CUX2 (Homo sapiens)
CUT,Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02376 (CUT)
PF00046 (Homeobox)
IPR003350
IPR001356
ENSG00000111249 T167057_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding motifs. A similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome on chromosome 7. Two pseudogenes of this gene have been identified on chromosomes 10 and 4. [provided by RefSeq, Jan 2013]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
CUX2
M01499_2.00
Homo sapiens
NKATYRVNN

NNBYRATMN
PBM
Yin et al.(2017b)
CUX2_5mCG
(Direct) (Direct)
CUX2
M01500_2.00
Homo sapiens
NDATYRRHN

NDYYRATHN
PBM
Yin et al.(2017b)
CUX2_Cytosine
(Direct) (Direct)
CUX2
M02940_2.00
Homo sapiens
ATCRATAHNNDWATCGAT

ATCGATWHNNDTATYGAT
SELEX
Jolma et al.(2013)
CUX2_1
(Direct) (Direct)
CUX2
M02941_2.00
Homo sapiens
DDATYGATYA

TRATCRATHH
SELEX
Jolma et al.(2013)
CUX2_2
(Direct) (Direct)
CUX2
M04665_2.00
Homo sapiens
NTRATCGATYRN

NYRATCGATYAN
SELEX
Yin et al.(2017)
CUX2_eDBD_HT-SELEX
(Direct) (Direct)
CUX2
M04666_2.00
Homo sapiens
BYRATCGATYRB

VYRATCGATYRV
SELEX
Yin et al.(2017)
CUX2_eDBD_Methyl-HT-SELEX
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Cux2
M09025_2.00
Mus musculus
NBBATTGATYD

HRATCAATVVN
Misc
Kulakovskiy et al.(2013)
CUX2_MOUSE.H11MO.0.C
0.986 0.986
CUX1
M02946_2.00
Homo sapiens
ATCRATHNNNDATCRAT

ATYGATHNNNDATYGAT
SELEX
Jolma et al.(2013)
CUX1_1
0.888 0.888
CUX1
M02947_2.00
Homo sapiens
ATCRATHNNNNDATCRAT

ATYGATHNNNNDATYGAT
SELEX
Jolma et al.(2013)
CUX1_2
0.888 0.888
CUX1
M02948_2.00
Homo sapiens
TDATCRATNN

NNATYGATHA
SELEX
Jolma et al.(2013)
CUX1_3
0.888 0.888
CUX1
M04679_2.00
Homo sapiens
NDATCRATNN

NNATYGATHN
SELEX
Yin et al.(2017)
CUX1_eDBD_HT-SELEX
0.888 0.888
CUX1
M09023_2.00
Homo sapiens
RBRVNDATYGRTBN

NVAYCRATHNBYVY
Misc
Kulakovskiy et al.(2013)
CUX1_HUMAN.H11MO.0.C
0.888 0.888
Cux1
M09024_2.00
Mus musculus
RBRVNDATYGRTBN

NVAYCRATHNBYVY
Misc
Kulakovskiy et al.(2013)
CUX1_MOUSE.H11MO.0.C
0.888 0.888
CUX1
M10422_2.00
Homo sapiens
CCAATAATCRAT

ATYGATTATTGG
Transfac
Matys et al.(2006)
V$CDP_01
0.888 0.888
CUX1
M10423_2.00
Homo sapiens
DWDATCGATYADHDH

DHDHTRATCGATHWH
Transfac
Matys et al.(2006)
V$CDP_02
0.888 0.888
CUX1
M10424_2.00
Homo sapiens
SCVATCRATN

NATYGATBGS
Transfac
Matys et al.(2006)
V$CDPCR1_01
0.888 0.888
CUX1
M10425_2.00
Homo sapiens
CVATABNTATYKGTG

CACMRATANVTATBG
Transfac
Matys et al.(2006)
V$CDPCR3_01
0.888 0.888
CUX1
M10426_2.00
Homo sapiens
SVSATCRATB

VATYGATSBS
Transfac
Matys et al.(2006)
V$CDPCR3HD_01
0.888 0.888
CUX1
M10427_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CDP_Q6_01
0.888 0.888
CUX1
M10416_2.00
Canis familiaris
DHDATYGATYADYDW

WHRHTRATCRATHDH
Transfac
Matys et al.(2006)
V$CLOX_01
0.888 0.888
CUX1
M04680_2.00
Homo sapiens
NBATTGATHR

YDATCAATVN
SELEX
Yin et al.(2017)
CUX1_eDBD_Methyl-HT-SELEX
0.888 0.888
For this family, TFs with SR scores > 0.700 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M01499_2.00 CUT 25 103
M01499_2.00 CUT 368 443
M01499_2.00 CUT 519 596
M01499_2.00 Homeodomain 645 701
M01500_2.00 CUT 25 103
M01500_2.00 CUT 368 443
M01500_2.00 CUT 519 596
M01500_2.00 Homeodomain 645 701

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000261726 CUT 549 627
ENSP00000261726 CUT 892 967
ENSP00000261726 CUT 1043 1120
ENSP00000261726 Homeodomain 1169 1225

Links

Other CUT,Homeodomain family TFs
Other Homo sapiens TFs

111 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action