolma et al.(2013)
SRY_2
(Direct)
SRY
M5871_1.02
Homo sapiens
TCAATAMCATTGA

TCAATGKTATTGA
SELEX
Jolma et al.(2013)
SRY_3
(Direct)
SRY
M5872_1.02
Homo sapiens
TGAATANCATTCA

TGAATGNTATTCA
SELEX
Jolma et al.(2013)
SRY_4
(Direct)
SRY
M6490_1.02
Homo sapiens
DWAACAAWV

BWTTGTTWH
HocoMoco
Kulakovskiy et al.(2013)
SRY_f1
(Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID DBD
Identity
For this family, TFs with SR scores > 0.925 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000372547 Sox 60 128

Links

Other Sox family TFs
Other Homo sapiens TFs

0 Related TFs

">No related TF found