| NCBI Gene Info:Enables DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates. Involved in DNA methylation and negative regulation of gene expression. Acts upstream of or within several processes, including Kupffer's vesicle development; animal organ development; and macromolecule methylation. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; immature eye; nervous system; neural tube; and tail bud. Human ortholog(s) of this gene implicated in Graves' disease; autosomal dominant cerebellar ataxia, deafness and narcolepsy; hereditary sensory neuropathy; hereditary sensory neuropathy type 1E; and lung non-small cell carcinoma. Orthologous to human DNMT1 (DNA methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022] |