augustus_masked-nMf.1.1.scaf00461-processed-gene-0.2 (Meloidogyne floridensis)

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00096 (zf-C2H2) IPR007087 augustus_masked-nMf.1.1.scaf00461-processed-gene-0.2 T152344_2.00 WormBase:ParaSite (2015-Oct-22)
NCBI Gene Info:
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasng blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Aug 2017]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
augustus_masked-nMf.1.1.scaf00461-processed-gene-0.2-mRNA-1 C2H2 ZF 2 17
augustus_masked-nMf.1.1.scaf00461-processed-gene-0.2-mRNA-1 C2H2 ZF 23 45


Other C2H2 ZF family TFs
Other Meloidogyne floridensis TFs

5 Related TFs

Name Species Gene ID Motif Evidence SR
GF16755 Drosophila ananassae FBgn0093776 N 0.758
ACOM035432 Anopheles coluzzii ACOM035432 N 0.758
genemark-nMf.1.1.scaf33746-processed-gene-0.0 Meloidogyne floridensis genemark-nMf.1.1.scaf33746-processed-gene-0.0 N 0.818
nRc.2.0.1.g36729 Romanomermis culicivorax nRc.2.0.1.g36729 N 0.757
nRc.2.0.1.g45858 Romanomermis culicivorax nRc.2.0.1.g45858 N 0.763