HOXC13 (Homo sapiens)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox) IPR001356 ENSG00000123364 T209823_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the development of hair, nail, and filiform papilla. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
HOXC13
M03129_2.00
Homo sapiens
NTTTTATTRS

SYAATAAAAN
SELEX
Jolma et al.(2013)
HOXC13_1
(Direct) (Direct)
HOXC13
M03130_2.00
Homo sapiens
NCTCGTAAAAH

DTTTTACGAGN
SELEX
Jolma et al.(2013)
HOXC13_2
(Direct) (Direct)
HOXC13
M05072_2.00
Homo sapiens
RKTTTATKGSN

NSCMATAAAMY
SELEX
Yin et al.(2017)
HOXC13_eDBD_HT-SELEX_1
(Direct) (Direct)
HOXC13
M05073_2.00
Homo sapiens
BCTCGTAAAMH

DKTTTACGAGV
SELEX
Yin et al.(2017)
HOXC13_eDBD_HT-SELEX_2
(Direct) (Direct)
HOXC13
M05074_2.00
Homo sapiens
BCTCGTAAAAH

DTTTTACGAGV
SELEX
Yin et al.(2017)
HOXC13_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
HOXC13
M10680_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HOXC13_Q2
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Hoxc13
M00389_2.00
Mus musculus
NTTWAYDRNN

NNYHRTWAAN
PBM
Berger et al.(2008)
Hoxc13_3127
0.867 1.000
Hoxa13
M00473_2.00
Mus musculus
NTTWAYDRN

NYHRTWAAN
PBM
Berger et al.(2008)
Hoxa13_3126
0.862 0.930
HOXA13
M03098_2.00
Homo sapiens
DKTTTATKRS

SYMATAAAMH
SELEX
Jolma et al.(2013)
HOXA13_1
0.862 0.930
HOXA13
M03099_2.00
Homo sapiens
NCTCGTAAAHN

NDTTTACGAGN
SELEX
Jolma et al.(2013)
HOXA13_2
0.862 0.930
HOXA13
M03100_2.00
Homo sapiens
DKTTTATKRS

SYMATAAAMH
SELEX
Jolma et al.(2013)
HOXA13_3
0.862 0.930
HOXA13
M03101_2.00
Homo sapiens
NCTCGTAAAAH

DTTTTACGAGN
SELEX
Jolma et al.(2013)
HOXA13_4
0.862 0.930
HOXA13
M04977_2.00
Homo sapiens
DTTTTATKGGB

VCCMATAAAAH
SELEX
Yin et al.(2017)
HOXA13_eDBD_HT-SELEX_1
0.862 0.930
HOXA13
M04978_2.00
Homo sapiens
NCTCGTAAAHN

NDTTTACGAGN
SELEX
Yin et al.(2017)
HOXA13_eDBD_HT-SELEX_2
0.862 0.930
HOXA13
M04981_2.00
Homo sapiens
DTTTTATKRSN

NSYMATAAAAH
SELEX
Yin et al.(2017)
HOXA13_FL_HT-SELEX_1
0.862 0.930
HOXA13
M04982_2.00
Homo sapiens
NCTCGTAAAWH

DWTTTACGAGN
SELEX
Yin et al.(2017)
HOXA13_FL_HT-SELEX_2
0.862 0.930
HOXA13
M09134_2.00
Homo sapiens
VDTWTWATKGS

SCMATWAWAHB
Misc
Kulakovskiy et al.(2013)
HXA13_HUMAN.H11MO.0.C
0.862 0.930
Hoxa13
M09202_2.00
Mus musculus
VDTWTWATKGS

SCMATWAWAHB
Misc
Kulakovskiy et al.(2013)
HXA13_MOUSE.H11MO.0.C
0.862 0.930
HOXA13
M10653_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HOXA13_01
0.862 0.930
HOXA13
M10654_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HOXA13_02
0.862 0.930
HOXA13
M04979_2.00
Homo sapiens
DTTTTATTRSN

NSYAATAAAAH
SELEX
Yin et al.(2017)
HOXA13_eDBD_Methyl-HT-SELEX_1
0.862 0.930
HOXA13
M04980_2.00
Homo sapiens
NCTCGTAAAHN

NDTTTACGAGN
SELEX
Yin et al.(2017)
HOXA13_eDBD_Methyl-HT-SELEX_2
0.862 0.930
HOXA13
M04983_2.00
Homo sapiens
DKTTTATTGBN

NVCAATAAAMH
SELEX
Yin et al.(2017)
HOXA13_FL_Methyl-HT-SELEX_1
0.862 0.930
HOXA13
M04984_2.00
Homo sapiens
NCTCGTAAAWH

