GCM2 (Homo sapiens)
GCM

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF03615 (GCM) IPR003902 ENSG00000124827 T197996_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
GCM2
M03067_2.00
Homo sapiens
NATGCGGGYD

HRCCCGCATN
SELEX
Jolma et al.(2013)
GCM2_1
(Direct) (Direct)
GCM2
M04881_2.00
Homo sapiens
RTGCGGGYN

NRCCCGCAY
SELEX
Yin et al.(2017)
GCM2_FL_HT-SELEX
(Direct) (Direct)
GCM2
M04882_2.00
Homo sapiens
ATRHKGGYN

NRCCMDYAT
SELEX
Yin et al.(2017)
GCM2_FL_Methyl-HT-SELEX
(Direct) (Direct)
GCM2
M10602_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GCMB_Q2
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
GCM2
M02023_2.00
Taeniopygia guttata
NRTRHKGGYN

NRCCMDYAYN
PBM
Weirauch et al.(2014)
pTH9341
0.870 0.870
ENSTRUG00000003586
M02025_2.00
Takifugu rubripes
NRTRNGGGYN

NRCCCNYAYN
PBM
Weirauch et al.(2014)
pTH9357
0.833 0.833
gcm2
M02024_2.00
Tetraodon nigroviridis
ATRCGGGY

RCCCGYAT
PBM
Weirauch et al.(2014)
pTH9386
0.826 0.826
Gcm1
M00168_2.00
Mus musculus
NVTRVGGGY

RCCCBYABN
PBM
Badis et al.(2009)
Gcm1_3732
0.710 0.710
Gcm1
M02022_2.00
Rattus norvegicus
NNRTRVGGGY

RCCCBYAYNN
PBM
Weirauch et al.(2014)
pTH9283
0.710 0.710
XP_004449939.1
M02027_2.00
Dasypus novemcinctus
RTRSGGGY

RCCCSYAY
PBM
Weirauch et al.(2014)
pTH9259
0.703 0.703
GCM1
M02020_2.00
Homo sapiens
NVTVNGGGN

NCCCNBABN
PBM
Weirauch et al.(2014)
pTH7965
0.696 0.696
GCM1
M02021_2.00
Meleagris gallopavo
VTVNKGGYNN

NNRCCMNBAB
PBM
Weirauch et al.(2014)
pTH8653
0.696 0.696
GCM1
M03068_2.00
Homo sapiens
BATGCGGGTR

YACCCGCATV
SELEX
Jolma et al.(2013)
GCM1_1
0.696 0.696
GCM1
M03069_2.00
Homo sapiens
RTRYKGGYRCCMGYAN

NTRCKGGYRCCMRYAY
SELEX
Jolma et al.(2013)
GCM1_2
0.696 0.696
GCM1
M03070_2.00
Homo sapiens
BATGCGGGTRS

SYACCCGCATV
SELEX
Jolma et al.(2013)
GCM1_3
0.696 0.696
GCM1
M04883_2.00
Homo sapiens
RTGSGGGBV

BVCCCSCAY
SELEX
Yin et al.(2017)
GCM1_eDBD_HT-SELEX
0.696 0.696
GCM1
M05868_2.00
Homo sapiens
ATGCGGGYV

BRCCCGCAT
SMiLE-seq
Isakova et al.(2017)
GCM1
0.696 0.696
GCM1
M10603_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GCMA_Q4
0.696 0.696
GCM1
M10604_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GCM_Q2
0.696 0.696
GCM1
M04884_2.00
Homo sapiens
ATRNKGGYV

BRCCMNYAT
SELEX
Yin et al.(2017)
GCM1_eDBD_Methyl-HT-SELEX
0.696 0.696
gcm2
M02026_2.00
Drosophila melanogaster
ATGCGGGY

RCCCGCAT
PBM
Weirauch et al.(2014)
pTH8361
0.688 0.688
gcm2
M03767_2.00
Drosophila melanogaster
NATGCGGGYNNNRCCCGCATN

