CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
Home
Tools
View cart
Bulk downloads
Database stats
Contact us
Help
Update Log
FAQ
Links
How to cite
EBF3
(
Homo sapiens
)
EBF1
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF16422 (COE1_DBD)
(none)
ENSG00000108001
T174552_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF proteins are involved in B-cell differentiation, bone development and neurogenesis, and may also function as tumor suppressors. The encoded protein inhibits cell survival through the regulation of genes involved in cell cycle arrest and apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple malignancies including glioblastoma multiforme and gastric carcinoma. [provided by RefSeq, Sep 2011]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
EBF3
M10461_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EBF_Q6
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Ebf1
M09045_2.00
Mus musculus
DBYCCCWRGGGAV
BTCCCYWGGGRVH
Misc
Kulakovskiy et al.(2013)
COE1_MOUSE.H11MO.0.A
0.952
0.952
Ebf1
M09527_2.00
Mus musculus
DBTCCCHDGGGA
TCCCHDGGGAVH
Misc
Heinz et al.(2010)
proBcell-EBF_GSE21978
0.952
0.952
Ebf1
M10469_2.00
Mus musculus
VYMHVYYCYYBRGGGAVTHKHB
VDMDABTCCCYVRRGRRBDKRB
Transfac
Matys et al.(2006)
V$OLF1_01
0.952
0.952
Ebf2
M10467_2.00
Mus musculus
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$COE2_01
0.883
0.883
Ebf4
M10468_2.00
Mus musculus
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EBF4_01
0.879
0.879
EBF4
M10460_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EBF4_02
0.879
0.879
kn
M03721_2.00
Drosophila melanogaster
BWATTCCCHDGGGAATWV
BWATTCCCHDGGGAATWV
SELEX
Nitta et al.(2015)
kn_1
0.740
0.740
For this family, TFs with SR scores >
0.700
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000347463
EBF1
17
247
EEPLGSGMNPVRSWMHTAGVVDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVEKEKEPNNEKTNNGIHYKLQLLYSNGVRTEQDLYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRL
ENSP00000357637
EBF1
17
247
EEPLGSGMNPVRSWMHTAGVVDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVEKEKEPNNEKTNNGIHYKLQLLYSNGVRTEQDLYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRL
Links
Other
EBF1
family TFs
Other
Homo sapiens
TFs
352 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy