FOXK2 (Homo sapiens)
Forkhead

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00250 (Forkhead) IPR001766 ENSG00000141568 T185775_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
FOXK2
M08118_2.00
Homo sapiens
NNRTAAACANN

NNTGTTTAYNN
ChIP-seq
Mathelier et al.(2014)
MA1103.1
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Foxk1
M00163_2.00
Mus musculus
RWMAACAA

TTGTTKWY
PBM
Badis et al.(2009)
Foxk1_2323
0.828 0.895
Foxk1
M03061_2.00
Mus musculus
CGGACACAATC

GATTGTGTCCG
SELEX
Jolma et al.(2013)
Foxk1_1
0.828 0.895
Foxk1
M03062_2.00
Mus musculus
RTAAACA

TGTTTAY
SELEX
Jolma et al.(2013)
Foxk1_2
0.828 0.895
Foxk1
M09113_2.00
Mus musculus
NNGDMAACAVV

BBTGTTKHCNN
Misc
Kulakovskiy et al.(2013)
FOXK1_MOUSE.H11MO.0.A
0.828 0.895
FOXK1
M01977_2.00
Homo sapiens
NNRWMMAYAN

NTRTKKWYNN
PBM
Weirauch et al.(2014)
pTH6108
0.828 0.884
FOXK1
M03025_2.00
Homo sapiens
CGGACACAAT

ATTGTGTCCG
SELEX
Jolma et al.(2013)
FOXK1_1
0.828 0.884
FOXK1
M04825_2.00
Homo sapiens
NDNRTMAAYAN

NTRTTKAYNHN
SELEX
Yin et al.(2017)
FOXK1_eDBD_HT-SELEX
0.828 0.884
FOXK1
M08120_2.00
Homo sapiens
NNNGTAAACANVNN

NNBNTGTTTACNNN
ChIP-seq
Mathelier et al.(2014)
MA0852.2
0.828 0.884
FOXK1
M09094_2.00
Homo sapiens
VNDRDAAACA

TGTTTHYHNB
Misc
Kulakovskiy et al.(2013)
FOXK1_HUMAN.H11MO.0.A
0.828 0.884
FOXK1
M04826_2.00
Homo sapiens
NWYRYAAWYAD

HTRWTTRYRWN
SELEX
Yin et al.(2017)
FOXK1_eDBD_Methyl-HT-SELEX
0.828 0.884
SPU_025010
M01988_2.00
Strongylocentrotus purpuratus
NNVNHHAYAN

NTRTDDNBNN
PBM
Weirauch et al.(2014)
pTH6641
0.817 0.872
FOXI1
M03026_2.00
Homo sapiens
GTAAACA

TGTTTAC
SELEX
Jolma et al.(2013)
FOXI1_1
0.728 0.547
FOXI1
M03027_2.00
Homo sapiens
RTGTKTACGGTAAACAA

TTGTTTACCGTAMACAY
SELEX
Jolma et al.(2013)
FOXI1_2
0.728 0.547
FOXI1
M04827_2.00
Homo sapiens
NNNNNRTMAACAN

NTGTTKAYNNNNN
SELEX
Yin et al.(2017)
FOXI1_eDBD_HT-SELEX
0.728 0.547
FOXI1
M04829_2.00
Homo sapiens
AAYGTAAACAMW

WKTGTTTACRTT
SELEX
Yin et al.(2017)
FOXI1_FL_HT-SELEX
0.728 0.547
FOXI1
M09095_2.00
Homo sapiens
RRCCAATCAVAD

HTBTGATTGGYY
Misc
Kulakovskiy et al.(2013)
FOXI1_HUMAN.H11MO.0.B
0.728 0.547
FOXI1
M10556_2.00
Homo sapiens
HAWAYAAAYAHVH

DBDTRTTTRTWTD
Transfac
Matys et al.(2006)
V$HFH3_01
0.728 0.547
FOXI1
M04828_2.00
Homo sapiens
NWWVHRTAAACAH

