grh (Drosophila melanogaster)
Grainyhead

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF04516 (CP2) IPR007604 FBgn0259211 T199324_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity; protein homodimerization activity; and sequence-specific DNA binding activity. Involved in several processes, including chitin-based embryonic cuticle biosynthetic process; generation of neurons; and open tracheal system development. Located in nucleus. Is expressed in several structures, including ectoderm; ectoderm anlage; egg chamber; presumptive embryonic/larval system; and thorax. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 28 and posterior polymorphous corneal dystrophy 4. Orthologous to several human genes including GRHL1 (grainyhead like transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
grh
M06209_2.00		 Drosophila melanogaster
MTKGTTYHVY
RBHRAACMAK		 B1H
Zhu et al.(2011)
grh_FlyReg_FBgn0259211		 (Direct) (Direct)
grh
M10616_2.00		 Drosophila melanogaster
NNDDNBGGTDTHDHVN
NBDHDAHACCVNHHNN		 Transfac
Matys et al.(2006)
I$ELF1_01		 (Direct) (Direct)
grh
M10617_2.00		 Drosophila melanogaster Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
I$GRH_01		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0288983 Grainyhead 602 821
FBpp0288984 Grainyhead 871 1091
FBpp0288985 Grainyhead 323 542
FBpp0289765 Grainyhead 602 821
FBpp0289766 Grainyhead 871 1091
FBpp0289768 Grainyhead 266 487
FBpp0297580 Grainyhead 266 487
FBpp0311781 Grainyhead 602 821

Links

Other Grainyhead family TFs
Other Drosophila melanogaster TFs

Invalid Input OrderBy

50 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action