ct (Drosophila melanogaster)
CUT,Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02376 (CUT)
PF00046 (Homeobox) 		IPR003350
IPR001356 		FBgn0004198 T167324_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables transcription cis-regulatory region binding activity. Involved in several processes, including Malpighian tubule bud morphogenesis; formation of a compartment boundary; and imaginal disc-derived appendage morphogenesis. Located in nucleus. Is expressed in several structures, including anterior-posterior subdivision of organism; epithelium; extended germ band embryo; mechanosensory sensory organ; and nervous system. Used to study cancer and hematologic cancer. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 67. Orthologous to several human genes including CUX2 (cut like homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ct
M06471_2.00		 Drosophila melanogaster
YTRAAC
GTTYAR		 B1H
Mathelier et al.(2014)
MA0218.1		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0071026 CUT 882 959
FBpp0071026 CUT 1335 1414
FBpp0071026 CUT 1614 1692
FBpp0071026 Homeodomain 1746 1802
FBpp0113105 CUT 1090 1167
FBpp0113105 CUT 1543 1622
FBpp0113105 CUT 1822 1900
FBpp0113105 Homeodomain 1954 2010
FBpp0293664 CUT 872 949
FBpp0293664 CUT 1325 1404
FBpp0293664 CUT 1604 1682
FBpp0293664 Homeodomain 1736 1792
FBpp0304122 CUT 881 958
FBpp0304122 CUT 1334 1413
FBpp0304122 CUT 1613 1691
FBpp0304122 Homeodomain 1745 1801

Links

Other CUT,Homeodomain family TFs
Other Drosophila melanogaster TFs

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52 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action