GTF2I (Homo sapiens)
GTF2I-like

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02946 (GTF2I) IPR004212 ENSG00000263001 T203418_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in Williams-Beuren syndrome. There are many closely related genes and pseudogenes for this gene on chromosome 7. This gene also has pseudogenes on chromosomes 9, 13, and 21. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2013]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
GTF2I
M10621_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TFIII_Q6_01
(Direct) (Direct)
GTF2I
M10622_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TFIII_Q6
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000404240 GTF2I-like 112 186
ENSP00000460070 GTF2I-like 112 186
ENSP00000460070 GTF2I-like 361 435
ENSP00000460070 GTF2I-like 466 540
ENSP00000460070 GTF2I-like 571 645
ENSP00000460070 GTF2I-like 733 807
ENSP00000460070 GTF2I-like 868 942
ENSP00000477837 GTF2I-like 112 186
ENSP00000477837 GTF2I-like 320 394
ENSP00000477837 GTF2I-like 425 499
ENSP00000477837 GTF2I-like 530 604
ENSP00000477837 GTF2I-like 692 766
ENSP00000477837 GTF2I-like 827 901
ENSP00000482476 GTF2I-like 112 186
ENSP00000482476 GTF2I-like 340 414
ENSP00000482476 GTF2I-like 445 519
ENSP00000482476 GTF2I-like 550 624
ENSP00000482476 GTF2I-like 712 786
ENSP00000482476 GTF2I-like 847 921
ENSP00000484526 GTF2I-like 112 186
ENSP00000484526 GTF2I-like 341 415
ENSP00000484526 GTF2I-like 446 520
ENSP00000484526 GTF2I-like 551 625
ENSP00000484526 GTF2I-like 713 787
ENSP00000484526 GTF2I-like 848 922

Links

Other GTF2I-like family TFs
Other Homo sapiens TFs

57 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSAMEG00000015241 Ailuropoda melanoleuca ENSAMEG00000015241 I 1.000
Gtf2i Mus musculus ENSMUSG00000060261 I 1.000
ENSMPUG00000016156 Mustela putorius furo ENSMPUG00000016156 I 1.000
ENSPANG00000010876 Papio anubis ENSPANG00000010876 I 1.000
GTF2I Pan troglodytes ENSPTRG00000019293 I 1.000
ENSP00000322542 Macaca fascicularis ENSP00000322542 I 1.000
ENSBTAP00000012902-D1 Bos grunniens ENSBTAP00000012902-D1 I 1.000
GTF2I Sus scrofa ENSSSCG00000007721 I 1.000
GTF2I Pteropus vampyrus ENSPVAG00000005365 I 1.000
GTF2I Felis catus ENSFCAG00000002617 I 1.000
ENSOARG00000011276 Ovis aries ENSOARG00000011276 I 1.000
GTF2I Callithrix jacchus ENSCJAG00000016182 I 1.000
GTF2I Canis familiaris ENSCAFG00000011514 I 1.000
ENSDNOG00000000823 Dasypus novemcinctus ENSDNOG00000000823 I 1.000
GTF2I Bos taurus ENSBTAG00000009780 I 1.000
GTF2I Cavia porcellus ENSCPOG00000004071 I 0.998
GTF2I Macaca mulatta ENSMMUG00000006823 I 0.998
GTF2I Equus caballus ENSECAG00000020289 I 0.998
GTF2I Otolemur garnettii ENSOGAG00000029837 I 0.998
GTF2I Myotis lucifugus ENSMLUG00000002844 I 0.998
Myotis_brandtii_GTF2I_10014287 Myotis brandtii Myotis_brandtii_GTF2I_10014287 I 0.998
GTF2I Loxodonta africana ENSLAFG00000003646 I 0.998
Gtf2i Rattus norvegicus ENSRNOG00000001479 I 0.993
GTF2I Oryctolagus cuniculus ENSOCUG00000002063 I 0.991
GTF2I Vicugna pacos ENSVPAG00000008515 I 0.991
GTF2I Monodelphis domestica ENSMODG00000007022 I 0.987
ENSCSAG00000018227 Chlorocebus sabaeus ENSCSAG00000018227 I 0.980
ENSPPYG00000017484 Pongo abelii ENSPPYG00000017484 I 0.973
GTF2I Ornithorhynchus anatinus ENSOANG00000012919 I 0.962
ENSPSIG00000011811 Pelodiscus sinensis ENSPSIG00000011811 I 0.942
ENSAPLG00000005397 Anas platyrhynchos ENSAPLG00000005397 I 0.936
Afo_R005310 Aptenodytes forsteri Afo_R005310 I 0.933
Pvit_17518 Pogona vitticeps Pvit_17518 I 0.927
Cmyd_10014807 Chelonia mydas Cmyd_10014807 I 0.922
GTF2I Meleagris gallopavo ENSMGAG00000002373 I 0.920
GTF2I Gallus gallus ENSGALG00000021665 I 0.909
ENSNLEG00000001001 Nomascus leucogenys ENSNLEG00000001001 N 0.907
GTF2IRD2B Homo sapiens ENSG00000174428 N 0.907
Alligator_sinensis_CCG003098.5 Alligator sinensis Alligator_sinensis_CCG003098.5 I 0.904
ENSLACG00000018432 Latimeria chalumnae ENSLACG00000018432 I 0.891
Tal_R010800 Tyto alba Tal_R010800 N 0.880
ENSPTRG00000031254 Pan troglodytes ENSPTRG00000031254 N 0.867
ENSCJAG00000014916 Callithrix jacchus ENSCJAG00000014916 N 0.867
ENSGGOG00000028316 Gorilla gorilla ENSGGOG00000028316 N 0.867
XP_002932326 Xenopus tropicalis XP_002932326 I 0.856
Alligator_sinensis_CCG003098.6 Alligator sinensis Alligator_sinensis_CCG003098.6 N 0.853
gtf2i.S Xenopus laevis XB-GENE-1217444 I 0.847
ENSPPYG00000002823 Pongo abelii ENSPPYG00000002823 N 0.836
Aan_R007260 Calypte anna Aan_R007260 I 0.829
Brh_R010179 Buceros rhinoceros Brh_R010179 N 0.827
ENSFCAG00000025671 Felis catus ENSFCAG00000025671 N 0.827
GTF2I Taeniopygia guttata ENSTGUG00000003714 I 0.796
Gfo_R013538 Geospiza fortis Gfo_R013538 I 0.793
Tal_R004165 Tyto alba Tal_R004165 I 0.780
ENSFALG00000007065 Ficedula albicollis ENSFALG00000007065 I 0.776
ENSNLEG00000008741 Nomascus leucogenys ENSNLEG00000008741 I 0.751