ENSP00000227163 (Macaca fascicularis)
Ets

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00178 (Ets) IPR000418 ENSP00000227163 T177769_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Spi1
M00155_2.00
Mus musculus
NNNVGGAAVH

DBTTCCBNNN
PBM
Badis et al.(2009)
Sfpi1_1034
0.866 0.917
Spi1
M01475_2.00
Mus musculus
DDNVGGAASY

RSTTCCBNHH
PBM
Wei et al.(2010)
Sfpi1
0.866 0.917
SPI1
M02965_2.00
Homo sapiens
RAAAAGMGGAAGTW

WACTTCCKCTTTTY
SELEX
Jolma et al.(2013)
SPI1_1
0.866 0.917
SPI1
M07944_2.00
Homo sapiens
NRAAWGRGGAASTGRRANN

NNTYYCASTTCCYCWTTYN
ChIP-seq
Gerstein et al.(2012)
GM12878_PU1_HudsonAlpha
0.866 0.917
SPI1
M07945_2.00
Homo sapiens
AAWGRGGAASTGARAVHNN

NNDBTYTCASTTCCYCWTT
ChIP-seq
Gerstein et al.(2012)
GM12891_PU1_HudsonAlpha
0.866 0.917
SPI1
M07946_2.00
Homo sapiens
RRAAAGAGGAAGTGV

BCACTTCCTCTTTYY
ChIP-seq
Gerstein et al.(2012)
K562_PU1_HudsonAlpha
0.866 0.917
SPI1
M08026_2.00
Homo sapiens
VRAAWGRGGAAGTGV

BCACTTCCYCWTTYB
ChIP-seq
Chen et al.(2011)
SRP005406_SPI1
0.866 0.917
Spi1
M08027_2.00
Mus musculus
VRRAWRRGGAAGWVD

HBWCTTCCYYWTYYB
ChIP-seq
Chen et al.(2011)
GSE11329_Sfpi1
0.866 0.917
SPI1
M09047_2.00
Homo sapiens
VRAAWGRGGAAGTGRNN

NNYCACTTCCYCWTTYB
Misc
Kulakovskiy et al.(2013)
SPI1_HUMAN.H11MO.0.A
0.866 0.917
Spi1
M09065_2.00
Mus musculus
VRARWGRGGAAGTGV

BCACTTCCYCWYTYB
Misc
Kulakovskiy et al.(2013)
SPI1_MOUSE.H11MO.0.A
0.866 0.917
Spi1
M09538_2.00
Mus musculus
WGAGGAAGTG

CACTTCCTCW
Misc
Heinz et al.(2010)
ThioMac-PU.1_GSE21512
0.866 0.917
SPI1
M10472_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PU1_Q4
0.866 0.917
SPI1
M10473_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PU1_Q6
0.866 0.917
SPI1
M10474_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SPI1_01
0.866 0.917
SPI1
M10475_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SPI1_07
0.866 0.917
SPI1
M10476_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SPI1_08
0.866 0.917
SPI1
M10477_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SPI1_Q5
0.866 0.917
For this family, TFs with SR scores > 0.717 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000227163 Ets 172 207

Links

Other Ets family TFs
Other Macaca fascicularis TFs

132 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
spi1b Danio rerio ENSDARG00000000767 I 0.986
gabpa.S Xenopus laevis XB-GENE-17331756 I 0.959
SNAPOd2T00022291001 Oikopleura dioica SNAPOd2T00022291001 N 0.946
nDi.2.2.2.g11508 Dirofilaria immitis nDi.2.2.2.g11508 N 0.946
HMEL005115 Heliconius melpomene HMEL005115 N 0.946
Ehf Mus musculus ENSMUSG00000012350 D 0.946
HCOI00865000 Haemonchus contortus HCOI00865000 N 0.944
SVUK_0001517201 Strongylus vulgaris SVUK_0001517201 N 0.944
SPDEF Erinaceus europaeus ENSEEUG00000010400 N 0.937
ENSAPLG00000005437 Anas platyrhynchos ENSAPLG00000005437 I 0.937
SPDEF Danio rerio ENSDARG00000029930 N 0.937
HelroG189408 Helobdella robusta HelroG189408 N 0.936
HMEL013736 Heliconius melpomene HMEL013736 N 0.936
OESDEN_14003 Oesophagostomum dentatum OESDEN_14003 I 0.935
HPBE_0001740201 Heligmosomoides bakeri HPBE_0001740201 I 0.935
Spic Mus musculus ENSMUSG00000004359 D 0.933
ELK3 Homo sapiens ENSG00000111145 D 0.932
ENSTBEG00000017397 Tupaia belangeri ENSTBEG00000017397 I 0.932
OESDEN_02390 Oesophagostomum dentatum OESDEN_02390 I 0.932
ENSVPAG00000005650 Vicugna pacos ENSVPAG00000005650 I 0.932
ENSOANG00000021194 Ornithorhynchus anatinus ENSOANG00000021194 N 0.932
ETS2 Procavia capensis ENSPCAG00000001036 I 0.932
scaffold700-EXSNAP2012.3 Pristionchus exspectatus scaffold700-EXSNAP2012.3 N 0.931
Elf5 Mus musculus ENSMUSG00000027186 D 0.926
ETV6 Procavia capensis ENSPCAG00000016039 I 0.923
ENSTBEG00000014406 Tupaia belangeri ENSTBEG00000014406 I 0.923
ETV6 Echinops telfairi ENSETEG00000002501 I 0.923
Etv4 Dipodomys ordii ENSDORG00000013847 I 0.923
ENSVPAG00000009100 Vicugna pacos ENSVPAG00000009100 I 0.923
ENSMEUG00000003760 Macropus eugenii ENSMEUG00000003760 I 0.923
SPIC Echinops telfairi ENSETEG00000004217 N 0.922
SPDEF Dasypus novemcinctus ENSDNOG00000047693 N 0.921
ETV2 Sorex araneus ENSSARG00000010742 N 0.920
SPI1 Echinops telfairi ENSETEG00000000432 I 0.920
ETS1 Meleagris gallopavo ENSMGAG00000000967 I 0.917
ETS1 Dasypus novemcinctus ENSDNOG00000045506 I 0.915
ETS2 Felis catus ENSFCAG00000007489 I 0.915
ML46088a Mnemiopsis leidyi ML46088a N 0.908
DILT_0000398401 Diphyllobothrium latum DILT_0000398401 I 0.908
ENSMGAG00000003467 Meleagris gallopavo ENSMGAG00000003467 I 0.907
CpipJ_CPIJ001753 Culex pipiens CpipJ_CPIJ001753 N 0.904
SPER_0003941101 Spirometra erinaceieuropaei SPER_0003941101 I 0.904
CPIJ001753 Culex quinquefasciatus CPIJ001753 N 0.904
Gfo_R003012 Geospiza fortis Gfo_R003012 N 0.903
SPER_0001231601 Spirometra erinaceieuropaei SPER_0001231601 N 0.902
PXEA_0000391701 Protopolystoma xenopodis PXEA_0000391701 N 0.890
Alligator_sinensis_CCG000956.1 Alligator sinensis Alligator_sinensis_CCG000956.1 I 0.890
GPLIN_000810800 Globodera pallida GPLIN_000810800 N 0.886
SPI1 Sus scrofa ENSSSCG00000013237 I 0.866
SPI1 Felis catus ENSFCAG00000002531 I 0.866
ENSPCAG00000016572 Procavia capensis ENSPCAG00000016572 I 0.866
ENSPPYG00000003306 Pongo abelii ENSPPYG00000003306 I 0.866
ENSSTOG00000022735 Ictidomys tridecemlineatus ENSSTOG00000022735 I 0.866
SPI1 Equus caballus ENSECAG00000024457 I 0.866
SPI1 Pteropus vampyrus ENSPVAG00000007336 I 0.866
SPI1 Callithrix jacchus ENSCJAG00000020100 I 0.866
SPI1 Canis familiaris ENSCAFG00000008723 I 0.866
spi1 Xenopus tropicalis XB-GENE-1018247 I 0.866
SPI1 Bos taurus ENSBTAG00000021709 I 0.866
Myotis_brandtii_Mybpc3_10025524 Myotis brandtii Myotis_brandtii_Mybpc3_10025524 I 0.866
ENSP00000227163-D1 Bos grunniens ENSP00000227163-D1 I 0.866
SPI1 Tursiops truncatus ENSTTRG00000014153 I 0.866
ENSCSAG00000005757 Chlorocebus sabaeus ENSCSAG00000005757 I 0.866
ENSAMEG00000007488 Ailuropoda melanoleuca ENSAMEG00000007488 I 0.866
Spi1 Dipodomys ordii ENSDORG00000007758 I 0.866
