NKX2-2 (Homo sapiens)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox) IPR001356 ENSG00000125820 T209829_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
NKX2-2
M10681_2.00
Homo sapiens
WTAAGTRBTT

AAVYACTTAW
Transfac
Matys et al.(2006)
V$NKX22_01
(Direct) (Direct)
NKX2-2
M10682_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NKX2B_Q3_01
(Direct) (Direct)
NKX2-2
M10683_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NKX2B_Q3
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Nkx2-2
M00438_2.00
Mus musculus
NNNRAGDRN

NYHCTYNNN
PBM
Berger et al.(2008)
Nkx2-2_2823
0.867 1.000
Nkx2-2
M09190_2.00
Mus musculus
NTBRAGWGBBN

NVVCWCTYVAN
Misc
Kulakovskiy et al.(2013)
NKX22_MOUSE.H11MO.0.A
0.867 1.000
vnd
M06551_2.00
Drosophila melanogaster
WYTCAAGTR

YACTTGARW
B1H
Mathelier et al.(2014)
MA0253.1
0.850 0.965
vnd
M06377_2.00
Drosophila melanogaster
WYTCAAGTR

YACTTGARW
B1H
Zhu et al.(2011)
Vnd_Cell_FBgn0003986
0.850 0.965
vnd
M06378_2.00
Drosophila melanogaster
KYTSAAGWGY

RCWCTTSARM
B1H
Zhu et al.(2011)
vnd_FlyReg_FBgn0003986
0.850 0.965
vnd
M06379_2.00
Drosophila melanogaster
BTBAAGTR

YACTTVAV
B1H
Zhu et al.(2011)
Vnd_SOLEXA_FBgn0003986
0.850 0.965
vnd
M09683_2.00
Drosophila melanogaster
TCAAGTGB

VCACTTGA
Misc
Kulakovskiy et al.(2009)
vnd
0.850 0.965
Nkx2-9
M00520_2.00
Mus musculus
NNNRAGDRBN

NVYHCTYNNN
PBM
Berger et al.(2008)
Nkx2-9_3082
0.843 0.912
Nkx2-9
M00800_2.00
Mus musculus
NNRAGDRBNN

NNVYHCTYNN
PBM
Weirauch et al.(2013)
pTH2842
0.843 0.912
Nkx2-9
M09215_2.00
Mus musculus
BTCAAGKRB

VYMCTTGAV
Misc
Kulakovskiy et al.(2013)
NKX28_MOUSE.H11MO.0.C
0.843 0.912
NKX2-8
M00302_2.00
Homo sapiens
NNRAGDRB

VYHCTYNN
PBM
Barrera et al.(2016)
NKX2-8_REF
0.811 0.912
NKX2-8
M05149_2.00
Homo sapiens
BTSRAGTGBN

NVCACTYSAV
SELEX
Yin et al.(2017)
NKX2-8_FL_HT-SELEX
0.811 0.912
NKX2-8
M09145_2.00
Homo sapiens
BTCAAGKRB

VYMCTTGAV
Misc
Kulakovskiy et al.(2013)
NKX28_HUMAN.H11MO.0.C
0.811 0.912
NKX2-8
M05150_2.00
Homo sapiens
GCARTAACGACATC

GATGTCGTTAYTGC
SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_1
0.811 0.912
NKX2-8
M05151_2.00
Homo sapiens
BTSAAGTGBN

NVCACTTSAV
SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_2
0.811 0.912
NKX2-8
M05152_2.00
Homo sapiens
BTBAACGAB

VTCGTTVAV
SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_3
0.811 0.912
NKX2-8
M00301_2.00
Homo sapiens
NNRAKDRB

VYHMTYNN
PBM
Barrera et al.(2016)
NKX2-8_A94T
0.811 0.895
ceh-22
M00376_2.00
Caenorhabditis elegans
WBRAGTRBNN

