|
ENSP00000256117-D1
(Bos grunniens)
E2F
|
TF Information |
Pfam ID |
Interpro ID |
Gene ID |
CIS-BP ID |
Sequence source |
PF02319 (E2F_TDP) |
IPR003316 |
ENSP00000256117-D1 |
T173717_2.00 |
GigaDB (2015-Oct-22) |
NCBI Gene Info:This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016] |
Directly determined binding motifs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
No direct experiments |
|
|
|
|
|
Motifs from related TFs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
E2f5
M09042_2.00 |
Mus musculus |
NGCGCSAAAN |
NTTTSGCGCN |
Misc
Kulakovskiy et al.(2013)
E2F5_MOUSE.H11MO.0.B
|
0.872
|
0.872
|
E2F4
M02961_2.00 |
Homo sapiens |
AATGGCGCCAAA |
TTTGGCGCCATT |
SELEX
Jolma et al.(2013)
E2F4_1
|
0.851
|
0.851
|
E2F4
M02962_2.00 |
Homo sapiens |
TTTGGCGCCAAA |
TTTGGCGCCAAA |
SELEX
Jolma et al.(2013)
E2F4_2
|
0.851
|
0.851
|
E2F4
M04707_2.00 |
Homo sapiens |
NWWKGGCGCCAAAW |
WTTTGGCGCCMWWN |
SELEX
Yin et al.(2017)
E2F4_eDBD_HT-SELEX
|
0.851
|
0.851
|
E2F4
M08109_2.00 |
Homo sapiens |
NSGCGGGARVN |
NBYTCCCGCSN |
ChIP-seq
Mathelier et al.(2014)
MA0470.1
|
0.851
|
0.851
|
E2F4
M07942_2.00 |
Homo sapiens |
SGCGSGARDNNBNVN |
NBNVNNHYTCSCGCS |
ChIP-seq
Gerstein et al.(2012)
HeLa-S3_E2F4_UCD
|
0.851
|
0.851
|
E2F4
M07943_2.00 |
Homo sapiens |
SGCGGGARDNNBVVN |
NBBVNNHYTCCCGCS |
ChIP-seq
Gerstein et al.(2012)
K562b_E2F4_UCD
|
0.851
|
0.851
|
E2F4
M09036_2.00 |
Homo sapiens |
VDRGGCGGGRVND |
HNBYCCCGCCYHB |
Misc
Kulakovskiy et al.(2013)
E2F4_HUMAN.H11MO.0.A
|
0.851
|
0.851
|
E2f4
M09037_2.00 |
Mus musculus |
NRDDGGCGGGRMNN |
NNKYCCCGCCHHYN |
Misc
Kulakovskiy et al.(2013)
E2F4_MOUSE.H11MO.0.A
|
0.851
|
0.851
|
E2F4
M09524_2.00 |
Homo sapiens |
VGCGSGAADH |
DHTTCSCGCB |
Misc
Heinz et al.(2010)
K562-E2F4_GSE31477
|
0.851
|
0.851
|
E2F4
M10457_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$E2F4_05
|
0.851
|
0.851
|
E2F4
M10458_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$E2F4_Q3
|
0.851
|
0.851
|
E2F4
M10459_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$E2F4_Q6
|
0.851
|
0.851
|
e_gw1.38.2.1
M01968_2.00 |
Physcomitrella patens |
NSGCGCBHHN |
NDDVGCGCSN |
PBM
Weirauch et al.(2014)
pTH5707
|
0.745
|
0.745
|
estExt_gwp_gw1.C_220046
M01225_2.00 |
Physcomitrella patens |
VGCGCBHHNN |
NNDDVGCGCB |
PBM
Lambert et al.(2019)
pTH9809
|
0.745
|
0.745
|
E2F2
M01963_2.00 |
Tupaia belangeri |
WDVGCGCBHW |
WDVGCGCBHW |
PBM
Weirauch et al.(2014)
pTH9291
|
0.723
|
0.723
|
E2FA
M06871_2.00 |
Arabidopsis thaliana |
NDDDGGCGCCAWWW |
WWWTGGCGCCHHHN |
Dap-seq
OMalley et al.(2016)
E2FA_col_a
|
0.723
|
0.723
|
E2FA
M06872_2.00 |
