MYT1L (Homo sapiens)
C2HC ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF01530 (zf-C2HC) IPR002515 ENSG00000186487 T159009_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. Mutations in this gene have been associated with an autosomal dominant form of cognitive disability and with autism spectrum disorder. Alternative splicing results in multiple variants. [provided by RefSeq, Jul 2017]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ztf-11
M00650_2.00 		Caenorhabditis elegans
VAAGTTTN
NAAACTTB		 PBM
Narasimhan et al.(2015)
pTH9925 		0.789 0.789
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000382111 C2HC ZF 7 35
ENSP00000382111 C2HC ZF 60 88
ENSP00000382114 C2HC ZF 30 58
ENSP00000382114 C2HC ZF 505 532
ENSP00000382114 C2HC ZF 549 577
ENSP00000382114 C2HC ZF 904 932
ENSP00000382114 C2HC ZF 953 981
ENSP00000382114 C2HC ZF 1006 1034
ENSP00000384219 C2HC ZF 2 30
ENSP00000396103 C2HC ZF 30 58
ENSP00000396103 C2HC ZF 503 530
ENSP00000396103 C2HC ZF 547 575
ENSP00000396103 C2HC ZF 902 930
ENSP00000396103 C2HC ZF 951 979
ENSP00000396103 C2HC ZF 1004 1032
ENSP00000473409 C2HC ZF 159 186
ENSP00000473409 C2HC ZF 203 231

Links

Other C2HC ZF family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

331 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action