Spi1 Rattus norvegicus ENSRNOG00000012172 I 0.866
SPI1 Loxodonta africana ENSLAFG00000004062 I 0.866
ENSNLEG00000014555 Nomascus leucogenys ENSNLEG00000014555 I 0.866
SPI1 Dasypus novemcinctus ENSDNOG00000041462 I 0.866
SPI1 Homo sapiens ENSG00000066336 D 0.866
Spi1 Mus musculus ENSMUSG00000002111 D 0.866
SPI1 Monodelphis domestica ENSMODG00000019909 I 0.866
ENSMPUG00000004125 Mustela putorius furo ENSMPUG00000004125 I 0.866
ENSOARG00000006553 Ovis aries ENSOARG00000006553 I 0.866
SPI1 Ornithorhynchus anatinus ENSOANG00000009414 I 0.866
ENSPANG00000004468 Papio anubis ENSPANG00000004468 I 0.866
SPI1 Otolemur garnettii ENSOGAG00000012435 I 0.866
SPI1 Gorilla gorilla ENSGGOG00000006485 I 0.866
L893_g22986 Steinernema glaseri L893_g22986 N 0.862
ELF3 Procavia capensis ENSPCAG00000012191 I 0.849
Aan_R012619 Calypte anna Aan_R012619 I 0.846
SPI1 Gallus gallus ENSGALG00000008127 I 0.846
ENSAPLG00000002423 Anas platyrhynchos ENSAPLG00000002423 I 0.846
Brh_R000822 Buceros rhinoceros Brh_R000822 I 0.846
Afo_R002289 Aptenodytes forsteri Afo_R002289 I 0.846
Gfo_R014179 Geospiza fortis Gfo_R014179 I 0.846
SPI1 Meleagris gallopavo ENSMGAG00000010682 I 0.846
Pvit_08680 Pogona vitticeps Pvit_08680 I 0.846
Tal_R006659 Tyto alba Tal_R006659 I 0.846
Ogr17892 Ophisaurus gracilis Ogr17892 I 0.846
SPI1 Taeniopygia guttata ENSTGUG00000010422 I 0.846
SPI1 Anolis carolinensis ENSACAG00000002490 I 0.846
Cmyd_10014952 Chelonia mydas Cmyd_10014952 I 0.845
ENSPSIG00000004344 Pelodiscus sinensis ENSPSIG00000004344 I 0.845
ENSSHAG00000017291 Sarcophilus harrisii ENSSHAG00000017291 I 0.844
SPI1 Cavia porcellus ENSCPOG00000022138 I 0.836
ENSSSCG00000024457 Sus scrofa ENSSSCG00000024457 I 0.830
ENSLOCG00000006249 Lepisosteus oculatus ENSLOCG00000006249 I 0.822
Alligator_sinensis_CCG017634.1 Alligator sinensis Alligator_sinensis_CCG017634.1 I 0.822
ENSFALG00000006392 Ficedula albicollis ENSFALG00000006392 I 0.822
ENSLACG00000018937 Latimeria chalumnae ENSLACG00000018937 I 0.821
ENSPFOG00000003818 Poecilia formosa ENSPFOG00000003818 I 0.818
ENSGMOG00000018771 Gadus morhua ENSGMOG00000018771 I 0.818
ENSPFOG00000001948 Poecilia formosa ENSPFOG00000001948 I 0.818
spi1b Oryzias latipes ENSORLG00000006090 I 0.818
spi1b Gasterosteus aculeatus ENSGACG00000015525 I 0.818
ENSONIG00000002940 Oreochromis niloticus ENSONIG00000002940 I 0.818
ENSXMAG00000018836 Xiphophorus maculatus ENSXMAG00000018836 I 0.818
spi1b Tetraodon nigroviridis ENSTNIG00000009407 I 0.818
spi1b Takifugu rubripes ENSTRUG00000017273 I 0.818
ENSTNIG00000007898 Tetraodon nigroviridis ENSTNIG00000007898 N 0.812
ETS2 Monodelphis domestica ENSMODG00000020979 I 0.802
ENSAMXG00000006005 Astyanax mexicanus ENSAMXG00000006005 I 0.792
ENSAMXG00000017734 Astyanax mexicanus ENSAMXG00000017734 I 0.790
ENSLOCG00000015193 Lepisosteus oculatus ENSLOCG00000015193 I 0.779
ENSLACG00000022621 Latimeria chalumnae ENSLACG00000022621 I 0.762
L898_g23769 Steinernema monticolum L898_g23769 N 0.761
D917_09895 Trichinella nativa D917_09895 I 0.757
ENSCING00000022310 Ciona intestinalis ENSCING00000022310 I 0.756
spi1a Danio rerio ENSDARG00000067797 I 0.752
TASK_0000713501 Taenia asiatica TASK_0000713501 N 0.740
SPIC Erinaceus europaeus ENSEEUG00000012461 I 0.736
SPER_0003658001 Spirometra erinaceieuropaei SPER_0003658001 N 0.729
SSLN_0001232601 Schistocephalus solidus SSLN_0001232601 N 0.729
ETV2 Homo sapiens ENSG00000105672 D 0.721
ENSXMAG00000006900 Xiphophorus maculatus ENSXMAG00000006900 I 0.719
ENSPFOG00000019637 Poecilia formosa ENSPFOG00000019637 I 0.719
spib Xenopus tropicalis XB-GENE-479615 I 0.718
ENSOANG00000022349 Ornithorhynchus anatinus ENSOANG00000022349 I 0.718
GABPA Ochotona princeps ENSOPRG00000009283 I 0.718
spib.L Xenopus laevis XB-GENE-865287 I 0.718
GABPA Microcebus murinus ENSMICG00000006341 I 0.718