NATGCGGGYNNNRCCCGCATN
SELEX
Nitta et al.(2015)
gcm2_1
0.688 0.688
gcm2
M03768_2.00
Drosophila melanogaster
BATGCKGGTACCMGCATV

BATGCKGGTACCMGCATV
SELEX
Nitta et al.(2015)
gcm2_2
0.688 0.688
gcm
M03764_2.00
Drosophila melanogaster
HATGCGGGYVVBRCCCGCATV

BATGCGGGYVBBRCCCGCATD
SELEX
Nitta et al.(2015)
gcm_1
0.659 0.659
gcm
M03765_2.00
Drosophila melanogaster
VATGCKGGYRCCMGCATV

BATGCKGGYRCCMGCATB
SELEX
Nitta et al.(2015)
gcm_2
0.659 0.659
gcm
M03766_2.00
Drosophila melanogaster
YATGCGGGTACCAGCATV

BATGCTGGTACCCGCATR
SELEX
Nitta et al.(2015)
gcm_3
0.659 0.659
gcm
M10605_2.00
Drosophila melanogaster
NDNATGCGGGYNB

VNRCCCGCATNHN
Transfac
Matys et al.(2006)
I$GCM_01
0.659 0.659
For this family, TFs with SR scores > 0.607 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000368805 GCM 35 172

