CENPB (Homo sapiens)
CENPB

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF04218 (CENP-B_N) IPR006695 ENSG00000125817 T161466_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
CENPB
M02939_2.00		 Homo sapiens
CCCGYDTNNNRCGWA
TWCGYNNNAHRCGGG		 SELEX
Jolma et al.(2013)
CENPB_1		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000369075 CENPB 2 56

Links

Other CENPB family TFs
Other Homo sapiens TFs

15 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
CENPB Otolemur garnettii ENSOGAG00000034679 I 1.000
ENSPANG00000018561 Papio anubis ENSPANG00000018561 I 1.000
CENPB Pan troglodytes ENSPTRG00000028950 I 1.000
Cenpb Rattus norvegicus ENSRNOG00000057284 I 1.000
ENSSTOG00000024375 Ictidomys tridecemlineatus ENSSTOG00000024375 I 1.000
CENPB Tursiops truncatus ENSTTRG00000009462 I 1.000
Cenpb Dipodomys ordii ENSDORG00000003851 I 1.000
ENSCSAG00000018760 Chlorocebus sabaeus ENSCSAG00000018760 I 1.000
Cenpb Mus musculus ENSMUSG00000068267 I 1.000
CENPB Procavia capensis ENSPCAG00000008643 I 0.981
ENSBTAG00000045784 Bos taurus ENSBTAG00000045784 I 0.979
ENSNLEG00000018556 Nomascus leucogenys ENSNLEG00000018556 I 0.974
CENPB Monodelphis domestica ENSMODG00000015345 I 0.962
CENPB Ornithorhynchus anatinus ENSOANG00000002467 I 0.943
ENSOARG00000004723 Ovis aries ENSOARG00000004723 I 0.938