MBD1 (Homo sapiens)
CxxC,MBD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02008 (zf-CXXC)
PF01429 (MBD) 		IPR002857
IPR001739 		ENSG00000141644 T167665_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000269468 MBD 1 88
ENSP00000269468 CxxC 168 215
ENSP00000269468 CxxC 217 262
ENSP00000269468 CxxC 330 377
ENSP00000269469 MBD 1 88
ENSP00000269469 CxxC 168 213
ENSP00000269469 CxxC 281 328
ENSP00000269471 MBD 1 88
ENSP00000269471 CxxC 168 215
ENSP00000269471 CxxC 217 262
ENSP00000269471 CxxC 307 354
ENSP00000285102 MBD 1 88
ENSP00000285102 CxxC 168 215
ENSP00000285102 CxxC 217 262
ENSP00000339546 MBD 1 88
ENSP00000339546 CxxC 168 215
ENSP00000339546 CxxC 217 262
ENSP00000339546 CxxC 330 377
ENSP00000372407 MBD 1 88
ENSP00000372407 CxxC 168 215
ENSP00000372407 CxxC 217 262
ENSP00000372407 CxxC 330 377
ENSP00000381502 MBD 1 89
ENSP00000381502 CxxC 168 215
ENSP00000381502 CxxC 217 262
ENSP00000381506 MBD 1 88
ENSP00000381506 CxxC 168 215
ENSP00000381506 CxxC 217 262
ENSP00000381508 MBD 1 88
ENSP00000381508 CxxC 168 215
ENSP00000381508 CxxC 217 262
ENSP00000405268 MBD 1 88
ENSP00000405268 CxxC 168 215
ENSP00000405268 CxxC 217 262
ENSP00000405268 CxxC 355 402
ENSP00000464823 MBD 1 41
ENSP00000465923 MBD 1 88
ENSP00000465923 CxxC 168 215
ENSP00000465923 CxxC 217 262
ENSP00000465923 CxxC 307 354
ENSP00000466092 MBD 1 88
ENSP00000466092 CxxC 168 213
ENSP00000466092 CxxC 280 327
ENSP00000466429 CxxC 36 83
ENSP00000466429 CxxC 85 130
ENSP00000467017 MBD 1 88
ENSP00000467017 CxxC 168 215
ENSP00000467017 CxxC 217 262
ENSP00000467017 CxxC 330 377
ENSP00000467606 CxxC 93 138
ENSP00000467763 MBD 1 88
ENSP00000467763 CxxC 168 215
ENSP00000467763 CxxC 217 262
ENSP00000467763 CxxC 307 354
ENSP00000468042 MBD 1 88
ENSP00000468042 CxxC 168 215
ENSP00000468042 CxxC 217 262
ENSP00000468430 MBD 1 88
ENSP00000468430 CxxC 168 215
ENSP00000468430 CxxC 217 262
ENSP00000468430 CxxC 355 402
ENSP00000468785 MBD 1 88
ENSP00000468785 CxxC 168 215
ENSP00000468785 CxxC 217 262
ENSP00000468785 CxxC 330 377

Links

Other CxxC,MBD family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

35 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action