Links

Other GCM family TFs
Other Homo sapiens TFs

225 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
GCM2 Gorilla gorilla ENSGGOG00000023360 I 1.000
ENSPPYG00000016228 Pongo abelii ENSPPYG00000016228 I 0.993
ENSCSAG00000007467 Chlorocebus sabaeus ENSCSAG00000007467 I 0.986
GCM2 Pan troglodytes ENSPTRG00000017724 I 0.986
GCM2 Macaca mulatta ENSMMUG00000007719 I 0.986
ENSP00000368805 Macaca fascicularis ENSP00000368805 I 0.986
ENSPANG00000026314 Papio anubis ENSPANG00000026314 I 0.978
ENSNLEG00000000645 Nomascus leucogenys ENSNLEG00000000645 I 0.978
GCM2 Callithrix jacchus ENSCJAG00000019182 I 0.971
GCM2 Otolemur garnettii ENSOGAG00000012176 I 0.964
ENSP00000368805-D1 Bos grunniens ENSP00000368805-D1 I 0.957
GCM2 Felis catus ENSFCAG00000001608 I 0.957
ENSMPUG00000000633 Mustela putorius furo ENSMPUG00000000633 I 0.957
GCM2 Canis familiaris ENSCAFG00000009747 I 0.957
GCM2 Bos taurus ENSBTAG00000018787 I 0.957
GCM2 Cavia porcellus ENSCPOG00000011254 I 0.949
GCM2 Choloepus hoffmanni ENSCHOG00000011562 I 0.949
ENSMICG00000004238 Microcebus murinus ENSMICG00000004238 I 0.949
GCM2 Myotis lucifugus ENSMLUG00000004637 I 0.949
ENSAMEG00000002669 Ailuropoda melanoleuca ENSAMEG00000002669 I 0.949
GCM2 Tupaia belangeri ENSTBEG00000006181 I 0.949
GCM2 Equus caballus ENSECAG00000017632 I 0.949
GCM2 Oryctolagus cuniculus ENSOCUG00000017698 I 0.942
ENSTSYG00000006813 Tarsius syrichta ENSTSYG00000006813 I 0.942
Gcm2 Rattus norvegicus ENSRNOG00000015008 I 0.935
GCM2 Dasypus novemcinctus ENSDNOG00000003701 I 0.935
ENSOARG00000015521 Ovis aries ENSOARG00000015521 I 0.935
GCM2 Loxodonta africana ENSLAFG00000007475 I 0.928
GCM2 Ochotona princeps ENSOPRG00000012641 I 0.928
ENSSTOG00000009563 Ictidomys tridecemlineatus ENSSTOG00000009563 I 0.928
GCM2 Vicugna pacos ENSVPAG00000003006 I 0.928
GCM2 Tursiops truncatus ENSTTRG00000003674 I 0.928
Gcm2 Mus musculus ENSMUSG00000021362 I 0.928
GCM2 Monodelphis domestica ENSMODG00000010371 I 0.906
GCM2 Pteropus vampyrus ENSPVAG00000004876 I 0.899
GCM2 Echinops telfairi ENSETEG00000012473 I 0.898
ENSPSIG00000004698 Pelodiscus sinensis ENSPSIG00000004698 I 0.891
ENSSHAG00000010590 Sarcophilus harrisii ENSSHAG00000010590 I 0.891
Cmyd_10006831 Chelonia mydas Cmyd_10006831 I 0.884
GCM2 Procavia capensis ENSPCAG00000011887 I 0.884
Aan_R001550 Calypte anna Aan_R001550 I 0.877
GCM2 Taeniopygia guttata ENSTGUG00000005756 D 0.870
Brh_R007088 Buceros rhinoceros Brh_R007088 I 0.870
Gfo_R006501 Geospiza fortis Gfo_R006501 I 0.870
Afo_R013226 Aptenodytes forsteri Afo_R013226 I 0.870
GCM2 Ornithorhynchus anatinus ENSOANG00000007191 I 0.862
ENSAPLG00000002817 Anas platyrhynchos ENSAPLG00000002817 I 0.862
ENSFALG00000013344 Ficedula albicollis ENSFALG00000013344 I 0.862
ENSONIG00000009885 Oreochromis niloticus ENSONIG00000009885 I 0.855
GCM2 Gallus gallus ENSGALG00000012768 I 0.855
gcm2 Danio rerio ENSDARG00000045413 I 0.855
ENSPFOG00000008781 Poecilia formosa ENSPFOG00000008781 I 0.848
GCM2 Meleagris gallopavo ENSMGAG00000003533 I 0.848
Alligator_sinensis_CCG008975.1 Alligator sinensis Alligator_sinensis_CCG008975.1 I 0.848
