ENSP00000352516 (Macaca fascicularis)
CxxC

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF02008 (zf-CXXC) IPR002857 ENSP00000352516 T168595_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
DNMT1
M01913_2.00
Homo sapiens
NNNNNCGGNN

NNCCGNNNNN
PBM
Weirauch et al.(2014)
pTH7029
1.000 1.000
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000352516 CxxC 570 616

Links

Other CxxC family TFs
Other Macaca fascicularis TFs

87 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
DNMT1 Macaca mulatta ENSMMUG00000014604 I 1.000
ENSNLEG00000012092 Nomascus leucogenys ENSNLEG00000012092 I 1.000
DNMT1 Microcebus murinus ENSMICG00000010231 I 1.000
DNMT1 Vicugna pacos ENSVPAG00000006117 I 1.000
DNMT1 Felis catus ENSFCAG00000012246 I 1.000
DNMT1 Homo sapiens ENSG00000130816 D 1.000
ENSOCUG00000008415 Oryctolagus cuniculus ENSOCUG00000008415 I 1.000
ENSPANG00000001264 Papio anubis ENSPANG00000001264 I 1.000
DNMT1 Pan troglodytes ENSPTRG00000010461 I 1.000
DNMT1 Pteropus vampyrus ENSPVAG00000003676 I 1.000
ENSPPYG00000009545 Pongo abelii ENSPPYG00000009545 I 1.000
DNMT1 Sus scrofa ENSSSCG00000013659 I 1.000
DNMT1 Procavia capensis ENSPCAG00000011023 I 1.000
DNMT1 Equus caballus ENSECAG00000026909 I 1.000
DNMT1 Gorilla gorilla ENSGGOG00000016574 I 1.000
ENSCSAG00000007378 Chlorocebus sabaeus ENSCSAG00000007378 I 1.000
DNMT1 Callithrix jacchus ENSCJAG00000005794 I 1.000
DNMT1 Canis familiaris ENSCAFG00000017892 I 0.979
DNMT1 Loxodonta africana ENSLAFG00000002818 I 0.979
ENSMPUG00000006829 Mustela putorius furo ENSMPUG00000006829 I 0.979
DNMT1 Otolemur garnettii ENSOGAG00000001265 I 0.979
DNMT1 Ochotona princeps ENSOPRG00000007032 I 0.979
ENSAMEG00000011823 Ailuropoda melanoleuca ENSAMEG00000011823 I 0.979
DNMT1 Dasypus novemcinctus ENSDNOG00000003313 I 0.979
ENSOARG00000015380 Ovis aries ENSOARG00000015380 I 0.957
ENSP00000352516-D1 Bos grunniens ENSP00000352516-D1 I 0.957
DNMT1 Tursiops truncatus ENSTTRG00000003178 I 0.957
ENSSTOG00000010841 Ictidomys tridecemlineatus ENSSTOG00000010841 I 0.957
DNMT1 Bos taurus ENSBTAG00000002736 I 0.957
ENSOANG00000012255 Ornithorhynchus anatinus ENSOANG00000012255 I 0.936
Myotis_brandtii_DNMT1_10007965 Myotis brandtii Myotis_brandtii_DNMT1_10007965 I 0.915
Dnmt1 Mus musculus ENSMUSG00000004099 I 0.915
DNMT1 Monodelphis domestica ENSMODG00000005463 I 0.915
DNMT1 Cavia porcellus ENSCPOG00000019557 I 0.915
DNMT1 Myotis lucifugus ENSMLUG00000001347 I 0.915
Alligator_sinensis_CCG017947.1 Alligator sinensis Alligator_sinensis_CCG017947.1 I 0.894
DNMT1 Echinops telfairi ENSETEG00000012574 I 0.894
ENSSHAG00000008894 Sarcophilus harrisii ENSSHAG00000008894 I 0.894
Ogr12994 Ophisaurus gracilis Ogr12994 I 0.894
Afo_R010037 Aptenodytes forsteri Afo_R010037 I 0.894
ENSFALG00000007760 Ficedula albicollis ENSFALG00000007760 I 0.894
ENSGALG00000028997 Gallus gallus ENSGALG00000028997 I 0.894
ENSMEUG00000012650 Macropus eugenii ENSMEUG00000012650 I 0.894
Dnmt1 Rattus norvegicus ENSRNOG00000039859 I 0.894
Gfo_R002685 Geospiza fortis Gfo_R002685 I 0.872
Aan_R006371 Calypte anna Aan_R006371 I 0.872
ENSPSIG00000002916 Pelodiscus sinensis ENSPSIG00000002916 I 0.872
Pvit_03471 Pogona vitticeps Pvit_03471 I 0.851
Dnmt1 Dipodomys ordii ENSDORG00000014116 I 0.851
DNMT1 Choloepus hoffmanni ENSCHOG00000009490 I 0.851
Cmyd_10002310 Chelonia mydas Cmyd_10002310 I 0.851
Sakowv30005306m.g Saccoglossus kowalevskii Sakowv30005306m.g I 0.809
dnmt1 Oryzias latipes ENSORLG00000005582 I 0.809
DNMT1 Anolis carolinensis ENSACAG00000003948 I 0.809
ENSONIG00000001574 Oreochromis niloticus ENSONIG00000001574 I 0.787
dnmt1 Danio rerio ENSDARG00000030756 I 0.787
dnmt1 Xenopus tropicalis XB-GENE-965562 I 0.787
ENSLOCG00000007421 Lepisosteus oculatus ENSLOCG00000007421 I 0.787
Ocbimv22034501m.g Octopus bimaculoides Ocbimv22034501m.g I 0.766
ENSAMXG00000012182 Astyanax mexicanus ENSAMXG00000012182 I 0.766
dnmt1.S Xenopus laevis XB-GENE-17332488 I 0.766
ENSXMAG00000018063 Xiphophorus maculatus ENSXMAG00000018063 I 0.766
Aqu1.203581 Amphimedon queenslandica Aqu1.203581 I 0.766
dnmt1.L Xenopus laevis XB-GENE-965566 I 0.766
ENSTGUG00000013708 Taeniopygia guttata ENSTGUG00000013708 I 0.766
ENSPFOG00000005624 Poecilia formosa ENSPFOG00000005624 I 0.766
CGI_10021920 Crassostrea gigas CGI_10021920 I 0.745
Aqu1.224590 Amphimedon queenslandica Aqu1.224590 I 0.745
Aqu1.204705 Amphimedon queenslandica Aqu1.204705 I 0.745
CapteG160905 Capitella teleta CapteG160905 I 0.745
ENSGMOG00000003491 Gadus morhua ENSGMOG00000003491 I 0.745
HelroG116156 Helobdella robusta HelroG116156 I 0.745
dnmt1 Takifugu rubripes ENSTRUG00000008132 I 0.745
dnmt1 Tetraodon nigroviridis ENSTNIG00000018567 I 0.745
NV11649 Nasonia vitripennis NV11649 I 0.745
GB47348 Apis mellifera GB47348 I 0.723
dnmt1 Gasterosteus aculeatus ENSGACG00000013741 I 0.723
GB48403 Apis mellifera GB48403 I 0.723
LotgiG171288 Lottia gigantea LotgiG171288 I 0.723
Cflo_12808--XP_001122269.1_APIME Camponotus floridanus Cflo_12808--XP_001122269.1_APIME I 0.723
NEMVEDRAFT_v1g125496 Nematostella vectensis NEMVEDRAFT_v1g125496 I 0.723
ENSPMAG00000002148 Petromyzon marinus ENSPMAG00000002148 I 0.723
XP_002155714.1 Hydra magnipapillata XP_002155714.1 I 0.702
Brh_R005100 Buceros rhinoceros Brh_R005100 I 0.702
e_gw.24.105.1 Branchiostoma floridae e_gw.24.105.1 I 0.702
ENSCSAVG00000006002 Ciona savignyi ENSCSAVG00000006002 I 0.702
ISCW001108 Ixodes scapularis ISCW001108 I 0.702