CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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GCM2
(
Homo sapiens
)
GCM
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF03615 (GCM)
IPR003902
ENSG00000124827
T197996_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism. [provided by RefSeq, Jul 2008]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
GCM2
M03067_2.00
Homo sapiens
NATGCGGGYD
HRCCCGCATN
SELEX
Jolma et al.(2013)
GCM2_1
(Direct)
(Direct)
GCM2
M04881_2.00
Homo sapiens
RTGCGGGYN
NRCCCGCAY
SELEX
Yin et al.(2017)
GCM2_FL_HT-SELEX
(Direct)
(Direct)
GCM2
M04882_2.00
Homo sapiens
ATRHKGGYN
NRCCMDYAT
SELEX
Yin et al.(2017)
GCM2_FL_Methyl-HT-SELEX
(Direct)
(Direct)
GCM2
M10602_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GCMB_Q2
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
GCM2
M02023_2.00
Taeniopygia guttata
NRTRHKGGYN
NRCCMDYAYN
PBM
Weirauch et al.(2014)
pTH9341
0.870
0.870
ENSTRUG00000003586
M02025_2.00
Takifugu rubripes
NRTRNGGGYN
NRCCCNYAYN
PBM
Weirauch et al.(2014)
pTH9357
0.833
0.833
gcm2
M02024_2.00
Tetraodon nigroviridis
ATRCGGGY
RCCCGYAT
PBM
Weirauch et al.(2014)
pTH9386
0.826
0.826
Gcm1
M00168_2.00
Mus musculus
NVTRVGGGY
RCCCBYABN
PBM
Badis et al.(2009)
Gcm1_3732
0.710
0.710
Gcm1
M02022_2.00
Rattus norvegicus
NNRTRVGGGY
RCCCBYAYNN
PBM
Weirauch et al.(2014)
pTH9283
0.710
0.710
XP_004449939.1
M02027_2.00
Dasypus novemcinctus
RTRSGGGY
RCCCSYAY
PBM
Weirauch et al.(2014)
pTH9259
0.703
0.703
GCM1
M02020_2.00
Homo sapiens
NVTVNGGGN
NCCCNBABN
PBM
Weirauch et al.(2014)
pTH7965
0.696
0.696
GCM1
M02021_2.00
Meleagris gallopavo
VTVNKGGYNN
NNRCCMNBAB
PBM
Weirauch et al.(2014)
pTH8653
0.696
0.696
GCM1
M03068_2.00
Homo sapiens
BATGCGGGTR
YACCCGCATV
SELEX
Jolma et al.(2013)
GCM1_1
0.696
0.696
GCM1
M03069_2.00
Homo sapiens
RTRYKGGYRCCMGYAN
NTRCKGGYRCCMRYAY
SELEX
Jolma et al.(2013)
GCM1_2
0.696
0.696
GCM1
M03070_2.00
Homo sapiens
BATGCGGGTRS
SYACCCGCATV
SELEX
Jolma et al.(2013)
GCM1_3
0.696
0.696
GCM1
M04883_2.00
Homo sapiens
RTGSGGGBV
BVCCCSCAY
SELEX
Yin et al.(2017)
GCM1_eDBD_HT-SELEX
0.696
0.696
GCM1
M05868_2.00
Homo sapiens
ATGCGGGYV
BRCCCGCAT
SMiLE-seq
Isakova et al.(2017)
GCM1
0.696
0.696
GCM1
M10603_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GCMA_Q4
0.696
0.696
GCM1
M10604_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GCM_Q2
0.696
0.696
GCM1
M04884_2.00
Homo sapiens
ATRNKGGYV
BRCCMNYAT
SELEX
Yin et al.(2017)
GCM1_eDBD_Methyl-HT-SELEX
0.696
0.696
gcm2
M02026_2.00
Drosophila melanogaster
ATGCGGGY
RCCCGCAT
PBM
Weirauch et al.(2014)
pTH8361
0.688
0.688
gcm2
M03767_2.00
Drosophila melanogaster
NATGCGGGYNNNRCCCGCATN
NATGCGGGYNNNRCCCGCATN
SELEX
Nitta et al.(2015)
gcm2_1
0.688
0.688
gcm2
M03768_2.00
Drosophila melanogaster
BATGCKGGTACCMGCATV
BATGCKGGTACCMGCATV
SELEX
Nitta et al.(2015)
gcm2_2
0.688
0.688
gcm
M03764_2.00
Drosophila melanogaster
HATGCGGGYVVBRCCCGCATV
BATGCGGGYVBBRCCCGCATD
SELEX
Nitta et al.(2015)
gcm_1
0.659
0.659
gcm
M03765_2.00
Drosophila melanogaster
VATGCKGGYRCCMGCATV
BATGCKGGYRCCMGCATB
SELEX
Nitta et al.(2015)
gcm_2
0.659
0.659
gcm
M03766_2.00
Drosophila melanogaster
YATGCGGGTACCAGCATV
BATGCTGGTACCCGCATR
SELEX
Nitta et al.(2015)
gcm_3
0.659
0.659
gcm
M10605_2.00
Drosophila melanogaster
NDNATGCGGGYNB
VNRCCCGCATNHN
Transfac
Matys et al.(2006)
I$GCM_01
0.659
0.659
For this family, TFs with SR scores >
0.607
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000368805
GCM
35
172
FDQFREWPDGYVRFIYSSDEKKAQRHLSGWAMRNTNNHNGHILKKSCLGVVVCTQACTLPDGSRLQLRPAICDKARLKQQKKACPNCHSALELIPCRGHSGYPVTNFWRLDGNAIFFQAKGVHDHPRPESKSETEARR
Links
Other
GCM
family TFs
Other
Homo sapiens
TFs
225 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy