KDM2A (Homo sapiens)

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02008 (zf-CXXC) IPR002857 ENSG00000173120 T167988_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Meleagris gallopavo

Weirauch et al.(2014)
0.936 0.936
Danio rerio

Weirauch et al.(2014)
0.809 0.809
Homo sapiens

Weirauch et al.(2014)
0.787 0.787
Tetraodon nigroviridis

Weirauch et al.(2014)
0.787 0.787
Danio rerio

Weirauch et al.(2014)
0.745 0.745
Danio rerio

Weirauch et al.(2014)
0.702 0.702
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000309302 CxxC 546 592
ENSP00000381640 CxxC 563 609
ENSP00000432786 CxxC 563 609
ENSP00000435776 CxxC 124 170


Other CxxC family TFs
Other Homo sapiens TFs

204 Related TFs

Name Species Gene ID Motif Evidence SR
A6H8I1_DANRE Danio rerio A6H8I1_DANRE D 0.745
kdm2ba Danio rerio ENSDARG00000036593 D 0.809
kdm2aa Danio rerio ENSDARG00000059653 D 0.702
KDM2A Meleagris gallopavo ENSMGAG00000010309 D 0.936
FBXL19 Tetraodon nigroviridis ENSTNIG00000006493 D 0.787
KDM2B Homo sapiens ENSG00000089094 D 0.895
KDM2A Tupaia belangeri ENSTBEG00000003398 I 1.000
KDM2A Sorex araneus ENSSARG00000001832 I 1.000
Kdm2b Rattus norvegicus ENSRNOG00000025702 I 0.787
Kdm2a Rattus norvegicus ENSRNOG00000019145 I 1.000
Fbxl19 Rattus norvegicus ENSRNOG00000018986 I 0.830
KDM2A Taeniopygia guttata ENSTGUG00000005980 I 0.957
KDM2B Taeniopygia guttata ENSTGUG00000006001 I 0.787
FBXL19 Pteropus vampyrus ENSPVAG00000011046 I 0.830
ENSSSCG00000009812 Sus scrofa ENSSSCG00000009812 I 0.787
KDM2B Sorex araneus ENSSARG00000008149 I 0.787
ENSSHAG00000000130 Sarcophilus harrisii ENSSHAG00000000130 I 1.000
ENSSHAG00000010625 Sarcophilus harrisii ENSSHAG00000010625 I 0.830
ENSSTOG00000027154 Ictidomys tridecemlineatus ENSSTOG00000027154 I 0.787
ENSSTOG00000005331 Ictidomys tridecemlineatus ENSSTOG00000005331 I 0.830
ENSSTOG00000003355 Ictidomys tridecemlineatus ENSSTOG00000003355 I 1.000
KDM2B Sus scrofa ENSSSCG00000029803 I 0.787
KDM2A Sus scrofa ENSSSCG00000029637 I 1.000
FBXL19 Sus scrofa ENSSSCG00000028186 I 0.830
KDM2B Tupaia belangeri ENSTBEG00000016315 I 0.787
ENSSHAG00000011039 Sarcophilus harrisii ENSSHAG00000011039 I 0.957
KDM2B Pteropus vampyrus ENSPVAG00000010258 I 0.787
KDM2A Pteropus vampyrus ENSPVAG00000008538 I 1.000
KDM2B Pan troglodytes ENSPTRG00000005560 I 0.787
FBXL19 Procavia capensis ENSPCAG00000010411 I 0.830
KDM2B Procavia capensis ENSPCAG00000007401 I 0.787
ENSPANG00000019062 Papio anubis ENSPANG00000019062 I 0.830
ENSPANG00000010984 Papio anubis ENSPANG00000010984 I 0.787
ENSPANG00000010861 Papio anubis ENSPANG00000010861 I 1.000
kdm2ba Oryzias latipes ENSORLG00000012943 I 0.787
kdm2aa Oryzias latipes ENSORLG00000011075 I 0.723
kdm2bb Oryzias latipes ENSORLG00000008562 I 0.787
FBXL19 Ochotona princeps ENSOPRG00000016023 I 0.830
KDM2B Ochotona princeps ENSOPRG00000015228 I 0.787
KDM2A Ochotona princeps ENSOPRG00000013564 I 1.000
KDM2A Procavia capensis ENSPCAG00000011177 I 1.000
ENSPFOG00000009817 Poecilia formosa ENSPFOG00000009817 I 0.702
KDM2A Pan troglodytes ENSPTRG00000003945 I 1.000
