ENSBTAP00000012902-D1 (Bos grunniens)
GTF2I-like

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF02946 (GTF2I) IPR004212 ENSBTAP00000012902-D1 T203562_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
GTF2I
M10621_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TFIII_Q6_01
1.000 1.000
GTF2I
M10622_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TFIII_Q6
1.000 1.000
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSBTAP00000012902-D1 GTF2I-like 112 186
ENSBTAP00000012902-D1 GTF2I-like 361 435
ENSBTAP00000012902-D1 GTF2I-like 466 540
ENSBTAP00000012902-D1 GTF2I-like 571 645
ENSBTAP00000012902-D1 GTF2I-like 733 807
ENSBTAP00000012902-D1 GTF2I-like 869 943

Links

Other GTF2I-like family TFs
Other Bos grunniens TFs

46 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
GTF2I Pan troglodytes ENSPTRG00000019293 I 1.000
GTF2I Homo sapiens ENSG00000263001 D 1.000
GTF2I Felis catus ENSFCAG00000002617 I 1.000
ENSMPUG00000016156 Mustela putorius furo ENSMPUG00000016156 I 1.000
GTF2I Pteropus vampyrus ENSPVAG00000005365 I 1.000
ENSPANG00000010876 Papio anubis ENSPANG00000010876 I 1.000
ENSOARG00000011276 Ovis aries ENSOARG00000011276 I 1.000
ENSAMEG00000015241 Ailuropoda melanoleuca ENSAMEG00000015241 I 1.000
ENSP00000322542 Macaca fascicularis ENSP00000322542 I 1.000
GTF2I Sus scrofa ENSSSCG00000007721 I 1.000
GTF2I Bos taurus ENSBTAG00000009780 I 1.000
GTF2I Canis familiaris ENSCAFG00000011514 I 1.000
ENSDNOG00000000823 Dasypus novemcinctus ENSDNOG00000000823 I 1.000
GTF2I Equus caballus ENSECAG00000020289 I 0.998
GTF2I Cavia porcellus ENSCPOG00000004071 I 0.998
Gtf2i Mus musculus ENSMUSG00000060261 I 0.998
GTF2I Otolemur garnettii ENSOGAG00000029837 I 0.998
GTF2I Macaca mulatta ENSMMUG00000006823 I 0.998
Myotis_brandtii_GTF2I_10014287 Myotis brandtii Myotis_brandtii_GTF2I_10014287 I 0.998
GTF2I Myotis lucifugus ENSMLUG00000002844 I 0.998
GTF2I Loxodonta africana ENSLAFG00000003646 I 0.998
Gtf2i Rattus norvegicus ENSRNOG00000001479 I 0.993
GTF2I Vicugna pacos ENSVPAG00000008515 I 0.991
GTF2I Oryctolagus cuniculus ENSOCUG00000002063 I 0.991
GTF2I Callithrix jacchus ENSCJAG00000016182 I 0.989
GTF2I Monodelphis domestica ENSMODG00000007022 I 0.987
ENSCSAG00000018227 Chlorocebus sabaeus ENSCSAG00000018227 I 0.980
ENSPPYG00000017484 Pongo abelii ENSPPYG00000017484 I 0.973
GTF2I Ornithorhynchus anatinus ENSOANG00000012919 I 0.962
ENSPSIG00000011811 Pelodiscus sinensis ENSPSIG00000011811 I 0.942
ENSAPLG00000005397 Anas platyrhynchos ENSAPLG00000005397 I 0.936
Afo_R005310 Aptenodytes forsteri Afo_R005310 I 0.933
Pvit_17518 Pogona vitticeps Pvit_17518 I 0.927
Cmyd_10014807 Chelonia mydas Cmyd_10014807 I 0.922
GTF2I Meleagris gallopavo ENSMGAG00000002373 I 0.920
GTF2I Gallus gallus ENSGALG00000021665 I 0.909
Alligator_sinensis_CCG003098.5 Alligator sinensis Alligator_sinensis_CCG003098.5 I 0.904
ENSLACG00000018432 Latimeria chalumnae ENSLACG00000018432 I 0.891
XP_002932326 Xenopus tropicalis XP_002932326 I 0.856
gtf2i.S Xenopus laevis XB-GENE-1217444 I 0.847
Aan_R007260 Calypte anna Aan_R007260 I 0.829
GTF2I Taeniopygia guttata ENSTGUG00000003714 I 0.796
Gfo_R013538 Geospiza fortis Gfo_R013538 I 0.793
Tal_R004165 Tyto alba Tal_R004165 I 0.780
ENSFALG00000007065 Ficedula albicollis ENSFALG00000007065 I 0.776
ENSNLEG00000008741 Nomascus leucogenys ENSNLEG00000008741 I 0.751