ENSP00000354528 (Macaca fascicularis)
CSL

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF09271 (LAG1-DNAbind) IPR015351 ENSP00000354528 T166303_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
RBPJ
M00735_2.00 		Homo sapiens
NNNBTCHCAN
NTGDGAVNNN		 PBM
DelBianco et al.(2010)
GST-CSL_Fig2 		1.000 1.000
RBPJ
M00736_2.00 		Homo sapiens
NNNYTCHCAN
NTGDGARNNN		 PBM
DelBianco et al.(2010)
GST-CSL_Fig4 		1.000 1.000
RBPJ
M00737_2.00 		Homo sapiens
NNNBTCHCAN
NTGDGAVNNN		 PBM
DelBianco et al.(2010)
GST-CSL-NOTCH1 		1.000 1.000
RBPJ
M00738_2.00 		Homo sapiens
NBTCHCAN
NTGDGAVN		 PBM
DelBianco et al.(2010)
GST-NOTCH1_CSL-6His_MAML1 		1.000 1.000
RBPJ
M00739_2.00 		Homo sapiens
NNBTCHCAN
NTGDGAVNN		 PBM
DelBianco et al.(2010)
GST-NOTCH1_CSL-6His 		1.000 1.000
RBPJ
M00740_2.00 		Homo sapiens
NNNYTCYCAN
NTGRGARNNN		 PBM
DelBianco et al.(2010)
GST-NOTCH1_Fig2 		1.000 1.000
RBPJ
M00741_2.00 		Homo sapiens
NNNBTCHCAN
NTGDGAVNNN		 PBM
DelBianco et al.(2010)
MAML1-CSL-GST-NOTCH1_Fig2 		1.000 1.000
RBPJ
M00742_2.00 		Homo sapiens
NDYTCHCAB
VTGDGARHN		 PBM
DelBianco et al.(2010)
MAML1-CSL-GST-NOTCH1_Fig5 		1.000 1.000
RBPJ
M08105_2.00 		Homo sapiens
NNTTCCCABN
NVTGGGAANN		 ChIP-seq
Mathelier et al.(2014)
MA1116.1 		1.000 1.000
RBPJ
M09020_2.00 		Homo sapiens
BTTCCCASVVN
NBBSTGGGAAV		 Misc
Kulakovskiy et al.(2013)
SUH_HUMAN.H11MO.0.A 		1.000 1.000
Rbpj
M09021_2.00 		Mus musculus
NBTTCCCASVV
BBSTGGGAAVN		 Misc
Kulakovskiy et al.(2013)
SUH_MOUSE.H11MO.0.A 		1.000 1.000
RBPJ
M10413_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$RBPJK_01 		1.000 1.000
RBPJ
M10414_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$RBPJK_Q4 		1.000 1.000
Su(H)
M10415_2.00 		Drosophila melanogaster
VGKTTCYCACRVY
RBYGTGRGAAMCB		 Transfac
Matys et al.(2006)
I$SUH_01 		0.794 0.794
Su(H)
M08455_2.00 		Drosophila melanogaster
HBHNVGKTTCYCACRV
BYGTGRGAAMCBNDVD		 COMPILED
Mathelier et al.(2014)
MA0085.1 		0.794 0.794
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000354528 CSL 48 178

Links

Other CSL family TFs
Other Macaca fascicularis TFs

Invalid Input OrderBy

165 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action