CXXC1 (Homo sapiens)
CxxC

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02008 (zf-CXXC) IPR002857 ENSG00000154832 T167985_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and is essential for vertebrate development. [provided by RefSeq, Sep 2015]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
CXXC1
M10428_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CGBP_01
(Direct) (Direct)
CXXC1
M10429_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CGBP_02
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
BAD93120.1_CONSTRUCT
M01919_2.00
PBM CONSTRUCTS
NNNBCGN

NCGVNNN
PBM
Weirauch et al.(2014)
pTH7032
1.000 1.000
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000285106 CxxC 160 208
ENSP00000390475 CxxC 160 208
ENSP00000465284 CxxC 160 208
ENSP00000465849 CxxC 8 56
ENSP00000467634 CxxC 160 208
ENSP00000468038 CxxC 160 208

Links

Other CxxC family TFs
Other Homo sapiens TFs

80 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Alligator_sinensis_CCG018976.1 Alligator sinensis Alligator_sinensis_CCG018976.1 I 0.979
BAD93120.1_CONSTRUCT PBM CONSTRUCTS BAD93120.1_CONSTRUCT D 1.000
CapteG177878 Capitella teleta CapteG177878 I 0.708
CGI_10003574 Crassostrea gigas CGI_10003574 I 0.771
Cmyd_10001830 Chelonia mydas Cmyd_10001830 I 0.979
CXXC1 Monodelphis domestica ENSMODG00000010555 I 1.000
Cxxc1 Rattus norvegicus ENSRNOG00000014614 I 1.000
CXXC1 Pteropus vampyrus ENSPVAG00000015608 I 1.000
CXXC1 Gorilla gorilla ENSGGOG00000016976 I 0.854
CXXC1 Pan troglodytes ENSPTRG00000010022 I 1.000
CXXC1 Otolemur garnettii ENSOGAG00000033715 I 0.979
CXXC1 Oryctolagus cuniculus ENSOCUG00000025756 I 1.000
CXXC1 Microcebus murinus ENSMICG00000006424 I 1.000
CXXC1 Myotis lucifugus ENSMLUG00000025328 I 1.000
CXXC1 Ornithorhynchus anatinus ENSOANG00000014594 I 1.000
CXXC1 Macaca mulatta ENSMMUG00000009051 I 1.000
CXXC1 Felis catus ENSFCAG00000006135 I 1.000
CXXC1 Equus caballus ENSECAG00000017698 I 1.000
CXXC1 Anolis carolinensis ENSACAG00000006087 I 0.979
cxxc1 Xenopus tropicalis XB-GENE-5910691 I 0.958
CXXC1 Bos taurus ENSBTAG00000021884 I 1.000
CXXC1 Canis familiaris ENSCAFG00000018892 I 1.000
CXXC1 Ochotona princeps ENSOPRG00000013787 I 1.000
CXXC1 Cavia porcellus ENSCPOG00000020250 I 1.000
CXXC1 Tursiops truncatus ENSTTRG00000015535 I 1.000
CXXC1 Sus scrofa ENSSSCG00000004517 I 1.000
CXXC1 Dasypus novemcinctus ENSDNOG00000032991 I 1.000
Cxxc1 Mus musculus ENSMUSG00000024560 I 1.000
cxxc1.S Xenopus laevis XB-GENE-5910788 I 0.917
cxxc1a Gasterosteus aculeatus ENSGACG00000001153 I 0.729
cxxc1a Takifugu rubripes ENSTRUG00000005220 I 0.750
cxxc1a Tetraodon nigroviridis ENSTNIG00000001822 I 0.750
cxxc1a Danio rerio ENSDARG00000101996 I 0.771
cxxc1b Gasterosteus aculeatus ENSGACG00000012117 I 0.792
cxxc1b Danio rerio ENSDARG00000025718 I 0.875
cxxc1b Takifugu rubripes ENSTRUG00000013293 I 0.833
cxxc1b Oryzias latipes ENSORLG00000014161 I 0.833
cxxc1b Tetraodon nigroviridis ENSTNIG00000007325 I 0.812
ENSAMEG00000000259 Ailuropoda melanoleuca ENSAMEG00000000259 I 1.000
ENSAMXG00000006383 Astyanax mexicanus ENSAMXG00000006383 I 0.854
ENSAMXG00000016944 Astyanax mexicanus ENSAMXG00000016944 I 0.875
ENSAPLG00000005571 Anas platyrhynchos ENSAPLG00000005571 I 0.812
ENSCJAG00000005044 Callithrix jacchus ENSCJAG00000005044 I 1.000
ENSCJAG00000005472 Callithrix jacchus ENSCJAG00000005472 I 0.938
ENSCSAG00000018072 Chlorocebus sabaeus ENSCSAG00000018072 I 1.000
ENSGMOG00000002734 Gadus morhua ENSGMOG00000002734 I 0.750
ENSLACG00000001387 Latimeria chalumnae ENSLACG00000001387 I 0.896
ENSLOCG00000014684 Lepisosteus oculatus ENSLOCG00000014684 I 0.750
ENSMEUG00000001457 Macropus eugenii ENSMEUG00000001457 I 1.000
ENSMPUG00000008831 Mustela putorius furo ENSMPUG00000008831 I 1.000
ENSNLEG00000011746 Nomascus leucogenys ENSNLEG00000011746 I 1.000
ENSOARG00000004310 Ovis aries ENSOARG00000004310 I 0.979
ENSONIG00000000828 Oreochromis niloticus ENSONIG00000000828 I 0.750
ENSONIG00000020290 Oreochromis niloticus ENSONIG00000020290 I 0.833
ENSORLG00000019591 Oryzias latipes ENSORLG00000019591 I 0.750
ENSP00000390475 Macaca fascicularis ENSP00000390475 I 1.000
ENSP00000390475-D1 Bos grunniens ENSP00000390475-D1 I 1.000
ENSPANG00000009435 Papio anubis ENSPANG00000009435 I 1.000
ENSPFOG00000001601 Poecilia formosa ENSPFOG00000001601 I 0.750
ENSPFOG00000007618 Poecilia formosa ENSPFOG00000007618 I 0.812
ENSPSIG00000008595 Pelodiscus sinensis ENSPSIG00000008595 I 0.979
ENSSARG00000002011 Sorex araneus ENSSARG00000002011 I 1.000
ENSSHAG00000003967 Sarcophilus harrisii ENSSHAG00000003967 I 1.000
ENSSTOG00000029092 Ictidomys tridecemlineatus ENSSTOG00000029092 I 1.000
ENSXMAG00000005630 Xiphophorus maculatus ENSXMAG00000005630 I 0.812
ENSXMAG00000013043 Xiphophorus maculatus ENSXMAG00000013043 I 0.750
estExt_fgenesh2_pg.C_1650060 Branchiostoma floridae estExt_fgenesh2_pg.C_1650060 I 0.854
estExt_fgenesh2_pg.C_1650087 Branchiostoma floridae estExt_fgenesh2_pg.C_1650087 I 0.854
FQ377654.1 Danio rerio ENSDARG00000098299 I 0.707
HelroG112476 Helobdella robusta HelroG112476 I 0.708
LotgiG223348 Lottia gigantea LotgiG223348 I 0.708
Myotis_brandtii_CXXC1_10005914 Myotis brandtii Myotis_brandtii_CXXC1_10005914 I 0.771
Ocbimv22022574m.g Octopus bimaculoides Ocbimv22022574m.g I 0.771
Ogr11309 Ophisaurus gracilis Ogr11309 I 0.958
Pvit_00275 Pogona vitticeps Pvit_00275 I 0.833
Sakowv30043410m.g Saccoglossus kowalevskii Sakowv30043410m.g I 0.750
SMAR003348 Strigamia maritima SMAR003348 I 0.750
SPU_002500 Strongylocentrotus purpuratus SPU_002500 I 0.708
XP_002943289 Xenopus tropicalis XP_002943289 I 0.958