IRX4 (Homo sapiens)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox) IPR001356 ENSG00000113430 T209806_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell development; neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within heart development. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Irx4
M00416_2.00 		Mus musculus
NNNDAMAH
DTKTHNNN		 PBM
Berger et al.(2008)
Irx4_2242 		0.867 1.000
Irx6
M00456_2.00 		Mus musculus
NNDAHWN
NWDTHNN		 PBM
Berger et al.(2008)
Irx6_2623 		0.790 0.929
ara
M06518_2.00 		Drosophila melanogaster
WWACA
TGTWW		 B1H
Mathelier et al.(2014)
MA0210.1 		0.788 0.929
ara
M06313_2.00 		Drosophila melanogaster
TGTWWWNN
NNWWWACA		 B1H
Zhu et al.(2011)
Ara_Cell_FBgn0015904 		0.788 0.929
ara
M06314_2.00 		Drosophila melanogaster
DWWACA
TGTWWH		 B1H
Zhu et al.(2011)
Ara_SOLEXA_FBgn0015904 		0.788 0.929
caup
M06519_2.00 		Drosophila melanogaster
WAACA
TGTTW		 B1H
Mathelier et al.(2014)
MA0217.1 		0.780 0.893
caup
M06315_2.00 		Drosophila melanogaster
HWDWAACA
TGTTWHWD		 B1H
Zhu et al.(2011)
Caup_Cell_FBgn0015919 		0.780 0.893
caup
M06316_2.00 		Drosophila melanogaster
NDDACA
TGTHHN		 B1H
Zhu et al.(2011)
Caup_SOLEXA_FBgn0015919 		0.780 0.893
Irx2
M00386_2.00 		Mus musculus
NNDACAHNN
NNDTGTHNN		 PBM
Berger et al.(2008)
Irx2_0900 		0.780 0.893
Irx5
M00455_2.00 		Mus musculus
NNNDACAHN
NDTGTHNNN		 PBM
Berger et al.(2008)
Irx5_2385 		0.780 0.893
IRX2
M03212_2.00 		Homo sapiens
NDACAYRACAHN
NDTGTYRTGTHN		 SELEX
Jolma et al.(2013)
IRX2_1 		0.780 0.893
IRX5
M03222_2.00 		Homo sapiens
NDACAYRACAHN
NDTGTYRTGTHN		 SELEX
Jolma et al.(2013)
IRX5_1 		0.780 0.893
IRX5
M05315_2.00 		Homo sapiens
NBDTGTHNDACAYVN
NBRTGTHNDACAHVN		 SELEX
Yin et al.(2017)
IRX5_eDBD_HT-SELEX 		0.780 0.893
IRX5
M05316_2.00 		Homo sapiens
WYRYGHHNHAYRYRY
RYRYRTDNDDCRYRW		 SELEX
Yin et al.(2017)
IRX5_eDBD_Methyl-HT-SELEX 		0.780 0.893
For this family, TFs with SR scores > 0.599 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000231357 Homeodomain 144 202
ENSP00000423161 Homeodomain 144 202
ENSP00000424235 Homeodomain 144 202
ENSP00000481396 Homeodomain 170 228
ENSP00000482393 Homeodomain 170 228

Links

Other Homeodomain family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

390 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action