ENSPSIG00000004862 Pelodiscus sinensis ENSPSIG00000004862 I 0.787
ENSPSIG00000002317 Pelodiscus sinensis ENSPSIG00000002317 I 0.957
ENSPPYG00000007294 Pongo abelii ENSPPYG00000007294 I 0.830
ENSPPYG00000005050 Pongo abelii ENSPPYG00000005050 I 0.787
ENSPPYG00000003001 Pongo abelii ENSPPYG00000003001 I 1.000
ENSPMAG00000006989 Petromyzon marinus ENSPMAG00000006989 I 0.766
ENSPFOG00000021921 Poecilia formosa ENSPFOG00000021921 I 0.702
ENSPFOG00000019763 Poecilia formosa ENSPFOG00000019763 I 0.787
ENSPFOG00000016940 Poecilia formosa ENSPFOG00000016940 I 0.787
ENSPFOG00000011570 Poecilia formosa ENSPFOG00000011570 I 0.702
ENSONIG00000018158 Oreochromis niloticus ENSONIG00000018158 I 0.702
kdm2aa Tetraodon nigroviridis ENSTNIG00000003239 I 0.723
kdm2b.L Xenopus laevis XB-GENE-990512 I 0.787
Myotis_brandtii_FBXL19_10014496 Myotis brandtii Myotis_brandtii_FBXL19_10014496 I 0.830
Gfo_R013488 Geospiza fortis Gfo_R013488 I 0.957
Gfo_R003115 Geospiza fortis Gfo_R003115 I 0.787
ENSP00000384903 Macaca fascicularis ENSP00000384903 I 1.000
ENSP00000384903-D1 Bos grunniens ENSP00000384903-D1 I 1.000
ENSP00000369666 Macaca fascicularis ENSP00000369666 I 0.830
ENSP00000369666-D1 Bos grunniens ENSP00000369666-D1 I 0.830
ENSP00000366271 Macaca fascicularis ENSP00000366271 I 0.787
ENSP00000366271-D1 Bos grunniens ENSP00000366271-D1 I 0.787
Cmyd_10015637 Chelonia mydas Cmyd_10015637 I 0.787
Myotis_brandtii_KDM2A_10030797 Myotis brandtii Myotis_brandtii_KDM2A_10030797 I 1.000
Myotis_brandtii_KDM2B_10021721 Myotis brandtii Myotis_brandtii_KDM2B_10021721 I 0.787
kdm2b Xenopus tropicalis XB-GENE-990506 I 0.787
kdm2a Xenopus tropicalis XB-GENE-5900838 I 0.915
AAH82636 Xenopus laevis AAH82636 I 0.787
Tal_R002927 Tyto alba Tal_R002927 I 0.787
Pvit_16205 Pogona vitticeps Pvit_16205 I 0.957
Pvit_05626 Pogona vitticeps Pvit_05626 I 0.787
Pvit_05476 Pogona vitticeps Pvit_05476 I 0.809
Ogr08491 Ophisaurus gracilis Ogr08491 I 0.957
Ogr05591 Ophisaurus gracilis Ogr05591 I 0.809
Ogr01308 Ophisaurus gracilis Ogr01308 I 0.809
Cmyd_10001861 Chelonia mydas Cmyd_10001861 I 0.957
Brh_R009202 Buceros rhinoceros Brh_R009202 I 0.787
Alligator_sinensis_CCG016574.1 Alligator sinensis Alligator_sinensis_CCG016574.1 I 0.787
ENSXMAG00000015174 Xiphophorus maculatus ENSXMAG00000015174 I 0.787
ENSXMAG00000014057 Xiphophorus maculatus ENSXMAG00000014057 I 0.787
ENSXMAG00000009962 Xiphophorus maculatus ENSXMAG00000009962 I 0.702
KDM2A Vicugna pacos ENSVPAG00000010644 I 1.000
FBXL19 Tursiops truncatus ENSTTRG00000015474 I 0.830
ENSTSYG00000014726 Tarsius syrichta ENSTSYG00000014726 I 1.000
kdm2bb Takifugu rubripes ENSTRUG00000010230 I 0.787
kdm2aa Takifugu rubripes ENSTRUG00000005339 I 0.702
kdm2ba Takifugu rubripes ENSTRUG00000005276 I 0.895
FBXL19 Takifugu rubripes ENSTRUG00000000468 I 0.787
ENSXMAG00000015985 Xiphophorus maculatus ENSXMAG00000015985 I 0.702
ENSXMAG00000018857 Xiphophorus maculatus ENSXMAG00000018857 I 0.766
Alligator_sinensis_CCG006419.1 Alligator sinensis Alligator_sinensis_CCG006419.1 I 0.787
Alligator_sinensis_CCG000030.1 Alligator sinensis Alligator_sinensis_CCG000030.1 I 0.957
