| NCBI Gene Info:Enables oxidative DNA demethylase activity. Involved in germ cell development; nucleic acid metabolic process; and positive regulation of nucleobase-containing compound metabolic process. Located in nucleus. Is expressed in several structures, including ectoderm; embryonic/larval nervous system; extended germ band embryo; gonad; and larval imaginal tissue. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to several human genes including TET1 (tet methylcytosine dioxygenase 1). [provided by Alliance of Genome Resources, Apr 2022] |