DTGTTTAYDBWWN
SELEX
Yin et al.(2017)
FOXI1_eDBD_Methyl-HT-SELEX
0.728 0.547
FOXI1
M04830_2.00
Homo sapiens
AAYRTAAACAAW

WTTGTTTAYRTT
SELEX
Yin et al.(2017)
FOXI1_FL_Methyl-HT-SELEX
0.728 0.547
Foxi1
M09109_2.00
Mus musculus
RRCCAATCAVAD

HTBTGATTGGYY
Misc
Kulakovskiy et al.(2013)
FOXI1_MOUSE.H11MO.0.B
0.728 0.535
FOXJ3
M03046_2.00
Homo sapiens
RTAAAVAA

TTBTTTAY
SELEX
Jolma et al.(2013)
FOXJ3_1
0.708 0.581
FOXJ3
M03047_2.00
Homo sapiens
GTAAACARTMAACA

TGTTKAYTGTTTAC
SELEX
Jolma et al.(2013)
FOXJ3_2
0.708 0.581
FOXJ3
M03048_2.00
Homo sapiens
GTAAACATAAACA

TGTTTATGTTTAC
SELEX
Jolma et al.(2013)
FOXJ3_3
0.708 0.581
FOXJ3
M02736_2.00
Homo sapiens
AAACAATAAACA

TGTTTATTGTTT
SELEX
Jolma et al.(2010)
FOXJ3_dimer
0.708 0.581
FOXJ3
M02737_2.00
Homo sapiens
RTAAACAW

WTGTTTAY
SELEX
Jolma et al.(2010)
FOXJ3_monomer
0.708 0.581
FOXJ3
M04859_2.00
Homo sapiens
DYGTMAACAH

DTGTTKACRH
SELEX
Yin et al.(2017)
FOXJ3_eDBD_HT-SELEX
0.708 0.581
FOXJ3
M09098_2.00
Homo sapiens
WAAMMATAAACAN

NTGTTTATKKTTW
Misc
Kulakovskiy et al.(2013)
FOXJ3_HUMAN.H11MO.0.A
0.708 0.581
FOXJ3
M04860_2.00
Homo sapiens
RYGTMAACAH

DTGTTKACRY
SELEX
Yin et al.(2017)
FOXJ3_eDBD_Methyl-HT-SELEX
0.708 0.581
SPU_007644
M01987_2.00
Strongylocentrotus purpuratus
NNHHAYDNN

NNHRTDDNN
PBM
Weirauch et al.(2014)
pTH6497
0.707 0.581
Foxj3
M00160_2.00
Mus musculus
NRTAAACAHN

NDTGTTTAYN
PBM
Badis et al.(2009)
Foxj3_0982
0.706 0.581
Foxj3
M01981_2.00
Mus musculus
VNHHAYANN

NNTRTDDNB
PBM
Weirauch et al.(2014)
pTH6591
0.706 0.581
Foxj3
M03055_2.00
Mus musculus
ACGGACACAAT

ATTGTGTCCGT
SELEX
Jolma et al.(2013)
Foxj3_1
0.706 0.581
Foxj3
M03056_2.00
Mus musculus
GTAAACARTMAACA

TGTTKAYTGTTTAC
SELEX
Jolma et al.(2013)
Foxj3_2
0.706 0.581
Foxj3
M03057_2.00
Mus musculus
RTAAACAW

WTGTTTAY
SELEX
Jolma et al.(2013)
Foxj3_3
0.706 0.581
Foxj3
M03058_2.00
Mus musculus
RTAAACAWAAACA

TGTTTWTGTTTAY
SELEX
Jolma et al.(2013)
Foxj3_4
0.706 0.581
Foxj3
M09102_2.00
Mus musculus
WAAMMATAAACAN