Arabidopsis thaliana |
DDWDGGCGCCAWAD |
HTWTGGCGCCHWHH |
Dap-seq
OMalley et al.(2016)
E2FA_colamp_a
|
0.723
|
0.723
|
E2FA
M08106_2.00 |
Arabidopsis thaliana |
NVGCGCCAHN |
NDTGGCGCBN |
ChIP-seq
Mathelier et al.(2014)
MA1414.1
|
0.723
|
0.723
|
ENSACAG00000013716
M01960_2.00 |
Anolis carolinensis |
HNVGCGCBND |
HNVGCGCBND |
PBM
Weirauch et al.(2014)
pTH9221
|
0.702
|
0.702
|
E2f2
M00154_2.00 |
Mus musculus |
NDNNGCGSBN |
NVSCGCNNHN |
PBM
Badis et al.(2009)
E2F2_1022
|
0.702
|
0.702
|
ENSOANG00000014967
M01962_2.00 |
Ornithorhynchus anatinus |
NDSGCGCSHN |
NDSGCGCSHN |
PBM
Weirauch et al.(2014)
pTH9382
|
0.702
|
0.702
|
E2F3
M01964_2.00 |
Taeniopygia guttata |
NNSGCGCGMN |
NKCGCGCSNN |
PBM
Weirauch et al.(2014)
pTH9288
|
0.702
|
0.702
|
E2f2
M09039_2.00 |
Mus musculus |
GGCGCGMAWC |
GWTKCGCGCC |
Misc
Kulakovskiy et al.(2013)
E2F2_MOUSE.H11MO.0.B
|
0.702
|
0.702
|
E2F2
M01961_2.00 |
Homo sapiens |
DNSGCGCSNH |
DNSGCGCSNH |
PBM
Weirauch et al.(2014)
pTH9195
|
0.681
|
0.681
|
E2f3
M00153_2.00 |
Mus musculus |
NNNNGCGSNN |
NNSCGCNNNN |
PBM
Badis et al.(2009)
E2F3_3752
|
0.681
|
0.681
|
E2F1
M02952_2.00 |
Homo sapiens |
WWDGGCGCCAAW |
WTTGGCGCCHWW |
SELEX
Jolma et al.(2013)
E2F1_1
|
0.681
|
0.681
|
E2F1
M02953_2.00 |
Homo sapiens |
WWKGGCGCCWWW |
WWWGGCGCCMWW |
SELEX
Jolma et al.(2013)
E2F1_2
|
0.681
|
0.681
|
E2F1
M02954_2.00 |
Homo sapiens |
WWWKGGCGCCMWWW |
WWWKGGCGCCMWWW |
SELEX
Jolma et al.(2013)
E2F1_3
|
0.681
|
0.681
|
E2F1
M02955_2.00 |
Homo sapiens |
AAWKGGCGCCAWTW |
WAWTGGCGCCMWTT |
SELEX
Jolma et al.(2013)
E2F1_4
|
0.681
|
0.681
|
E2F2
M02949_2.00 |
Homo sapiens |
AAAAATGGCGCCAAAAWD |
HWTTTTGGCGCCATTTTT |
SELEX
Jolma et al.(2013)
E2F2_1
|
0.681
|
0.681
|
E2F2
M02950_2.00 |
Homo sapiens |
VDTTTTGGCGCCAAAAHN |
NDTTTTGGCGCCAAAAHB |
SELEX
Jolma et al.(2013)
E2F2_2
|
0.681
|
0.681
|
E2F2
M02951_2.00 |
Homo sapiens |
AAAWWGGCGCCAWTTT |
AAAWTGGCGCCWWTTT |
SELEX
Jolma et al.(2013)
E2F2_3
|
0.681
|
0.681
|
E2F3
M02956_2.00 |
Homo sapiens |
RAAAAKGGCGCCAAAANN |
NNTTTTGGCGCCMTTTTY |
SELEX
Jolma et al.(2013)
E2F3_1
|
0.681
|
0.681
|
E2F3
M02957_2.00 |
Homo sapiens |
DAAAADGGCGCCMWWTTY |
RAAWWKGGCGCCHTTTTH |
SELEX
Jolma et al.(2013)
E2F3_2
|
0.681
|
0.681
|
E2F3
M02958_2.00 |
Homo sapiens |
NDTTTTGGCGCCAAAABH |
DVTTTTGGCGCCAAAAHN |
SELEX
Jolma et al.(2013)
E2F3_3
|
0.681
|
0.681
|
E2F1
M04700_2.00 |
Homo sapiens |
NWWWDGGCGCCAAAWH |
DWTTTGGCGCCHWWWN |
SELEX
Yin et al.(2017)
E2F1_FL_HT-SELEX
|
0.681
|
0.681
|
E2F3
M04701_2.00 |
Homo sapiens |
DWTTTGGCGCCAAAWH |
DWTTTGGCGCCAAAWH |
SELEX
Yin et al.(2017)
E2F3_eDBD_HT-SELEX
|
0.681
|
0.681
|
E2F2