Pvit_11235 Pogona vitticeps Pvit_11235 I 0.841
ENSAMXG00000006073 Astyanax mexicanus ENSAMXG00000006073 I 0.841
ENSXMAG00000002726 Xiphophorus maculatus ENSXMAG00000002726 I 0.841
ENSLACG00000009363 Latimeria chalumnae ENSLACG00000009363 I 0.841
gcm2 Xenopus tropicalis XB-GENE-492156 I 0.841
gcm2.S Xenopus laevis XB-GENE-866131 I 0.833
GCM2 Anolis carolinensis ENSACAG00000008677 I 0.833
gcm2 Gasterosteus aculeatus ENSGACG00000001157 I 0.833
ENSTRUG00000003586 Takifugu rubripes ENSTRUG00000003586 D 0.833
gcm2 Oryzias latipes ENSORLG00000019715 I 0.826
gcm2 Tetraodon nigroviridis ENSTNIG00000005042 D 0.826
ENSLOCG00000013145 Lepisosteus oculatus ENSLOCG00000013145 I 0.819
ENSGMOG00000012709 Gadus morhua ENSGMOG00000012709 I 0.812
ENSPMAG00000009211 Petromyzon marinus ENSPMAG00000009211 I 0.754
Pvit_03812 Pogona vitticeps Pvit_03812 I 0.725
ENSPSIG00000013518 Pelodiscus sinensis ENSPSIG00000013518 I 0.717
ENSTRUG00000001670 Takifugu rubripes ENSTRUG00000001670 I 0.717
Ogr12931 Ophisaurus gracilis Ogr12931 I 0.717
Gcm1 Rattus norvegicus ENSRNOG00000007932 D 0.710
ENSCPOG00000006856 Cavia porcellus ENSCPOG00000006856 I 0.710
Gcm1 Mus musculus ENSMUSG00000023333 D 0.710
ENSMEUG00000004103 Macropus eugenii ENSMEUG00000004103 I 0.710
GCM1 Monodelphis domestica ENSMODG00000018803 I 0.710
GCM1 Oryctolagus cuniculus ENSOCUG00000009246 I 0.710
Afo_R000272 Aptenodytes forsteri Afo_R000272 I 0.703
XP_004449939.1 Dasypus novemcinctus XP_004449939.1 D 0.703
ENSSHAG00000015905 Sarcophilus harrisii ENSSHAG00000015905 I 0.703
GCM1 Dasypus novemcinctus ENSDNOG00000016682 I 0.703
CGI_10019940 Crassostrea gigas CGI_10019940 I 0.703
ENSLACG00000003372 Latimeria chalumnae ENSLACG00000003372 I 0.703
MCINX011946 Melitaea cinxia MCINX011946 I 0.696
ENSSSCG00000002630 Sus scrofa ENSSSCG00000002630 I 0.696
HMEL005671 Heliconius melpomene HMEL005671 I 0.696
GCM1 Pteropus vampyrus ENSPVAG00000013341 I 0.696
GCM1 Bos taurus ENSBTAG00000008148 I 0.696
ENSAPLG00000004160 Anas platyrhynchos ENSAPLG00000004160 I 0.696
YQE_03062 Dendroctonus ponderosae YQE_03062 I 0.696
ENSTGUG00000012867 Taeniopygia guttata ENSTGUG00000012867 I 0.696
GCM1 Callithrix jacchus ENSCJAG00000011189 I 0.696
ENSTSYG00000000507 Tarsius syrichta ENSTSYG00000000507 I 0.696
Aan_R001196 Calypte anna Aan_R001196 I 0.696
ENSOARG00000015312 Ovis aries ENSOARG00000015312 I 0.696
GCM1 Gallus gallus ENSGALG00000016316 I 0.696
GCM1 Gorilla gorilla ENSGGOG00000006527 I 0.696
GCM1 Pan troglodytes ENSPTRG00000018288 I 0.696
GCM1 Homo sapiens ENSG00000137270 D 0.696
Tal_R009935 Tyto alba Tal_R009935 I 0.696
ENSCSAG00000013148 Chlorocebus sabaeus ENSCSAG00000013148 I 0.696
GCM1 Equus caballus ENSECAG00000014228 I 0.696
ENSFALG00000001854 Ficedula albicollis ENSFALG00000001854 I 0.696
Gfo_R013721 Geospiza fortis Gfo_R013721 I 0.696
GCM1 Meleagris gallopavo ENSMGAG00000013927 D 0.696
Brh_R000788 Buceros rhinoceros Brh_R000788 I 0.696
ENSNLEG00000003544 Nomascus leucogenys ENSNLEG00000003544 I 0.696
ENSBTAP00000010709-D1 Bos grunniens ENSBTAP00000010709-D1 I 0.696
GCM1 Macaca mulatta ENSMMUG00000022083 I 0.696
ENSP00000259803 Macaca fascicularis ENSP00000259803 I 0.696
ENSPPYG00000016719 Pongo abelii ENSPPYG00000016719 I 0.696
BGIBMGA006182 Bombyx mori BGIBMGA006182 I 0.696
TC014730 Tribolium castaneum TC014730 I 0.693
AALB008013 Anopheles albimanus AALB008013 I 0.688
GCM1 Canis familiaris ENSCAFG00000002273 I 0.688
GF22779 Drosophila ananassae FBgn0099773 I 0.688
gcm1.S Xenopus laevis XB-GENE-6252686 I 0.688
AAEL000623 Aedes aegypti AAEL000623 I 0.688
SINV21711 Solenopsis invicta SINV21711 I 0.688
GG10041 Drosophila erecta FBgn0102353 I 0.688
GCM1 Loxodonta africana ENSLAFG00000012093 I 0.688
GCM1 Felis catus ENSFCAG00000009490 I 0.688
ENSMPUG00000008870 Mustela putorius furo ENSMPUG00000008870 I 0.688
GCM1 Otolemur garnettii ENSOGAG00000007879 I 0.688
ENSSTOG00000022342 Ictidomys tridecemlineatus ENSSTOG00000022342 I 0.688
ENSAMEG00000005755 Ailuropoda melanoleuca ENSAMEG00000005755 I 0.688
Gcm1 Dipodomys ordii ENSDORG00000003627 I 0.688
gcm2 Drosophila melanogaster FBgn0019809 D 0.688
KGM_05743 Danaus plexippus KGM_05743 I 0.686
ASTEI01672 Anopheles stephensi ASTEI01672 I 0.681
AGAP007783 Anopheles gambiae AGAP007783 I 0.681
AQUA003642 Anopheles quadriannulatus AQUA003642 I 0.681
GCM1 Myotis lucifugus ENSMLUG00000002762 I 0.681
ENSLOCG00000016883 Lepisosteus oculatus ENSLOCG00000016883 I 0.681
AFUN009837 Anopheles funestus AFUN009837 I 0.681
AMAM003661 Anopheles maculatus AMAM003661 I 0.681
AMIN006368 Anopheles minimus AMIN006368 I 0.681
ADIR000711 Anopheles dirus ADIR000711 I 0.681
Myotis_brandtii_Gcm1_10005135 Myotis brandtii Myotis_brandtii_Gcm1_10005135 I 0.681
ENSMICG00000002274 Microcebus murinus ENSMICG00000002274 I 0.681
ACHR001414 Anopheles christyi ACHR001414 I 0.679
AEPI007160 Anopheles epiroticus AEPI007160 I 0.679
LDEC012509 Leptinotarsa decemlineata LDEC012509 I 0.679
ENSSTOG00000014763 Ictidomys tridecemlineatus ENSSTOG00000014763 I 0.675
Tal_R009965 Tyto alba Tal_R009965 I 0.675
Cflo_04549--XP_393815.2_APIME Camponotus floridanus Cflo_04549--XP_393815.2_APIME I 0.674
GL18919 Drosophila persimilis FBgn0156520 I 0.674
AARA011980 Anopheles arabiensis AARA011980 I 0.674
AFAF005680 Anopheles farauti AFAF005680 I 0.674
LCUP008083 Lucilia cuprina LCUP008083 I 0.674
GA17734 Drosophila pseudoobscura FBgn0077744 I 0.674
MDOA003644 Musca domestica MDOA003644 I 0.674
GJ18313 Drosophila virilis FBgn0205472 I 0.674
GCM1 Tursiops truncatus ENSTTRG00000015250 I 0.674
PHUM436840 Pediculus humanus PHUM436840 I 0.674
MDOA004732 Musca domestica MDOA004732 I 0.674
GI11073 Drosophila mojavensis FBgn0133835 I 0.671
GM17569 Drosophila sechellia FBgn0172477 I 0.671
ACUA009622 Anopheles culicifacies ACUA009622 I 0.671
Ocbimv22027544m.g Octopus bimaculoides Ocbimv22027544m.g I 0.671
GE18856 Drosophila yakuba FBgn0236239 I 0.671
ADAC002327 Anopheles darlingi ADAC002327 I 0.671
GB45031 Apis mellifera GB45031 I 0.671
ACEP23384 Atta cephalotes ACEP23384 I 0.671
AMAM005757 Anopheles maculatus AMAM005757 I 0.670
GCM1 Vicugna pacos ENSVPAG00000006379 I 0.667
ACYPI34548 Acyrthosiphon pisum ACYPI34548 I 0.667
tetur09g06060 Tetranychus urticae tetur09g06060 I 0.664
Hsal_09608--XP_393815.2_APIME Harpegnathos saltator Hsal_09608--XP_393815.2_APIME I 0.664
ASIS002985 Anopheles sinensis ASIS002985 I 0.664
AATE008476 Anopheles atroparvus AATE008476 I 0.664
GM12386 Drosophila sechellia FBgn0167323 I 0.659
gcm Drosophila melanogaster FBgn0014179 D 0.659
GK23867 Drosophila willistoni FBgn0225829 I 0.659
L798_07938 Zootermopsis nevadensis L798_07938 I 0.659
CPIJ006640 Culex quinquefasciatus CPIJ006640 I 0.657
GF21907 Drosophila ananassae FBgn0098907 I 0.657
PPAI003635 Phlebotomus papatasi PPAI003635 I 0.657
fgenesh2_pg.scaffold_122000051 Branchiostoma floridae fgenesh2_pg.scaffold_122000051 I 0.657
CpipJ_CPIJ006640 Culex pipiens CpipJ_CPIJ006640 I 0.657
GH10675 Drosophila grimshawi FBgn0118156 I 0.657
ACOM031025 Anopheles coluzzii ACOM031025 I 0.655
AMEM005966 Anopheles merus AMEM005966 I 0.655
NV17454 Nasonia vitripennis NV17454 I 0.652
GJ17916 Drosophila virilis FBgn0205084 I 0.652
AALB008012 Anopheles albimanus AALB008012 I 0.652
ISCW022914 Ixodes scapularis ISCW022914 I 0.652
GI17574 Drosophila mojavensis FBgn0140318 I 0.652
CLEC013329 Cimex lectularius CLEC013329 I 0.650
AMEC020313 Anopheles melas AMEC020313 I 0.650
RPRC001299 Rhodnius prolixus RPRC001299 I 0.650
Sakowv30018670m.g Saccoglossus kowalevskii Sakowv30018670m.g I 0.645
GK23810 Drosophila willistoni FBgn0225772 I 0.645
DAPPUDRAFT_26189 Daphnia pulex DAPPUDRAFT_26189 I 0.645
GG24019 Drosophila erecta FBgn0116158 I 0.643
GA11505 Drosophila pseudoobscura FBgn0071556 I 0.643
GE10457 Drosophila yakuba FBgn0228318 I 0.643
GL19218 Drosophila persimilis FBgn0156817 I 0.643
GH11056 Drosophila grimshawi FBgn0118537 I 0.643
LotgiG112320 Lottia gigantea LotgiG112320 I 0.630
AMEM008520 Anopheles merus AMEM008520 I 0.630
AQUA003641 Anopheles quadriannulatus AQUA003641 I 0.630
ASTEI01673 Anopheles stephensi ASTEI01673 I 0.630
AARA011979 Anopheles arabiensis AARA011979 I 0.630
AGAP007782 Anopheles gambiae AGAP007782 I 0.630
AFAF000663 Anopheles farauti AFAF000663 I 0.630
ACOM031032 Anopheles coluzzii ACOM031032 I 0.630
AEPI007161 Anopheles epiroticus AEPI007161 I 0.630
GD22349 Drosophila simulans FBgn0193756 I 0.629
ASIS021139 Anopheles sinensis ASIS021139 I 0.629
ADIR000710 Anopheles dirus ADIR000710 I 0.621
AAEL000631 Aedes aegypti AAEL000631 I 0.621
AATE020589 Anopheles atroparvus AATE020589 I 0.621
ACHR004082 Anopheles christyi ACHR004082 I 0.621
AMIN006367 Anopheles minimus AMIN006367 I 0.621
AFUN009836 Anopheles funestus AFUN009836 I 0.621
ACUA018162 Anopheles culicifacies ACUA018162 I 0.621
HelroG145480 Helobdella robusta HelroG145480 I 0.621
ENSETEG00000005181 Echinops telfairi ENSETEG00000005181 I 0.616
CapteG133139 Capitella teleta CapteG133139 I 0.616
CpipJ_CPIJ006639 Culex pipiens CpipJ_CPIJ006639 I 0.614
CPIJ006639 Culex quinquefasciatus CPIJ006639 I 0.614
Alligator_sinensis_CCG000160.1 Alligator sinensis Alligator_sinensis_CCG000160.1 I 0.609
ENSACAG00000008561 Anolis carolinensis ENSACAG00000008561 I 0.609