NTGTTTATKKTTW
Misc
Kulakovskiy et al.(2013)
FOXJ3_MOUSE.H11MO.0.A
0.706 0.581
FOXC1
M00257_2.00
Homo sapiens
NNNVHHAAYA

TRTTDDBNNN
PBM
Barrera et al.(2016)
FOXC1_REF
0.700 0.593
Foxc1
M01982_2.00
Mus musculus
HNNRHMAAYA

TRTTKDYNND
PBM
Weirauch et al.(2014)
pTH2673
0.700 0.593
FOXC1
M03013_2.00
Homo sapiens
AWRTAAAYAAAYA

TRTTTRTTTAYWT
SELEX
Jolma et al.(2013)
FOXC1_1
0.700 0.593
FOXC1
M03014_2.00
Homo sapiens
NRWMAATATTKWYN

NRWMAATATTKWYN
SELEX
Jolma et al.(2013)
FOXC1_2
0.700 0.593
FOXC1
M03015_2.00
Homo sapiens
WRWRTMAAYAW

WTRTTKAYWYW
SELEX
Jolma et al.(2013)
FOXC1_3
0.700 0.593
Foxc1
M03059_2.00
Mus musculus
RTAAAYAAACA

TGTTTRTTTAY
SELEX
Jolma et al.(2013)
Foxc1_1
0.700 0.593
Foxc1
M03060_2.00
Mus musculus
RTAAACA

TGTTTAY
SELEX
Jolma et al.(2013)
Foxc1_2
0.700 0.593
FOXC1
M09083_2.00
Homo sapiens
SBWAWRTAAACADHN

NDHTGTTTAYWTWVS
Misc
Kulakovskiy et al.(2013)
FOXC1_HUMAN.H11MO.0.C
0.700 0.593
Foxc1
M09111_2.00
Mus musculus
SBWAWRTAAACADHN

NDHTGTTTAYWTWVS
Misc
Kulakovskiy et al.(2013)
FOXC1_MOUSE.H11MO.0.C
0.700 0.593
FOXC1
M10525_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$FOXC1_Q4
0.700 0.593
FOXC1
M10526_2.00
Homo sapiens
TSTTTATTTACDBNVN

NBNVHGTAAATAAASA
Transfac
Matys et al.(2006)
V$FREAC3_01
0.700 0.593
FOXC1
M00253_2.00
Homo sapiens
NNHATAAWHAN

NTDWTTATDNN
PBM
Barrera et al.(2016)
FOXC1_F112S
0.700 0.593
FOXC1
M00255_2.00
Homo sapiens
NRTATATWHNNN

NNNDWATATAYN
PBM
Barrera et al.(2016)
FOXC1_L130F
0.700 0.581
FOXC1
M00256_2.00
Homo sapiens
NNNNWWTYAMAWN

NWTKTRAWWNNNN
PBM
Barrera et al.(2016)
FOXC1_P79L
0.700 0.581
FOXC1
M00258_2.00
Homo sapiens
NNNAMAAYANN

NNTRTTKTNNN
PBM
Barrera et al.(2016)
FOXC1_S131L
0.700 0.581
FOXC1
M00259_2.00
Homo sapiens
RTAAACAW

WTGTTTAY
PBM
Barrera et al.(2016)
FOXC1_S82T
0.700 0.581
Foxj2
M01980_2.00
Mus musculus
RTAAACAN

NTGTTTAY
PBM
Weirauch et al.(2014)
pTH6638
0.688 0.547
Foxj2
M00790_2.00
Mus musculus
VHMAAYANN

NNTRTTKDB
PBM
Weirauch et al.(2013)
pTH3043
0.684 0.558
FOXJ2
M03016_2.00
Homo sapiens
GTAAACARTMAACA

TGTTKAYTGTTTAC
SELEX
Jolma et al.(2013)
FOXJ2_1
0.684 0.558
FOXJ2
M03017_2.00
Homo sapiens
RTAAACAH