Afo_R005099 Aptenodytes forsteri Afo_R005099 I 0.957
Afo_R000853 Aptenodytes forsteri Afo_R000853 I 0.787
Aan_R013926 Calypte anna Aan_R013926 I 0.957
Aan_R010310 Calypte anna Aan_R010310 I 0.787
tetur13g02300 Tetranychus urticae tetur13g02300 I 0.745
SMAR015271 Strigamia maritima SMAR015271 I 0.702
ISCW018631 Ixodes scapularis ISCW018631 I 0.745
HelroG180456 Helobdella robusta HelroG180456 I 0.723
ENSTNIG00000009085 Tetraodon nigroviridis ENSTNIG00000009085 I 0.787
ENSONIG00000013875 Oreochromis niloticus ENSONIG00000013875 I 0.787
FBXL19 Gasterosteus aculeatus ENSGACG00000014763 I 0.787
FBXL19 Equus caballus ENSECAG00000018851 I 0.830
Fbxl19 Dipodomys ordii ENSDORG00000010635 I 0.830
ENSDORG00000006710 Dipodomys ordii ENSDORG00000006710 I 0.787
FBXL19 Dasypus novemcinctus ENSDNOG00000035206 I 0.830
KDM2B Dasypus novemcinctus ENSDNOG00000013082 I 0.787
KDM2A Dasypus novemcinctus ENSDNOG00000002051 I 1.000
kdm2ab Danio rerio ENSDARG00000078133 I 0.723
kdm2bb Danio rerio ENSDARG00000046010 I 0.766
ENSCSAG00000008476 Chlorocebus sabaeus ENSCSAG00000008476 I 1.000
ENSCSAG00000005806 Chlorocebus sabaeus ENSCSAG00000005806 I 0.830
KDM2B Equus caballus ENSECAG00000021840 I 0.787
KDM2A Equus caballus ENSECAG00000025072 I 1.000
kdm2ba Gasterosteus aculeatus ENSGACG00000011854 I 0.787
FBXL19 Homo sapiens ENSG00000099364 I 0.830
KDM2B Felis catus ENSFCAG00000012455 I 0.787
KDM2A Felis catus ENSFCAG00000003383 I 1.000
FBXL19 Felis catus ENSFCAG00000002585 I 0.830
ENSFALG00000012392 Ficedula albicollis ENSFALG00000012392 I 0.957
ENSFALG00000009151 Ficedula albicollis ENSFALG00000009151 I 0.787
KDM2A Echinops telfairi ENSETEG00000009328 I 1.000
KDM2A Erinaceus europaeus ENSEEUG00000010174 I 1.000
ENSCSAG00000002201 Chlorocebus sabaeus ENSCSAG00000002201 I 0.787
FBXL19 Cavia porcellus ENSCPOG00000022362 I 0.830
KDM2B Cavia porcellus ENSCPOG00000011011 I 0.787
ENSAPLG00000003636 Anas platyrhynchos ENSAPLG00000003636 I 0.957
ENSAMXG00000020635 Astyanax mexicanus ENSAMXG00000020635 I 0.745
ENSAMXG00000009823 Astyanax mexicanus ENSAMXG00000009823 I 0.702
ENSAMXG00000008005 Astyanax mexicanus ENSAMXG00000008005 I 0.787
ENSAMXG00000005838 Astyanax mexicanus ENSAMXG00000005838 I 0.809
ENSAMEG00000014308 Ailuropoda melanoleuca ENSAMEG00000014308 I 0.787
ENSAMEG00000007582 Ailuropoda melanoleuca ENSAMEG00000007582 I 0.830
ENSAMEG00000000531 Ailuropoda melanoleuca ENSAMEG00000000531 I 1.000
FBXL19 Anolis carolinensis ENSACAG00000007651 I 0.809
KDM2A Anolis carolinensis ENSACAG00000007630 I 0.957
ENSAPLG00000004534 Anas platyrhynchos ENSAPLG00000004534 I 0.787
KDM2B Bos taurus ENSBTAG00000002328 I 0.787
KDM2A Cavia porcellus ENSCPOG00000007134 I 1.000
FBXL19 Callithrix jacchus ENSCJAG00000002985 I 0.830
KDM2B Callithrix jacchus ENSCJAG00000001555 I 0.895
KDM2A Callithrix jacchus ENSCJAG00000001071 I 1.000
KDM2A Choloepus hoffmanni ENSCHOG00000006440 I 1.000
FBXL19 Canis familiaris ENSCAFG00000016736 I 0.830
KDM2A Canis familiaris ENSCAFG00000011792 I 1.000
KDM2B Canis familiaris ENSCAFG00000008259 I 0.787
