E2F7 (Homo sapiens)
E2F

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02319 (E2F_TDP) IPR003316 ENSG00000165891 T172621_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity; cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; regulation of transcription, DNA-templated; and sprouting angiogenesis. Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
E2F7
M02960_2.00		 Homo sapiens
WTTTGGCGGGAAAH
DTTTCCCGCCAAAW		 SELEX
Jolma et al.(2013)
E2F7_1		 (Direct) (Direct)
E2F7
M04705_2.00		 Homo sapiens
WTTTGGCGGGAAAN
NTTTCCCGCCAAAW		 SELEX
Yin et al.(2017)
E2F7_eDBD_HT-SELEX		 (Direct) (Direct)
E2F7
M04706_2.00		 Homo sapiens
WTTTGGCGGGAAAH
DTTTCCCGCCAAAW		 SELEX
Yin et al.(2017)
E2F7_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)
E2F7
M09033_2.00		 Homo sapiens
NDGGCGGGRRNDV
BHNYYCCCGCCHN		 Misc
Kulakovskiy et al.(2013)
E2F7_HUMAN.H11MO.0.B		 (Direct) (Direct)
E2F7
M09522_2.00		 Homo sapiens
NSGCGSGAAMNN
NNKTTCSCGCSN		 Misc
Heinz et al.(2010)
Hela-E2F7_GSE32673		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
E2f7
M09040_2.00 		Mus musculus
NDGGCGGGRRNDV
BHNYYCCCGCCHN		 Misc
Kulakovskiy et al.(2013)
E2F7_MOUSE.H11MO.0.C 		1.000 1.000
E2F8
M02959_2.00 		Homo sapiens
TTTGGCGGGAAA
TTTCCCGCCAAA		 SELEX
Jolma et al.(2013)
E2F8_1 		0.801 0.801
E2F8
M04703_2.00 		Homo sapiens
WDKTGGCGGGARNN
NNYTCCCGCCAMHW		 SELEX
Yin et al.(2017)
E2F8_eDBD_HT-SELEX 		0.801 0.801
E2F8
M04704_2.00 		Homo sapiens
WTTTGGCGGGAAWN
NWTTCCCGCCAAAW		 SELEX
Yin et al.(2017)
E2F8_eDBD_Methyl-HT-SELEX 		0.801 0.801
E2FE
M01958_2.00 		Arabidopsis thaliana
HDSGCGCSHD
HDSGCGCSHD		 PBM
Weirauch et al.(2014)
pTH8176 		0.596 0.596
E2FE
M06873_2.00 		Arabidopsis thaliana
TTTTGGCGGGAAAWWNWNDDN
NHHNWNWWTTTCCCGCCAAAA		 Dap-seq
OMalley et al.(2016)
DEL1_col_a 		0.596 0.596
E2FE
M06874_2.00 		Arabidopsis thaliana
DTTTTGGCGGGAAAA
TTTTCCCGCCAAAAH		 Dap-seq
OMalley et al.(2016)
DEL1_colamp_a 		0.596 0.596
E2FD
M06875_2.00 		Arabidopsis thaliana
DWWHDDTTTTGGCGGGAAAW
WTTTCCCGCCAAAAHHDWWH		 Dap-seq
OMalley et al.(2016)
DEL2_col_a 		0.529 0.529
E2FD
M06876_2.00 		Arabidopsis thaliana
DTTTTGGCGGGAAAA
TTTTCCCGCCAAAAH		 Dap-seq
OMalley et al.(2016)
DEL2_colamp_a 		0.529 0.529
E2FD
M10442_2.00 		Arabidopsis thaliana Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
P$E2L1_Q2 		0.529 0.529
E2FD
M10443_2.00 		Arabidopsis thaliana Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
P$E2L_Q2 		0.529 0.529
For this family, TFs with SR scores > 0.429 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000323246 E2F 143 211
ENSP00000323246 E2F 283 367
ENSP00000393639 E2F 143 211
ENSP00000393639 E2F 283 367
ENSP00000447963 E2F 19 87
ENSP00000447963 E2F 159 206
ENSP00000448245 E2F 143 211
ENSP00000448245 E2F 283 367
ENSP00000449284 E2F 21 89
ENSP00000449284 E2F 161 209

Links

Other E2F family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

357 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action