DTGTTTAY
SELEX
Jolma et al.(2013)
FOXJ2_2
0.684 0.558
FOXJ2
M03018_2.00
Homo sapiens
GTAAACAWMAACA

TGTTKWTGTTTAC
SELEX
Jolma et al.(2013)
FOXJ2_3
0.684 0.558
FOXJ2
M04809_2.00
Homo sapiens
NTRTTTACAAYANN

NNTRTTGTAAAYAN
SELEX
Yin et al.(2017)
FOXJ2_eDBD_HT-SELEX
0.684 0.558
FOXJ2
M09084_2.00
Homo sapiens
WARAYAAAYA

TRTTTRTYTW
Misc
Kulakovskiy et al.(2013)
FOXJ2_HUMAN.H11MO.0.C
0.684 0.558
Foxj2
M09100_2.00
Mus musculus
WARAYAAAYA

TRTTTRTYTW
Misc
Kulakovskiy et al.(2013)
FOXJ2_MOUSE.H11MO.0.C
0.684 0.558
FOXJ2
M10527_2.00
Homo sapiens
HHNHMRAYAAAYANHNND

HNNDNTRTTTRTYKDNDD
Transfac
Matys et al.(2006)
V$FOXJ2_01
0.684 0.558
FOXJ2
M10528_2.00
Homo sapiens
VYMAYAATATTTKN

NMAAATATTRTKRB
Transfac
Matys et al.(2006)
V$FOXJ2_02
0.684 0.558
FOXJ2
M04810_2.00
Homo sapiens
NTRTTTACAAYANN

NNTRTTGTAAAYAN
SELEX
Yin et al.(2017)
FOXJ2_eDBD_Methyl-HT-SELEX
0.684 0.558
FOXC1
M00254_2.00
Homo sapiens
RRTAAACANN

NNTGTTTAYY
PBM
Barrera et al.(2016)
FOXC1_I126M
0.675 0.581
FOXG1
M01978_2.00
Homo sapiens
RTAAACAH

DTGTTTAY
PBM
Weirauch et al.(2014)
pTH5501
0.672 0.605
Foxg1
M00791_2.00
Mus musculus
NNNNMHAYAN

NTRTDKNNNN
PBM
Weirauch et al.(2013)
pTH2846
0.672 0.605
FOXG1
M03032_2.00
Homo sapiens
RTAAACAATDGTAAACA

TGTTTACHATTGTTTAY
SELEX
Jolma et al.(2013)
FOXG1_1
0.672 0.605
FOXG1
M03033_2.00
Homo sapiens
RCGGACACAATR

YATTGTGTCCGY
SELEX
Jolma et al.(2013)
FOXG1_2
0.672 0.605
Foxg1
M03052_2.00
Mus musculus
ATAAACAAVTGTMAACA

TGTTKACABTTGTTTAT
SELEX
Jolma et al.(2013)
Foxg1_1
0.672 0.605
Foxg1
M03053_2.00
Mus musculus
MHGGACACAATC

GATTGTGTCCDK
SELEX
Jolma et al.(2013)
Foxg1_2
0.672 0.605
Foxg1
M03054_2.00
Mus musculus
GTAAACA

TGTTTAC
SELEX
Jolma et al.(2013)
Foxg1_3
0.672 0.605
FOXG1
M04839_2.00
Homo sapiens
NACRYMMACAH

DTGTKKRYGTN
SELEX
Yin et al.(2017)
FOXG1_eDBD_HT-SELEX
0.672 0.605
FOXG1
M04840_2.00
Homo sapiens
HRCGYMAACAH

DTGTTKRCGYD
SELEX
Yin et al.(2017)
FOXG1_eDBD_Methyl-HT-SELEX
0.672 0.605
foxg1a
M01985_2.00
Oryzias latipes
RTAAACAH

