MBD1 (Homo sapiens)
CxxC,MBD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02008 (zf-CXXC)
PF01429 (MBD)
IPR002857
IPR001739
ENSG00000141644 T167665_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000269468 MBD 1 88
ENSP00000269468 CxxC 168 215
ENSP00000269468 CxxC 217 262
ENSP00000269468 CxxC 330 377
ENSP00000269469 MBD 1 88
ENSP00000269469 CxxC 168 213
ENSP00000269469 CxxC 281 328
ENSP00000269471 MBD 1 88
ENSP00000269471 CxxC 168 215
ENSP00000269471 CxxC 217 262
ENSP00000269471 CxxC 307 354
ENSP00000285102 MBD 1 88
ENSP00000285102 CxxC 168 215
ENSP00000285102 CxxC 217 262
ENSP00000339546 MBD 1 88
ENSP00000339546 CxxC 168 215
ENSP00000339546 CxxC 217 262
ENSP00000339546 CxxC 330 377
ENSP00000372407 MBD 1 88
ENSP00000372407 CxxC 168 215
ENSP00000372407 CxxC 217 262
ENSP00000372407 CxxC 330 377
ENSP00000381502 MBD 1 89
ENSP00000381502 CxxC 168 215
ENSP00000381502 CxxC 217 262
ENSP00000381506 MBD 1 88
ENSP00000381506 CxxC 168 215
ENSP00000381506 CxxC 217 262
ENSP00000381508 MBD 1 88
ENSP00000381508 CxxC 168 215
ENSP00000381508 CxxC 217 262
ENSP00000405268 MBD 1 88
ENSP00000405268 CxxC 168 215
ENSP00000405268 CxxC 217 262
ENSP00000405268 CxxC 355 402
ENSP00000464823 MBD 1 41
ENSP00000465923 MBD 1 88
ENSP00000465923 CxxC 168 215
ENSP00000465923 CxxC 217 262
ENSP00000465923 CxxC 307 354
ENSP00000466092 MBD 1 88
ENSP00000466092 CxxC 168 213
ENSP00000466092 CxxC 280 327
ENSP00000466429 CxxC 36 83
ENSP00000466429 CxxC 85 130
ENSP00000467017 MBD 1 88
ENSP00000467017 CxxC 168 215
ENSP00000467017 CxxC 217 262
ENSP00000467017 CxxC 330 377
ENSP00000467606 CxxC 93 138
ENSP00000467763 MBD 1 88
ENSP00000467763 CxxC 168 215
ENSP00000467763 CxxC 217 262
ENSP00000467763 CxxC 307 354
ENSP00000468042 MBD 1 88
ENSP00000468042 CxxC 168 215
ENSP00000468042 CxxC 217 262
ENSP00000468430 MBD 1 88
ENSP00000468430 CxxC 168 215
ENSP00000468430 CxxC 217 262
ENSP00000468430 CxxC 355 402
ENSP00000468785 MBD 1 88
ENSP00000468785 CxxC 168 215
ENSP00000468785 CxxC 217 262
ENSP00000468785 CxxC 330 377

Links

Other CxxC,MBD family TFs
Other Homo sapiens TFs

35 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
MBD1 Gorilla gorilla ENSGGOG00000016966 N 1.000
MBD1 Pan troglodytes ENSPTRG00000010021 N 1.000
MBD1 Tupaia belangeri ENSTBEG00000012651 N 1.000
MBD1 Macaca mulatta ENSMMUG00000009050 N 0.995
ENSPANG00000010867 Papio anubis ENSPANG00000010867 N 0.995
ENSPPYG00000009158 Pongo abelii ENSPPYG00000009158 N 0.995
ENSMMUP00000011865 Macaca fascicularis ENSMMUP00000011865 N 0.995
ENSNLEG00000011661 Nomascus leucogenys ENSNLEG00000011661 N 0.995
ENSCSAG00000018070 Chlorocebus sabaeus ENSCSAG00000018070 N 0.995
MBD1 Callithrix jacchus ENSCJAG00000004959 N 0.991
MBD1 Otolemur garnettii ENSOGAG00000003784 N 0.986
ENSTSYG00000000509 Tarsius syrichta ENSTSYG00000000509 N 0.982
MBD1 Tursiops truncatus ENSTTRG00000015523 N 0.967
MBD1 Canis familiaris ENSCAFG00000018928 N 0.967
MBD1 Felis catus ENSFCAG00000015730 N 0.967
ENSSTOG00000007780 Ictidomys tridecemlineatus ENSSTOG00000007780 N 0.962
ENSMPUG00000008843 Mustela putorius furo ENSMPUG00000008843 N 0.962
ENSAMEG00000000238 Ailuropoda melanoleuca ENSAMEG00000000238 N 0.962
MBD1 Sus scrofa ENSSSCG00000004516 N 0.958
MBD1 Dasypus novemcinctus ENSDNOG00000015998 N 0.958
MBD1 Equus caballus ENSECAG00000011497 N 0.958
MBD1 Bos taurus ENSBTAG00000003801 N 0.958
ENSOARG00000004218 Ovis aries ENSOARG00000004218 N 0.958
MBD1 Cavia porcellus ENSCPOG00000001671 N 0.944
Myotis_brandtii_MBD1_10005913 Myotis brandtii Myotis_brandtii_MBD1_10005913 N 0.939
MBD1 Myotis lucifugus ENSMLUG00000008286 N 0.939
MBD1 Ochotona princeps ENSOPRG00000007647 N 0.939
MBD1 Procavia capensis ENSPCAG00000001648 N 0.934
ENSBTAP00000004954-D1 Bos grunniens ENSBTAP00000004954-D1 N 0.930
MBD1 Oryctolagus cuniculus ENSOCUG00000006554 N 0.925
MBD1 Loxodonta africana ENSLAFG00000031328 N 0.911
Mbd1 Dipodomys ordii ENSDORG00000013917 N 0.887
Mbd1 Mus musculus ENSMUSG00000024561 N 0.848
MBD1 Ornithorhynchus anatinus ENSOANG00000014593 N 0.722