CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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irx1a
(
Danio rerio
)
Homeodomain
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00046 (Homeobox)
IPR001356
ENSDARG00000101831
T208735_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including central nervous system neuron differentiation; embryonic pectoral fin morphogenesis; and sensory organ development. Predicted to be active in nucleus. Is expressed in several structures, including liver; nervous system; neural plate; pericardial region; and pleuroperitoneal region. Orthologous to human IRX1 (iroquois homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Irx3
M00453_2.00
Mus musculus
NNDACAHNNN
NNNDTGTHNN
PBM
Berger et al.(2008)
Irx3_0920
0.867
1.000
Irx3
M00454_2.00
Mus musculus
NNDACWHN
NDWGTHNN
PBM
Berger et al.(2008)
Irx3_2226
0.867
1.000
Irx3
M03266_2.00
Mus musculus
WWTKTCATGTWR
YWACATGAMAWW
SELEX
Jolma et al.(2013)
Irx3_1
0.867
1.000
IRX1
M05283_2.00
Homo sapiens
DDCRHNNNNNNNNDYGHH
DDCRHNNNNNNNNDYGHH
SELEX
Yin et al.(2017)
IRX1_eDBD_HT-SELEX
0.867
1.000
IRX3
M05319_2.00
Homo sapiens
DACAHGNWWWWNCDTGTH
DACAHGNWWWWNCDTGTH
SELEX
Yin et al.(2017)
IRX3_eDBD_HT-SELEX
0.867
1.000
IRX1
M05284_2.00
Homo sapiens
NNCRHNNNNNNNNDYVHN
NDBRHNNNNNNNNDYGNN
SELEX
Yin et al.(2017)
IRX1_eDBD_Methyl-HT-SELEX
0.867
1.000
IRX3
M05320_2.00
Homo sapiens
DACRYRHNWWNDYKCGTW
WACGMRHNWWNDYRYGTH
SELEX
Yin et al.(2017)
IRX3_eDBD_Methyl-HT-SELEX
0.867
1.000
mirr
M06514_2.00
Drosophila melanogaster
WWACA
TGTWW
B1H
Mathelier et al.(2014)
MA0233.1
0.834
0.947
mirr
M06305_2.00
Drosophila melanogaster
NDNWWACA
TGTWWNHN
B1H
Zhu et al.(2011)
Mirr_Cell_FBgn0014343
0.834
0.947
mirr
M06306_2.00
Drosophila melanogaster
DDWACA
TGTWHH
B1H
Zhu et al.(2011)
Mirr_SOLEXA_FBgn0014343
0.834
0.947
SNAPOd2T00005194001
M02229_2.00
Oikopleura dioica
NNTACATGTDN
NHACATGTANN
PBM
Weirauch et al.(2014)
pTH5976
0.810
0.772
For this family, TFs with SR scores >
0.599
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSDARP00000137032
Homeodomain
118
174
PKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKK
ENSDARP00000137879
Homeodomain
118
174
PKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKK
Links
Other
Homeodomain
family TFs
Other
Danio rerio
TFs
292 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy