kdm2aa (Danio rerio)
CxxC

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02008 (zf-CXXC) IPR002857 ENSDARG00000059653 T167916_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable histone demethylase activity and transcription coregulator activity. Acts upstream of or within sex determination. Predicted to be located in nucleus. Used to study melanoma. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human KDM2A (lysine demethylase 2A). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
kdm2aa
M01910_2.00		 Danio rerio
NCGNNNNNN
NNNNNNCGN		 PBM
Weirauch et al.(2014)
pTH8585		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
KDM2B
M01911_2.00 		Homo sapiens
NNNNNNCGN
NCGNNNNNN		 PBM
Weirauch et al.(2014)
pTH9191 		0.723 0.723
FBXL19
M01916_2.00 		Tetraodon nigroviridis
NNNNCGNN
NNCGNNNN		 PBM
Weirauch et al.(2014)
pTH8570 		0.723 0.723
A6H8I1_DANRE
M01906_2.00 		Danio rerio
CGTACGYA
TRCGTACG		 PBM
Weirauch et al.(2014)
pTH9257 		0.702 0.702
kdm2ba
M01909_2.00 		Danio rerio
NNNNCGN
NCGNNNN		 PBM
Weirauch et al.(2014)
pTH8577 		0.702 0.702
For this family, TFs with SR scores > 0.700 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M01910_2.00 CxxC 51 97

DNA Binding Domains

Protein ID Domain From To Sequence
ENSDARP00000116460 CxxC 167 213
ENSDARP00000121246 CxxC 499 545
ENSDARP00000134050 CxxC 499 545

Links

Other CxxC family TFs
Other Danio rerio TFs

Invalid Input OrderBy

205 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action