LIN28A (Homo sapiens)
CSD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00313 (CSD) IPR002059 ENSG00000131914 T164568_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
LIN28B
M04663_2.00 		Homo sapiens
CGCGRWRDRRCDGCG
CGCHGYYHYWYCGCG		 SELEX
Yin et al.(2017)
LIN28B_FL_HT-SELEX 		0.864 0.864
LIN28B
M04664_2.00 		Homo sapiens
CGCGRTRNNRCDGCG
CGCHGYNNYAYCGCG		 SELEX
Yin et al.(2017)
LIN28B_FL_Methyl-HT-SELEX 		0.864 0.864
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000254231 CSD 40 112
ENSP00000363314 CSD 40 112

Links

Other CSD family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

153 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action