Su(H) (Drosophila melanogaster)
CSL

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF09271 (LAG1-DNAbind) IPR015351 FBgn0004837 T166147_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone acetyltransferase binding activity. Contributes to DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including imaginal disc development; long-term memory; and regulation of transcription by RNA polymerase II. Located in cytoplasm; nucleus; and polytene chromosome. Part of CSL-Notch-Mastermind transcription factor complex and RNA polymerase II transcription repressor complex. Is expressed in several structures, including cuboidal/columnar epithelium; ectoderm anlage; extended germ band embryo; larval imaginal tissue; and proneural cluster. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Orthologous to human RBPJ (recombination signal binding protein for immunoglobulin kappa J region). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Su(H)
M08455_2.00		 Drosophila melanogaster
HBHNVGKTTCYCACRV
BYGTGRGAAMCBNDVD		 COMPILED
Mathelier et al.(2014)
MA0085.1		 (Direct) (Direct)
Su(H)
M10415_2.00		 Drosophila melanogaster
VGKTTCYCACRVY
RBYGTGRGAAMCB		 Transfac
Matys et al.(2006)
I$SUH_01		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
RBPJ
M00735_2.00 		Homo sapiens
NNNBTCHCAN
NTGDGAVNNN		 PBM
DelBianco et al.(2010)
GST-CSL_Fig2 		0.794 0.794
RBPJ
M00736_2.00 		Homo sapiens
NNNYTCHCAN
NTGDGARNNN		 PBM
DelBianco et al.(2010)
GST-CSL_Fig4 		0.794 0.794
RBPJ
M00737_2.00 		Homo sapiens
NNNBTCHCAN
NTGDGAVNNN		 PBM
DelBianco et al.(2010)
GST-CSL-NOTCH1 		0.794 0.794
RBPJ
M00738_2.00 		Homo sapiens
NBTCHCAN
NTGDGAVN		 PBM
DelBianco et al.(2010)
GST-NOTCH1_CSL-6His_MAML1 		0.794 0.794
RBPJ
M00739_2.00 		Homo sapiens
NNBTCHCAN
NTGDGAVNN		 PBM
DelBianco et al.(2010)
GST-NOTCH1_CSL-6His 		0.794 0.794
RBPJ
M00740_2.00 		Homo sapiens
NNNYTCYCAN
NTGRGARNNN		 PBM
DelBianco et al.(2010)
GST-NOTCH1_Fig2 		0.794 0.794
RBPJ
M00741_2.00 		Homo sapiens
NNNBTCHCAN
NTGDGAVNNN		 PBM
DelBianco et al.(2010)
MAML1-CSL-GST-NOTCH1_Fig2 		0.794 0.794
RBPJ
M00742_2.00 		Homo sapiens
NDYTCHCAB
VTGDGARHN		 PBM
DelBianco et al.(2010)
MAML1-CSL-GST-NOTCH1_Fig5 		0.794 0.794
RBPJ
M08105_2.00 		Homo sapiens
NNTTCCCABN
NVTGGGAANN		 ChIP-seq
Mathelier et al.(2014)
MA1116.1 		0.794 0.794
RBPJ
M09020_2.00 		Homo sapiens
BTTCCCASVVN
NBBSTGGGAAV		 Misc
Kulakovskiy et al.(2013)
SUH_HUMAN.H11MO.0.A 		0.794 0.794
Rbpj
M09021_2.00 		Mus musculus
NBTTCCCASVV
BBSTGGGAAVN		 Misc
Kulakovskiy et al.(2013)
SUH_MOUSE.H11MO.0.A 		0.794 0.794
RBPJ
M10413_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$RBPJK_01 		0.794 0.794
RBPJ
M10414_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$RBPJK_Q4 		0.794 0.794
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0080261 CSL 122 252
FBpp0312201 CSL 122 252

Links

Other CSL family TFs
Other Drosophila melanogaster TFs

Invalid Input OrderBy

172 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action