DTGTTTAY
PBM
Weirauch et al.(2014)
pTH6729
0.670 0.581
slp1
M01986_2.00
Drosophila melanogaster
NRTAAACANN

NNTGTTTAYN
PBM
Weirauch et al.(2014)
pTH6549
0.670 0.547
slp1
M03736_2.00
Drosophila melanogaster
WDYRTAAACAWW

WWTGTTTAYRHW
SELEX
Nitta et al.(2015)
slp1_1
0.670 0.547
slp1
M03737_2.00
Drosophila melanogaster
RTRTAAACAAAYADH

DHTRTTTGTTTAYAY
SELEX
Nitta et al.(2015)
slp1_2
0.670 0.547
slp1
M06474_2.00
Drosophila melanogaster
WRBVWAAACAH

DTGTTTWBVYW
B1H
Mathelier et al.(2014)
MA0458.1
0.670 0.547
slp1
M06195_2.00
Drosophila melanogaster
WRBVWAAACAH

DTGTTTWBVYW
B1H
Zhu et al.(2011)
slp1_NAR_FBgn0003430
0.670 0.547
slp1
M09669_2.00
Drosophila melanogaster
ATGTMAACAMAVV

BBTKTGTTKACAT
Misc
Kulakovskiy et al.(2009)
slp1
0.670 0.547
CBG14280
M01974_2.00
Caenorhabditis briggsae
RTAAACAN

NTGTTTAY
PBM
Weirauch et al.(2014)
pTH6734
0.669 0.558
Foxc2
M00796_2.00
Mus musculus
HNNRHMAAYA

TRTTKDYNND
PBM
Weirauch et al.(2013)
pTH3796
0.667 0.581
FOXC2
M03036_2.00
Homo sapiens
NRTMAATATTDWYN

NRWHAATATTKAYN
SELEX
Jolma et al.(2013)
FOXC2_1
0.667 0.581
FOXC2
M03037_2.00
Homo sapiens
RTAAAYAAACA

TGTTTRTTTAY
SELEX
Jolma et al.(2013)
FOXC2_2
0.667 0.581
FOXC2
M03038_2.00
Homo sapiens
WAHRTMAAYAWW

WWTRTTKAYDTW
SELEX
Jolma et al.(2013)
FOXC2_3
0.667 0.581
FOXC2
M04841_2.00
Homo sapiens
NHVNRYMAACAH

DTGTTKRYNBDN
SELEX
Yin et al.(2017)
FOXC2_eDBD_HT-SELEX_1
0.667 0.581
FOXC2
M04842_2.00
Homo sapiens
RHAMAYAAACAH

DTGTTTRTKTDY
SELEX
Yin et al.(2017)
FOXC2_eDBD_HT-SELEX_2
0.667 0.581
FOXC2
M10559_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$FKHL14_Q2
0.667 0.581
FOXC2
M04843_2.00
Homo sapiens
NHNNRYMAACAN

NTGTTKRYNNDN
SELEX
Yin et al.(2017)
FOXC2_eDBD_Methyl-HT-SELEX_1
0.667 0.581
FOXC2
M04844_2.00
Homo sapiens
VHMMAYAAACAN

NTGTTTRTKKDB
SELEX
Yin et al.(2017)
FOXC2_eDBD_Methyl-HT-SELEX_2
0.667 0.581
FOXP1
M00836_2.00
Homo sapiens
NRTMAACANN

NNTGTTKAYN
PBM
Gabut et al.(2011)
pEX0123
0.665 0.419
FOXP1
M00837_2.00
Homo sapiens
DGTAAACAA

TTGTTTACH
PBM
Gabut et al.(2011)
pEX0124
0.665 0.419
FOXP1
M01976_2.00
Homo sapiens
RTAAACAA

TTGTTTAY
PBM
Weirauch et al.(2014)
pTH5656
0.665 0.419
Foxp1
M00793_2.00
Mus musculus
NRTMAAYAN

