CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
Home
Tools
View cart
Bulk downloads
Database stats
Contact us
Help
Update Log
FAQ
Links
How to cite
nkx2.2b
(
Danio rerio
)
Homeodomain
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00046 (Homeobox)
IPR001356
ENSDARG00000101549
T208733_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within floor plate formation and ventral spinal cord interneuron differentiation. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; prechordal plate; presumptive ectoderm; primary interneuron; and trunk. Orthologous to human NKX2-2 (NK2 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Nkx2-9
M00520_2.00
Mus musculus
NNNRAGDRBN
NVYHCTYNNN
PBM
Berger et al.(2008)
Nkx2-9_3082
0.709
0.877
Nkx2-9
M00800_2.00
Mus musculus
NNRAGDRBNN
NNVYHCTYNN
PBM
Weirauch et al.(2013)
pTH2842
0.709
0.877
Nkx2-9
M09215_2.00
Mus musculus
BTCAAGKRB
VYMCTTGAV
Misc
Kulakovskiy et al.(2013)
NKX28_MOUSE.H11MO.0.C
0.709
0.877
Nkx2-2
M00438_2.00
Mus musculus
NNNRAGDRN
NYHCTYNNN
PBM
Berger et al.(2008)
Nkx2-2_2823
0.703
0.877
Nkx2-2
M09190_2.00
Mus musculus
NTBRAGWGBBN
NVVCWCTYVAN
Misc
Kulakovskiy et al.(2013)
NKX22_MOUSE.H11MO.0.A
0.703
0.877
NKX2-2
M10681_2.00
Homo sapiens
WTAAGTRBTT
AAVYACTTAW
Transfac
Matys et al.(2006)
V$NKX22_01
0.703
0.877
NKX2-2
M10682_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NKX2B_Q3_01
0.703
0.877
NKX2-2
M10683_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NKX2B_Q3
0.703
0.877
vnd
M06551_2.00
Drosophila melanogaster
WYTCAAGTR
YACTTGARW
B1H
Mathelier et al.(2014)
MA0253.1
0.703
0.860
vnd
M06377_2.00
Drosophila melanogaster
WYTCAAGTR
YACTTGARW
B1H
Zhu et al.(2011)
Vnd_Cell_FBgn0003986
0.703
0.860
vnd
M06378_2.00
Drosophila melanogaster
KYTSAAGWGY
RCWCTTSARM
B1H
Zhu et al.(2011)
vnd_FlyReg_FBgn0003986
0.703
0.860
vnd
M06379_2.00
Drosophila melanogaster
BTBAAGTR
YACTTVAV
B1H
Zhu et al.(2011)
Vnd_SOLEXA_FBgn0003986
0.703
0.860
vnd
M09683_2.00
Drosophila melanogaster
TCAAGTGB
VCACTTGA
Misc
Kulakovskiy et al.(2009)
vnd
0.703
0.860
NKX2-8
M00301_2.00
Homo sapiens
NNRAKDRB
VYHMTYNN
PBM
Barrera et al.(2016)
NKX2-8_A94T
0.677
0.877
NKX2-8
M00302_2.00
Homo sapiens
NNRAGDRB
VYHCTYNN
PBM
Barrera et al.(2016)
NKX2-8_REF
0.677
0.860
NKX2-8
M05149_2.00
Homo sapiens
BTSRAGTGBN
NVCACTYSAV
SELEX
Yin et al.(2017)
NKX2-8_FL_HT-SELEX
0.677
0.860
NKX2-8
M09145_2.00
Homo sapiens
BTCAAGKRB
VYMCTTGAV
Misc
Kulakovskiy et al.(2013)
NKX28_HUMAN.H11MO.0.C
0.677
0.860
NKX2-8
M05150_2.00
Homo sapiens
GCARTAACGACATC
GATGTCGTTAYTGC
SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_1
0.677
0.860
NKX2-8
M05151_2.00
Homo sapiens
BTSAAGTGBN
NVCACTTSAV
SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_2
0.677
0.860
NKX2-8
M05152_2.00
Homo sapiens
BTBAACGAB
VTCGTTVAV
SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_3
0.677
0.860
ceh-22
M00376_2.00
Caenorhabditis elegans
WBRAGTRBNN
NNVYACTYVW
PBM
Berger et al.(2006)
Ceh-22
0.660
0.772
scro
M03854_2.00
Drosophila melanogaster
NNBRMGTGB
VCACKYVNN
SELEX
Nitta et al.(2015)
scro_1
0.655
0.825
Nkx2-1
M00385_2.00
Mus musculus
NNRAGDRN
NYHCTYNN
PBM
Berger et al.(2008)
Titf1_1722
0.638
0.807
Nkx2-4
M00514_2.00
Mus musculus
NNRAGDRBNN
NNVYHCTYNN
PBM
Berger et al.(2008)
Nkx2-4_3074
0.638
0.807
NKX2-1
M09146_2.00
Homo sapiens
BTKGAGWGBN
NVCWCTCMAV
Misc
Kulakovskiy et al.(2013)
NKX21_HUMAN.H11MO.0.A
0.638
0.807
Nkx2-1
M09171_2.00
Mus musculus
NBTKGAGWGB
VCWCTCMAVN
Misc
Kulakovskiy et al.(2013)
NKX21_MOUSE.H11MO.0.A
0.638
0.807
Nkx2-1
M09563_2.00
Mus musculus
BTBRAGWGBH
DVCWCTYVAV
Misc
Heinz et al.(2010)
LungAC-Nkx2.1_GSE43252
0.638
0.807
NKX2-1
M10694_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TITF1_Q3
0.638
0.807
NKX2-1
M10695_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TTF1_Q5_01
0.638
0.807
NKX2-1
M10696_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TTF1_Q5
0.638
0.807
NKX2-1
M10697_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TTF1_Q6
0.638
0.807
ceh-24
M02181_2.00
Caenorhabditis elegans
NNRAKWRNN
NNYWMTYNN
PBM
Weirauch et al.(2014)
pTH6327
0.636
0.737
Nkx2-3
M00497_2.00
Mus musculus
NNRAGDRNN
NNYHCTYNN
PBM
Berger et al.(2008)
Nkx2-3_3435
0.610
0.789
NKX2-3
M05042_2.00
Homo sapiens
NNBAAGTGBN
NVCACTTVNN
SELEX
Yin et al.(2017)
NKX2-3_eDBD_HT-SELEX
0.610
0.789
NKX2-3
M05045_2.00
Homo sapiens
BNBAAGTGBN
NVCACTTVNV
SELEX
Yin et al.(2017)
NKX2-3_FL_HT-SELEX
0.610
0.789
NKX2-3
M05043_2.00
Homo sapiens
BNBAAGTGBN
NVCACTTVNV
SELEX
Yin et al.(2017)
NKX2-3_eDBD_Methyl-HT-SELEX_1
0.610
0.789
NKX2-3
M05044_2.00
Homo sapiens
SDYAACGHB
VDCGTTRHS
SELEX
Yin et al.(2017)
NKX2-3_eDBD_Methyl-HT-SELEX_2
0.610
0.789
NKX2-3
M05046_2.00
Homo sapiens
BNBAAGTGBN
NVCACTTVNV
SELEX
Yin et al.(2017)
NKX2-3_FL_Methyl-HT-SELEX_1
0.610
0.789
NKX2-3
M05047_2.00
Homo sapiens
SWYAACSHB
VDSGTTRWS
SELEX
Yin et al.(2017)
NKX2-3_FL_Methyl-HT-SELEX_2
0.610
0.789
NKX2-5
M00323_2.00
Homo sapiens
NWYAAGTGSNN
NNSCACTTRWN
PBM
Barrera et al.(2016)
NKX2-5_REF
0.608
0.737
Nkx2-5
M00404_2.00
Mus musculus
NNNRAGDRBN
NVYHCTYNNN
PBM
Berger et al.(2008)
Nkx2-5_3436
0.608
0.737
NKX2-5
M05346_2.00
Homo sapiens
BHYAAGTGBN
NVCACTTRDV
SELEX
Yin et al.(2017)
NKX2-5_FL_HT-SELEX
0.608
0.737
Nkx2-5
M02686_2.00
Mus musculus
WTAAKWK
MWMTTAW
SELEX
Mathelier et al.(2014)
MA0063.1
0.608
0.737
Nkx2-5
M08136_2.00
Mus musculus
SYTGAGWGSYH
DRSCWCTCARS
ChIP-seq
Mathelier et al.(2014)
MA0503.1
0.608
0.737
NKX2-5
M09163_2.00
Homo sapiens
BKRAGWGV
BCWCTYMV
Misc
Kulakovskiy et al.(2013)
NKX25_HUMAN.H11MO.0.B
0.608
0.737
Nkx2-5
M09177_2.00
Mus musculus
NBYBRAGTGS
SCACTYVRVN
Misc
Kulakovskiy et al.(2013)
NKX25_MOUSE.H11MO.0.A
0.608
0.737
Nkx2-5
M09567_2.00
Mus musculus
HBRAGWGBNN
NNVCWCTYVD
Misc
Heinz et al.(2010)
HL1-Nkx2.5.biotin_GSE21529
0.608
0.737
NKX2-5
M10742_2.00
Homo sapiens
TYAAGTG
CACTTRA
Transfac
Matys et al.(2006)
V$NKX25_01
0.608
0.737
NKX2-5
M10743_2.00
Homo sapiens
CWTAATTV
BAATTAWG
Transfac
Matys et al.(2006)
V$NKX25_02
0.608
0.737
NKX2-5
M10744_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NKX25_Q5
0.608
0.737
NKX2-5
M10745_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NKX25_Q6
0.608
0.737
NKX2-5
M05347_2.00
Homo sapiens
BTYAAGTGGN
NCCACTTRAV
SELEX
Yin et al.(2017)
NKX2-5_FL_Methyl-HT-SELEX_1
0.608
0.737
NKX2-5
M05348_2.00
Homo sapiens
BTYAACGAB
VTCGTTRAV
SELEX
Yin et al.(2017)
NKX2-5_FL_Methyl-HT-SELEX_2
0.608
0.737
NKX2-5
M00322_2.00
Homo sapiens
NNNRNNN
NNNYNNN
PBM
Barrera et al.(2016)
NKX2-5_R190C
0.608
0.719
NKX2-5
M00324_2.00
Homo sapiens
NHNNNNN
NNNNNDN
PBM
Barrera et al.(2016)
NKX2-5_T178M
0.608
0.719
ceh-28
M08210_2.00
Caenorhabditis elegans
AATCGATW
WATCGATT
ChIP-seq
Contrino et al.(2012)
Mw138
0.604
0.649
NKX2-5
M00321_2.00
Homo sapiens
HNAAGTRBNN
NNVYACTTND
PBM
Barrera et al.(2016)
NKX2-5_R161P
0.603
0.719
For this family, TFs with SR scores >
0.599
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSDARP00000131321
Homeodomain
96
152
RKRRILFSKTQTFELERRFRQQRYLSAPEREHLAKLLHLTPTQVKIWFQNHRYKVKR
Links
Other
Homeodomain
family TFs
Other
Danio rerio
TFs
775 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy