TF Information

FHL1 *(Saccharomyces cerevisiae)* Forkhead
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00250 (Forkhead)	IPR001766	YPR104C	T188840_2.00	Ensembl (2018-Dec-8)	Link out
NCBI Gene Info: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; transcription coactivator binding activity; and transcription corepressor binding activity. Involved in negative regulation of ribosomal protein gene transcription by RNA polymerase II and positive regulation of ribosomal protein gene transcription by RNA polymerase II. Located in chromatin and nucleolus. Orthologous to human FOXN4 (forkhead box N4) and FOXO4 (forkhead box O4). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
FHL1 M00046_2.00	Saccharomyces cerevisiae	NGACGCAM	KTGCGTCN	PBM Badis et al.(2008) FHL1_2086	(Direct)	(Direct)
FHL1 M01543_2.00	Saccharomyces cerevisiae	NVDCGCRNN	NNYGCGHBN	PBM Zhu et al.(2009) Fhl1	(Direct)	(Direct)
FHL1 M07475_2.00	Saccharomyces cerevisiae	GACGCAVN	NBTGCGTC	PBM, CSA and or DIP-chip Mathelier et al.(2014) MA0295.1	(Direct)	(Direct)
FHL1 M08557_2.00	Saccharomyces cerevisiae	NNNDDNGACGCAMWNNNNDN	NHNNNNWKTGCGTCNHHNNN	Misc DeBoer et al.(2011) YPR104C_808	(Direct)	(Direct)
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
KLLA0_F08206g M01015_2.00	Kluyveromyces lactis	NNVRYKCRNN	NNYGMRYBNN	PBM Nakagawa et al.(2013) KLLA0F08206p	0.701	0.890
AGOS_AEL327W M01004_2.00	Ashbya gossypii	NNVRCKCRNN	NNYGMGYBNN	PBM Nakagawa et al.(2013) AEL327Wp	0.692	0.902
For this family, TFs with SR scores > 0.664* will likely have a similar motif*

Experimental Constructs

Motif ID	Domain	From	To	Sequence
M00046_2.00	Forkhead	51	137	KPTVSYSAMLTTCIRKYSTAKGMSLSEIYAGIRELFPYYKYCPDGWQSSVRHNLSLNKSFRKVSKEGKGWLWGLDEEYIAERERQKK
M01543_2.00	Forkhead	461	547	KPTVSYSAMLTTCIRKYSTAKGMSLSEIYAGIRELFPYYKYCPDGWQSSVRHNLSLNKSFRKVSKEGKGWLWGLDEEYIAERERQKK

DNA Binding Domains

Protein ID	Domain	From	To	Sequence
YPR104C	Forkhead	461	547	KPTVSYSAMLTTCIRKYSTAKGMSLSEIYAGIRELFPYYKYCPDGWQSSVRHNLSLNKSFRKVSKEGKGWLWGLDEEYIAERERQKK

Links
Other Forkhead family TFs
Other *Saccharomyces cerevisiae* TFs

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32 Related TFs

Name	Species	Gene ID	Motif Evidence	SR Score	Action