M04696_2.00 |
Homo sapiens |
GCGCGCGCSYW |
WRSGCGCGCGC |
SELEX
Yin et al.(2017)
E2F2_eDBD_HT-SELEX_1
|
0.681
|
0.681
|
E2F2
M04697_2.00 |
Homo sapiens |
NDWWDGGCGCCWWHWN |
NWDWWGGCGCCHWWHN |
SELEX
Yin et al.(2017)
E2F2_eDBD_HT-SELEX_2
|
0.681
|
0.681
|
E2F1
M07938_2.00 |
Homo sapiens |
VRRVNRVGCGSGMDS |
SHKCSCGCBYNBYYB |
ChIP-seq
Gerstein et al.(2012)
HeLa-S3_E2F1_UCD
|
0.681
|
0.681
|
E2F1
M09030_2.00 |
Homo sapiens |
NVNDGGCGGGARVN |
NBYTCCCGCCHNBN |
Misc
Kulakovskiy et al.(2013)
E2F1_HUMAN.H11MO.0.A
|
0.681
|
0.681
|
E2F2
M09029_2.00 |
Homo sapiens |
GGCGCGMAWC |
GWTKCGCGCC |
Misc
Kulakovskiy et al.(2013)
E2F2_HUMAN.H11MO.0.B
|
0.681
|
0.681
|
E2F3
M09031_2.00 |
Homo sapiens |
NDGGCGGGAAR |
YTTCCCGCCHN |
Misc
Kulakovskiy et al.(2013)
E2F3_HUMAN.H11MO.0.A
|
0.681
|
0.681
|
E2f1
M09041_2.00 |
Mus musculus |
NDDGGCGGGRVN |
NBYCCCGCCHHN |
Misc
Kulakovskiy et al.(2013)
E2F1_MOUSE.H11MO.0.A
|
0.681
|
0.681
|
E2f3
M09038_2.00 |
Mus musculus |
DSGCGGGARV |
BYTCCCGCSH |
Misc
Kulakovskiy et al.(2013)
E2F3_MOUSE.H11MO.0.A
|
0.681
|
0.681
|
E2F1
M09521_2.00 |
Homo sapiens |
NNGGCGGGAA |
TTCCCGCCNN |
Misc
Heinz et al.(2010)
Hela-E2F1_GSE22478
|
0.681
|
0.681
|
E2F1
M10444_2.00 |
Homo sapiens |
THVGCGCGAAAAHKR |
YMDTTTTCGCGCBDA |
Transfac
Matys et al.(2006)
V$E2F_01
|
0.681
|
0.681
|
E2F1
M10445_2.00 |
Homo sapiens |
BHKSGCGCSAAA |
TTTSGCGCSMDV |
Transfac
Matys et al.(2006)
V$E2F_03
|
0.681
|
0.681
|
E2F1
M10446_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$E2F1_01
|
0.681
|
0.681
|
E2F1
M10447_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$E2F1_02
|
0.681
|
0.681
|
E2F1
M10448_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$E2F1_Q3_01
|
0.681
|
0.681
|
E2F1
M10449_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$E2F1_Q3
|
0.681
|
0.681
|
E2F1
M10450_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$E2F1_Q4_01
|
0.681
|
0.681
|
E2F1
M10451_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$E2F1_Q4_02
|
0.681
|
0.681
|
E2F1
M10452_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$E2F1_Q4
|
0.681
|
0.681
|
E2F3
M10454_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$E2F1_Q6_01
|
0.681
|
0.681
|
E2F1
M10453_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$E2F1_Q6
|
0.681
|
0.681
|
E2F3
M10455_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$E2F3_Q6
|
0.681
|
0.681
|
E2F3
M04702_2.00 |
Homo sapiens |
DTTTTGGCGCCAAAAH |
DTTTTGGCGCCAAAAH |
SELEX
Yin et al.(2017)
E2F3_eDBD_Methyl-HT-SELEX
|
0.681
|
0.681
|
E2F2
M04698_2.00 |
Homo sapiens |
SGBGSGCGCGS |
SCGCGCSCVCS |
SELEX
Yin et al.(2017)
E2F2_eDBD_Methyl-HT-SELEX_1
