TFCP2 (Homo sapiens)
Grainyhead

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF04516 (CP2) IPR007604 ENSG00000135457 T199008_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. [provided by RefSeq, Mar 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
TFCP2
M03074_2.00		 Homo sapiens
DAWCCGGTTY
RAACCGGWTH		 SELEX
Jolma et al.(2013)
TFCP2_1		 (Direct) (Direct)
TFCP2
M03075_2.00		 Homo sapiens
WCCGGWWHDAWCYGGW
WCCRGWTHDWWCCGGW		 SELEX
Jolma et al.(2013)
TFCP2_2		 (Direct) (Direct)
TFCP2
M04889_2.00		 Homo sapiens
DWCYRGWHNNDWCYRGWH
DWCYRGWHNNDWCYRGWH		 SELEX
Yin et al.(2017)
TFCP2_eDBD_HT-SELEX		 (Direct) (Direct)
TFCP2
M04890_2.00		 Homo sapiens
DWCYRGWHNNDWCYRGWH
DWCYRGWHNNDWCYRGWH		 SELEX
Yin et al.(2017)
TFCP2_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)
TFCP2
M04891_2.00		 Homo sapiens
AWCYGGTTHNDACCGGTW
WACCGGTHNDAACCRGWT		 SELEX
Yin et al.(2017)
TFCP2_FL_HT-SELEX		 (Direct) (Direct)
TFCP2
M04892_2.00		 Homo sapiens
AWCCGGWTNDAWCCGGTT
AACCGGWTHNAACCGGWT		 SELEX
Yin et al.(2017)
TFCP2_FL_Methyl-HT-SELEX		 (Direct) (Direct)
TFCP2
M10610_2.00		 Homo sapiens
CTKGKTHKDGC
GCHMDAMCMAG		 Transfac
Matys et al.(2006)
V$CP2_01		 (Direct) (Direct)
TFCP2
M10611_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$CP2_02		 (Direct) (Direct)
TFCP2
M10612_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$CP2_Q4		 (Direct) (Direct)
TFCP2
M10613_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$CP2_Q6		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ENSGALG00000002235
M02030_2.00 		Gallus gallus
AACCGGTTA
TAACCGGTT		 PBM
Weirauch et al.(2014)
pTH8565 		0.955 0.955
TFCP2L1
M04885_2.00 		Homo sapiens
DCYRGHHNNNDCYRGH
DCYRGHNNNDDCYRGH		 SELEX
Yin et al.(2017)
TFCP2L1_eDBD_HT-SELEX 		0.852 0.852
UBP1
M04893_2.00 		Homo sapiens
NDCYRGHNNNNDCYRGHN
NDCYRGHNNNNDCYRGHN		 SELEX
Yin et al.(2017)
UBP1_eDBD_HT-SELEX 		0.852 0.852
TFCP2L1
M10609_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$LBP9_01 		0.840 0.840
UBP1
M10614_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$LBP1_Q6_01 		0.852 0.852
TFCP2L1
M04886_2.00 		Homo sapiens
DCYRGHHNNDDCYRGH
DCYRGHHNNDDCYRGH		 SELEX
Yin et al.(2017)
TFCP2L1_eDBD_Methyl-HT-SELEX 		0.840 0.840
Tcfcp2l1
M08029_2.00 		Mus musculus
CYRGYYYHDDCYRGHYYNNNN
NNNNRRDCYRGHHDRRRCYRG		 ChIP-seq
Chen et al.(2011)
SRP000217_Tcfc2pI1 		0.806 0.806
UBP1
M10615_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$LBP1_Q6 		0.852 0.852
Tcfcp2l1
M08030_2.00 		Mus musculus
CYRGYYYHDDCYRGHYYNNNN
NNNNRRDCYRGHHDRRRCYRG		 ChIP-seq
Chen et al.(2011)
SRP000217_Tcfcp2I1 		0.802 0.802
Tcfcp2l1
M09127_2.00 		Mus musculus
DDCYRGYTYHNDCYRGHYB
VRDCYRGHNDRARCYRGHH		 Misc
Kulakovskiy et al.(2013)
TF2L1_MOUSE.H11MO.0.C 		0.802 0.802
UBP1
M04894_2.00 		Homo sapiens
DWCYRGHHNNDDCYRGWH
DWCYRGHHNNDDCYRGWH		 SELEX
Yin et al.(2017)
UBP1_eDBD_Methyl-HT-SELEX 		0.852 0.852
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000257915 Grainyhead 43 260
ENSP00000447991 Grainyhead 45 189
ENSP00000447991 Grainyhead 185 209
ENSP00000449280 Grainyhead 2 162
ENSP00000449742 Grainyhead 42 260

Links

Other Grainyhead family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

207 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action