KDM2A Bos taurus ENSBTAG00000044032 I 1.000
FBXL19 Bos taurus ENSBTAG00000040555 I 0.830
ACYPI010029 Acyrthosiphon pisum ACYPI010029 I 0.702
kdm2aa Gasterosteus aculeatus ENSGACG00000016421 I 0.702
ENSONIG00000010829 Oreochromis niloticus ENSONIG00000010829 I 0.787
ENSNLEG00000006301 Nomascus leucogenys ENSNLEG00000006301 I 1.000
Kdm2a Mus musculus ENSMUSG00000054611 I 1.000
Fbxl19 Mus musculus ENSMUSG00000030811 I 0.830
Kdm2b Mus musculus ENSMUSG00000029475 I 0.787
ENSMPUG00000011968 Mustela putorius furo ENSMPUG00000011968 I 0.830
ENSMPUG00000003692 Mustela putorius furo ENSMPUG00000003692 I 1.000
ENSMPUG00000002104 Mustela putorius furo ENSMPUG00000002104 I 0.787
ENSMODG00000012065 Monodelphis domestica ENSMODG00000012065 I 0.787
ENSMODG00000009064 Monodelphis domestica ENSMODG00000009064 I 0.957
KDM2A Monodelphis domestica ENSMODG00000007767 I 1.000
ENSNLEG00000016063 Nomascus leucogenys ENSNLEG00000016063 I 0.830
ENSNLEG00000016168 Nomascus leucogenys ENSNLEG00000016168 I 0.787
ENSONIG00000009273 Oreochromis niloticus ENSONIG00000009273 I 0.787
ENSOGAG00000033216 Otolemur garnettii ENSOGAG00000033216 I 0.745
FBXL19 Otolemur garnettii ENSOGAG00000014408 I 0.830
KDM2A Otolemur garnettii ENSOGAG00000010623 I 1.000
KDM2B Otolemur garnettii ENSOGAG00000000881 I 0.787
FBXL19 Oryctolagus cuniculus ENSOCUG00000010641 I 0.830
KDM2A Oryctolagus cuniculus ENSOCUG00000009988 I 1.000
KDM2B Oryctolagus cuniculus ENSOCUG00000005961 I 0.787
ENSOARG00000009415 Ovis aries ENSOARG00000009415 I 1.000
ENSOARG00000008120 Ovis aries ENSOARG00000008120 I 0.830
KDM2B Macaca mulatta ENSMMUG00000021564 I 0.787
KDM2A Macaca mulatta ENSMMUG00000008771 I 1.000
KDM2B Myotis lucifugus ENSMLUG00000013315 I 0.787
ENSLACG00000018441 Latimeria chalumnae ENSLACG00000018441 I 0.787
ENSLACG00000012832 Latimeria chalumnae ENSLACG00000012832 I 0.872
ENSLACG00000006471 Latimeria chalumnae ENSLACG00000006471 I 0.787
ENSGMOG00000015869 Gadus morhua ENSGMOG00000015869 I 0.787
ENSGMOG00000011590 Gadus morhua ENSGMOG00000011590 I 0.787
KDM2B Gorilla gorilla ENSGGOG00000014021 I 0.787
FBXL19 Gorilla gorilla ENSGGOG00000003625 I 0.787
KDM2A Gorilla gorilla ENSGGOG00000001636 I 1.000
ENSGALG00000013286 Gallus gallus ENSGALG00000013286 I 0.957
ENSGALG00000004225 Gallus gallus ENSGALG00000004225 I 0.787
KDM2A Loxodonta africana ENSLAFG00000006277 I 1.000
KDM2B Loxodonta africana ENSLAFG00000027865 I 0.787
KDM2A Myotis lucifugus ENSMLUG00000005065 I 1.000
KDM2B Microcebus murinus ENSMICG00000015572 I 0.787
KDM2A Microcebus murinus ENSMICG00000004044 I 1.000
KDM2B Meleagris gallopavo ENSMGAG00000004301 I 0.787
ENSMEUG00000004320 Macropus eugenii ENSMEUG00000004320 I 1.000
ENSMEUG00000003370 Macropus eugenii ENSMEUG00000003370 I 0.830
ENSMEUG00000001808 Macropus eugenii ENSMEUG00000001808 I 0.787
ENSLOCG00000008268 Lepisosteus oculatus ENSLOCG00000008268 I 0.745
ENSLOCG00000005104 Lepisosteus oculatus ENSLOCG00000005104 I 0.787
FBXL19 Loxodonta africana ENSLAFG00000030638 I 0.830
kdm2bb Gasterosteus aculeatus ENSGACG00000017026 I 0.787