NTRTTKAYN
PBM
Weirauch et al.(2013)
pTH3855
0.665 0.419
FOXP1
M04811_2.00
Homo sapiens
NTGTTTRYNRTNNNNNNBNAYRVWMAACAN

NTGTTKWBYRTNVNNNNNNAYNRYAAACAN
SELEX
Yin et al.(2017)
FOXP1_eDBD_HT-SELEX
0.665 0.419
FOXP1
M08115_2.00
Homo sapiens
NDGTAAACAVNN

NNBTGTTTACHN
ChIP-seq
Mathelier et al.(2014)
MA0481.2
0.665 0.419
FOXP1
M09086_2.00
Homo sapiens
RKAAACAVM

KBTGTTTMY
Misc
Kulakovskiy et al.(2013)
FOXP1_HUMAN.H11MO.0.A
0.665 0.419
FOXP1
M09541_2.00
Homo sapiens
NDGTAAACAVNN

NNBTGTTTACHN
Misc
Heinz et al.(2010)
H9-FOXP1_GSE31006
0.665 0.419
FOXP1
M10536_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$FOXP1_01
0.665 0.419
FOXP1
M04812_2.00
Homo sapiens
NTGTTTRYBRTNNNNNNBNAYRVWMAACAH

DTGTTKWBYRTNVNNNNNNAYVRYAAACAN
SELEX
Yin et al.(2017)
FOXP1_eDBD_Methyl-HT-SELEX
0.665 0.419
For this family, TFs with SR scores > 0.664 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000335677 Forkhead 258 347
ENSP00000432663 Forkhead 138 227
ENSP00000433167 Forkhead 69 158
ENSP00000436108 Forkhead 258 347
ENSP00000481132 Forkhead 254 343

Links

Other Forkhead family TFs
Other Homo sapiens TFs

1186 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
AALB009393 Anopheles albimanus AALB009393 I 0.000
AARA001656 Anopheles arabiensis AARA001656 I 0.000
AATE021108 Anopheles atroparvus AATE021108 I 0.000
ACHR007539 Anopheles christyi ACHR007539 I 0.000
ACOM033756 Anopheles coluzzii ACOM033756 I 0.000
ACUA025676 Anopheles culicifacies ACUA025676 I 0.000
ADIR010044 Anopheles dirus ADIR010044 I 0.000
AEPI006953 Anopheles epiroticus AEPI006953 I 0.000
AFAF007581 Anopheles farauti AFAF007581 I 0.000
AFUN009221 Anopheles funestus AFUN009221 I 0.000
AMAM006284 Anopheles maculatus AMAM006284 I 0.000
AMEC003386 Anopheles melas AMEC003386 I 0.000
AMEC015151 Anopheles melas AMEC015151 I 0.000
AMEM001654 Anopheles merus AMEM001654 I 0.000
AMIN002289 Anopheles minimus AMIN002289 I 0.000
AQUA006380 Anopheles quadriannulatus AQUA006380 I 0.000
ASIS019148 Anopheles sinensis ASIS019148 I 0.000
BGIBMGA013198 Bombyx mori BGIBMGA013198 D 0.000
KGM_08612 Danaus plexippus KGM_08612 I 0.000
DAPPUDRAFT_43067 Daphnia pulex DAPPUDRAFT_43067 I 0.000
YQE_05964 Dendroctonus ponderosae YQE_05964 I 0.000
GI15686 Drosophila mojavensis FBgn0138435 I 0.000
HMEL014166 Heliconius melpomene HMEL014166 I 0.000
LCUP013174 Lucilia cuprina LCUP013174 I 0.000
PHUM322020 Pediculus humanus PHUM322020 I 0.000
PPAI008545 Phlebotomus papatasi PPAI008545 I 0.000
SINV23626 Solenopsis invicta SINV23626 I 0.000