TF Information

GRHL1 *(Homo sapiens)* Grainyhead
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF04516 (CP2)	IPR007604	ENSG00000134317	T199007_2.00	Ensembl (2018-Dec-8)	Link out
NCBI Gene Info: This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development. [provided by RefSeq, Jun 2009]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
GRHL1 M03071_2.00	Homo sapiens	RACYKGWHNDWCMGGTT	AACCKGWHNDWCMRGTY	SELEX Jolma et al.(2013) GRHL1_1	(Direct)	(Direct)
GRHL1 M03072_2.00	Homo sapiens	DAACCGGTTH	DAACCGGTTH	SELEX Jolma et al.(2013) GRHL1_2	(Direct)	(Direct)
GRHL1 M03073_2.00	Homo sapiens	HWAACCGGTTTD	HAAACCGGTTWD	SELEX Jolma et al.(2013) GRHL1_3	(Direct)	(Direct)
GRHL1 M04887_2.00	Homo sapiens	DAACCGGTTH	DAACCGGTTH	SELEX Yin et al.(2017) GRHL1_eDBD_HT-SELEX	(Direct)	(Direct)
GRHL1 M04888_2.00	Homo sapiens	DAACMKGTTH	DAACMKGTTH	SELEX Yin et al.(2017) GRHL1_eDBD_Methyl-HT-SELEX	(Direct)	(Direct)
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
GRHL2 M08129_2.00	Homo sapiens	NNNAACTGGTTTNNN	NNNAAACCAGTTNNN	ChIP-seq Mathelier et al.(2014) MA1105.1	0.732	0.732
GRHL2 M09125_2.00	Homo sapiens	AACYDGYYBDDC	GHHVRRCHRGTT	Misc Kulakovskiy et al.(2013) GRHL2_HUMAN.H11MO.0.A	0.732	0.732
Grhl2 M09126_2.00	Mus musculus	RDCCDGTYYKDC	GHMRRACHGGHY	Misc Kulakovskiy et al.(2013) GRHL2_MOUSE.H11MO.0.A	0.732	0.732
GRHL2 M09558_2.00	Homo sapiens	NRAACHDGHHDDDCHDGTTY	RAACHDGHHHDDCHDGTTYN	Misc Heinz et al.(2010) HBE-GRHL2_GSE46194	0.732	0.732
For this family, TFs with SR scores > 0.700* will likely have a similar motif*

DNA Binding Domains

Protein ID	Domain	From	To	Sequence
ENSP00000324693	Grainyhead	230	442	LSLRMPGMNSEDYVFDSVSGNNFEYTLEASKSLRQKPGDSTMTYLNKGQFYPITLKEVSSSEGIHHPISKVRSVIMVVFAEDKSREDQLRHWKYWHSRQHTAKQRCIDIADYKESFNTISNIEEIAYNAISFTWDINDEAKVFISVNCLSTDFSSQKGVKGLPLNIQVDTYSYNNRSNKPVHRAYCQIKVFCDKGAERKIRDEERKQSKRKVS
ENSP00000384209	Grainyhead	34	253	LVLKPQMLKGELQTRPSQRPSRKAFRRNNFEYTLEASKSLRQKPGDSTMTYLNKGQFYPITLKEVSSSEGIHHPISKVRSVIMVVFAEDKSREDQLRHWKYWHSRQHTAKQRCIDIADYKESFNTISNIEEIAYNAISFTWDINDEAKVFISVNCLSTDFSSQKGVKGLPLNIQVDTYSYNNRSNKPVHRAYCQIKVFCDKGAERKIRDEERKQSKRKVS
ENSP00000418275	Grainyhead	230	442	LSLRMPGMNSEDYVFDSVSGNNFEYTLEASKSLRQKPGDSTMTYLNKGQFYPITLKEVSSSEGIHHPISKVRSVIMVVFAEDKSREDQLRHWKYWHSRQHTAKQRCIDIADYKESFNTISNIEEIAYNAISFTWDINDEAKVFISVNCLSTDFSSQKGVKGLPLNIQVDTYSYNNRSNKPVHRAYCQIKVFCDKGAERKIRDEERKQSKRKGK

Links
Other Grainyhead family TFs
Other *Homo sapiens* TFs

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109 Related TFs

Name	Species	Gene ID	Motif Evidence	SR Score	Action