DWTTTACGAGN
SELEX
Yin et al.(2017)
HOXA13_FL_Methyl-HT-SELEX_2
0.862 0.930
HOXD13
M00299_2.00
Homo sapiens
NTTWAYDDN

NHHRTWAAN
PBM
Barrera et al.(2016)
HOXD13_REF
0.834 0.860
Hoxd13
M00394_2.00
Mus musculus
NWTHRYDDN

NHHRYDAWN
PBM
Berger et al.(2008)
Hoxd13_2356
0.834 0.860
HOXD13
M03141_2.00
Homo sapiens
DTTTTATKRS

SYMATAAAAH
SELEX
Jolma et al.(2013)
HOXD13_1
0.834 0.860
HOXD13
M03142_2.00
Homo sapiens
BCTCGTAAAAH

DTTTTACGAGV
SELEX
Jolma et al.(2013)
HOXD13_2
0.834 0.860
Hoxd13
M03247_2.00
Mus musculus
DKTTTATTRS

SYAATAAAMH
SELEX
Jolma et al.(2013)
Hoxd13_1
0.834 0.860
Hoxd13
M03248_2.00
Mus musculus
DDTTTAYKAGN

NCTMRTAAAHH
SELEX
Jolma et al.(2013)
Hoxd13_2
0.834 0.860
HOXD13
M05122_2.00
Homo sapiens
GKTTTATKGSS

SSCMATAAAMC
SELEX
Yin et al.(2017)
HOXD13_eDBD_HT-SELEX_1
0.834 0.860
HOXD13
M05123_2.00
Homo sapiens
BCTCGTAAAMH

DKTTTACGAGV
SELEX
Yin et al.(2017)
HOXD13_eDBD_HT-SELEX_2
0.834 0.860
HOXD13
M10689_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HOXD13_Q6
0.834 0.860
HOXD13
M00295_2.00
Homo sapiens
NTTWAYDDN

NHHRTWAAN
PBM
Barrera et al.(2016)
HOXD13_N298S
0.834 0.860
HOXD13
M05124_2.00
Homo sapiens
DDTTTATTRBB

VVYAATAAAHH
SELEX
Yin et al.(2017)
HOXD13_eDBD_Methyl-HT-SELEX_1
0.834 0.860
HOXD13
M05125_2.00
Homo sapiens
VCTCGTAAAAH

DTTTTACGAGB
SELEX
Yin et al.(2017)
HOXD13_eDBD_Methyl-HT-SELEX_2
0.834 0.860
HOXD13
M00300_2.00
Homo sapiens
WTTTATDR

YHATAAAW
PBM
Barrera et al.(2016)
HOXD13_S316C
0.834 0.842
HOXD13
M00293_2.00
Homo sapiens
NTTWAYDDNN

NNHHRTWAAN
PBM
Barrera et al.(2016)
HOXD13_I297V
0.834 0.842
hoxd13a
M02081_2.00
Danio rerio
WTTTATDR

YHATAAAW
PBM
Weirauch et al.(2014)
pTH6143
0.832 0.825
HOXD13
M00298_2.00
Homo sapiens
NTTWAYDDN

NHHRTWAAN
PBM
Barrera et al.(2016)
HOXD13_R306W
0.826 0.842
HOXD13
M00294_2.00
Homo sapiens
THGTWAAW

WTTWACDA
PBM
Barrera et al.(2016)
HOXD13_I322L
0.816 0.842
HOXB13
M02092_2.00
Homo sapiens
NTTWAYDDNN

NNHHRTWAAN
PBM
Weirauch et al.(2014)
pTH5808
0.713 0.807
Hoxb13
M00505_2.00
Mus musculus
NTTWAYDDNN

NNHHRTWAAN
PBM
Berger et al.(2008)
Hoxb13_3479
0.713 0.807
HOXB13
M03175_2.00
Homo sapiens
DTTTTATKGG

CCMATAAAAH
SELEX
Jolma et al.(2013)
HOXB13_1
0.713 0.807
HOXB13
M03176_2.00
Homo sapiens
BCTCGTAAAAH

DTTTTACGAGV
SELEX
Jolma et al.(2013)
HOXB13_2
0.713 0.807
HOXB13
M05201_2.00
Homo sapiens
DTTTTATKGGN

NCCMATAAAAH
SELEX
Yin et al.(2017)
HOXB13_eDBD_HT-SELEX_1
0.713 0.807
HOXB13
M05202_2.00
Homo sapiens
NCTCGTAAAHH

DDTTTACGAGN
SELEX
Yin et al.(2017)
HOXB13_eDBD_HT-SELEX_2
0.713 0.807
HOXB13
M09149_2.00
Homo sapiens
TTTTATDRSN

NSYHATAAAA
Misc
Kulakovskiy et al.(2013)
HXB13_HUMAN.H11MO.0.A
0.713 0.807
HOXB13
M05203_2.00
Homo sapiens
NCTCGTAAAAH

DTTTTACGAGN
SELEX
Yin et al.(2017)
HOXB13_eDBD_Methyl-HT-SELEX
0.713 0.807
cad
M03780_2.00
Drosophila melanogaster
NKTTTATKRCHB

VDGYMATAAAMN
SELEX
Nitta et al.(2015)
cad_1
0.606 0.561
cad
M03781_2.00
Drosophila melanogaster
NDTTTATKRCHN

NDGYMATAAAHN
SELEX
Nitta et al.(2015)
cad_2
0.606 0.561
cad
M03782_2.00
Drosophila melanogaster
NDTTTATKRCNB

VNGYMATAAAHN
SELEX
Nitta et al.(2015)
cad_3
0.606 0.561
cad
M03783_2.00
Drosophila melanogaster
NNTTTAYGRYNN

NNRYCRTAAANN
SELEX
Nitta et al.(2015)
cad_4
0.606 0.561
cad
M06223_2.00
Drosophila melanogaster
HTTWATTR

YAATWAAD
B1H
Zhu et al.(2011)
Cad_Cell_FBgn0000251
0.606 0.561
cad
M06224_2.00
Drosophila melanogaster
RBYVDAAMV

BKTTHBRVY
B1H
Zhu et al.(2011)
cad_FlyReg_FBgn0000251
0.606 0.561
cad
M06225_2.00
Drosophila melanogaster
NTTWATKR

YMATWAAN
B1H
Zhu et al.(2011)
Cad_SOLEXA_FBgn0000251
0.606 0.561
cad
M08420_2.00
Drosophila melanogaster
DTTTTATKRYY

RRYMATAAAAH
ChIP-chip
Mathelier et al.(2014)
MA0216.2
0.606 0.561
cad
M09580_2.00
Drosophila melanogaster
DTTTAYGRYN

NRYCRTAAAH
Misc
Heinz et al.(2010)
Drosophila-Embryos_modEncode
0.606 0.561
cad
M09674_2.00
Drosophila melanogaster
HTTTATKRBY

RVYMATAAAD
Misc
Kulakovskiy et al.(2009)
cad
0.606 0.561
cad
M10783_2.00
Drosophila melanogaster Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
I$CAD_Q6
0.606 0.561
HOXD13
M00296_2.00
Homo sapiens
GKATAAAH

DTTTATMC
PBM
Barrera et al.(2016)
HOXD13_Q325K
0.601 0.842
HOXD13
M00297_2.00
Homo sapiens
NWTWRKNNNN

NNNNMYWAWN
PBM
Barrera et al.(2016)
HOXD13_Q325R
0.601 0.842
For this family, TFs with SR scores > 0.599 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000243056 Homeodomain 261 317

Links

Other Homeodomain family TFs
Other Homo sapiens TFs

275 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ALNC14_059010 Albugo laibachii ALNC14_059010 N 0.000
estExt_fgenesh1_pg.C_80097 Phytophthora capsici estExt_fgenesh1_pg.C_80097 N 0.000
F443_18208 Phytophthora parasitica F443_18208 N 0.000
fgenesh_scip_prom.28083.8498 Phytophthora lateralis fgenesh_scip_prom.28083.8498 N 0.000
gw1.2.1819.1 Fragilariopsis cylindrus gw1.2.1819.1 I 0.000
maker-pir_contig_380-snap-gene-0.13 Pythium irregulare maker-pir_contig_380-snap-gene-0.13 N 0.000
maker-pve_contig_274-fgenesh-gene-0.2 Pythium vexans maker-pve_contig_274-fgenesh-gene-0.2 N 0.000
Phyra76681 Phytophthora ramorum Phyra76681 N 0.000
Physo140584 Phytophthora sojae Physo140584 N 0.000
PITG_13032 Phytophthora infestans PITG_13032 N 0.000
PYU1_G000358 Pythium ultimum PYU1_G000358 N 0.000
snap_masked-par_contig_136-abinit-gene-0.22 Pythium arrhenomanes snap_masked-par_contig_136-abinit-gene-0.22 N 0.000
SPRG_02234 Saprolegnia parasitica SPRG_02234 N 0.000