|
0.681
|
0.681
|
E2F2
M04699_2.00 |
Homo sapiens |
DWWWDGGCGCCAAAWH |
DWTTTGGCGCCHWWWH |
SELEX
Yin et al.(2017)
E2F2_eDBD_Methyl-HT-SELEX_2
|
0.681
|
0.681
|
E2FC
M06870_2.00 |
Arabidopsis thaliana |
AWDDDGGCGCCAAAR |
YTTTGGCGCCHHHWT |
Dap-seq
OMalley et al.(2016)
E2FC_col_a
|
0.660
|
0.660
|
efl-1
M08110_2.00 |
Caenorhabditis elegans |
HNHNSGCGSSAAWWN |
NWWTTSSCGCSNDND |
ChIP-seq
Mathelier et al.(2014)
MA0541.1
|
0.660
|
0.660
|
efl-1
M08197_2.00 |
Caenorhabditis elegans |
BGCGSSAAWW |
WWTTSSCGCV |
ChIP-seq
Contrino et al.(2012)
Mw140
|
0.660
|
0.660
|
efl-1
M09526_2.00 |
Caenorhabditis elegans |
WGCAARYGCGCTCYA |
TRGAGCGCRYTTGCW |
Misc
Heinz et al.(2010)
cElegans-L1-EFL1_modEncode
|
0.660
|
0.660
|
E2f
M08196_2.00 |
Drosophila melanogaster |
AAWWBSSCGSCAA |
TTGSCGSSVWWTT |
ChIP-seq
Contrino et al.(2012)
Mf10
|
0.617
|
0.617
|
E2F6
M08107_2.00 |
Homo sapiens |
DGGMGGGARVN |
NBYTCCCKCCH |
ChIP-seq
Mathelier et al.(2014)
MA0471.1
|
0.596
|
0.596
|
E2F6
M07939_2.00 |
Homo sapiens |
NDSGCGGGARV |
BYTCCCGCSHN |
ChIP-seq
Gerstein et al.(2012)
HeLa-S3_E2F6_UCD
|
0.596
|
0.596
|
E2F6
M07940_2.00 |
Homo sapiens |
NDVGCGGGARV |
BYTCCCGCBHN |
ChIP-seq
Gerstein et al.(2012)
K562b_E2F6_UCD
|
0.596
|
0.596
|
E2F6
M07941_2.00 |
Homo sapiens |
NDSGCGGGARV |
BYTCCCGCSHN |
ChIP-seq
Gerstein et al.(2012)
K562_E2F6_HudsonAlpha
|
0.596
|
0.596
|
E2F6
M09034_2.00 |
Homo sapiens |
NRGGMGGGARRNN |
NNYYTCCCKCCYN |
Misc
Kulakovskiy et al.(2013)
E2F6_HUMAN.H11MO.0.A
|
0.596
|
0.596
|
E2F6
M09523_2.00 |
Homo sapiens |
VGCGGGARNN |
NNYTCCCGCB |
Misc
Heinz et al.(2010)
Hela-E2F6_GSE31477
|
0.596
|
0.596
|
E2F6
M10456_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$E2F6_01
|
0.596
|
0.596
|
E2F
M01959_2.00 |
Dictyostelium discoideum |
NNGSGCGCSHN |
NDSGCGCSCNN |
PBM
Weirauch et al.(2014)
pTH5403
|
0.574
|
0.574
|
GSPATT00020286001
M01965_2.00 |
Paramecium tetraurelia |
NNSGCGSBN |
NVSCGCSNN |
PBM
Weirauch et al.(2014)
pTH5647
|
0.574
|
0.574
|
E2f6
M09043_2.00 |
Mus musculus |
NDGGCGGGARVV |
BBYTCCCGCCHN |
Misc
Kulakovskiy et al.(2013)
E2F6_MOUSE.H11MO.0.A
|
0.574
|
0.574
|
estExt_gwp_GeneWisePlus.C_Chr_02.00010270
M01969_2.00 |
Ostreococcus tauri |
HRVGCGCCNN |
NNGGCGCBYD |
PBM
Weirauch et al.(2014)
pTH5701
|
0.489
|
0.489
|
efl-2
M01966_2.00 |
Caenorhabditis elegans |
NDBGCGSBNN |
NNVSCGCVHN |
PBM
Weirauch et al.(2014)
pTH5916
|
0.447
|
0.447
|
efl-2
M00662_2.00 |
Caenorhabditis elegans |
NSGCGSNNDN |
NHNNSCGCSN |
PBM
Narasimhan et al.(2015)
pTH9173
|
0.447
|
0.447
|
For this family, TFs with SR scores > 0.429 will likely have a similar motif |