NNVYACTYVW
PBM
Berger et al.(2006)
Ceh-22
0.807 0.860
scro
M03854_2.00
Drosophila melanogaster
NNBRMGTGB

VCACKYVNN
SELEX
Nitta et al.(2015)
scro_1
0.799 0.895
Nkx2-1
M00385_2.00
Mus musculus
NNRAGDRN

NYHCTYNN
PBM
Berger et al.(2008)
Titf1_1722
0.798 0.895
Nkx2-4
M00514_2.00
Mus musculus
NNRAGDRBNN

NNVYHCTYNN
PBM
Berger et al.(2008)
Nkx2-4_3074
0.798 0.895
NKX2-1
M09146_2.00
Homo sapiens
BTKGAGWGBN

NVCWCTCMAV
Misc
Kulakovskiy et al.(2013)
NKX21_HUMAN.H11MO.0.A
0.798 0.895
Nkx2-1
M09171_2.00
Mus musculus
NBTKGAGWGB

VCWCTCMAVN
Misc
Kulakovskiy et al.(2013)
NKX21_MOUSE.H11MO.0.A
0.798 0.895
Nkx2-1
M09563_2.00
Mus musculus
BTBRAGWGBH

DVCWCTYVAV
Misc
Heinz et al.(2010)
LungAC-Nkx2.1_GSE43252
0.798 0.895
NKX2-1
M10694_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TITF1_Q3
0.798 0.895
NKX2-1
M10695_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TTF1_Q5_01
0.798 0.895
NKX2-1
M10696_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TTF1_Q5
0.798 0.895
NKX2-1
M10697_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TTF1_Q6
0.798 0.895
ceh-24
M02181_2.00
Caenorhabditis elegans
NNRAKWRNN

NNYWMTYNN
PBM
Weirauch et al.(2014)
pTH6327
0.784 0.825
NKX2-5
M00323_2.00
Homo sapiens
NWYAAGTGSNN

NNSCACTTRWN
PBM
Barrera et al.(2016)
NKX2-5_REF
0.742 0.789
Nkx2-5
M00404_2.00
Mus musculus
NNNRAGDRBN

NVYHCTYNNN
PBM
Berger et al.(2008)
Nkx2-5_3436
0.742 0.789
NKX2-5
M05346_2.00
Homo sapiens
BHYAAGTGBN

NVCACTTRDV
SELEX
Yin et al.(2017)
NKX2-5_FL_HT-SELEX
0.742 0.789
Nkx2-5
M02686_2.00
Mus musculus
WTAAKWK

MWMTTAW
SELEX
Mathelier et al.(2014)
MA0063.1
0.742 0.789
Nkx2-5
M08136_2.00
Mus musculus
SYTGAGWGSYH

DRSCWCTCARS
ChIP-seq
Mathelier et al.(2014)
MA0503.1
0.742 0.789
NKX2-5
M09163_2.00
Homo sapiens
BKRAGWGV

BCWCTYMV
Misc
Kulakovskiy et al.(2013)
NKX25_HUMAN.H11MO.0.B
0.742 0.789
Nkx2-5
M09177_2.00
Mus musculus
NBYBRAGTGS

SCACTYVRVN
Misc
Kulakovskiy et al.(2013)
NKX25_MOUSE.H11MO.0.A
0.742 0.789
Nkx2-5
M09567_2.00
Mus musculus
HBRAGWGBNN

NNVCWCTYVD
Misc
Heinz et al.(2010)
HL1-Nkx2.5.biotin_GSE21529
0.742 0.789
NKX2-5
M10742_2.00
Homo sapiens
TYAAGTG

CACTTRA
Transfac
Matys et al.(2006)
V$NKX25_01
0.742 0.789
NKX2-5
M10743_2.00
Homo sapiens
CWTAATTV

BAATTAWG
Transfac
Matys et al.(2006)
V$NKX25_02
0.742 0.789
NKX2-5
M10744_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NKX25_Q5
0.742 0.789
NKX2-5
M10745_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NKX25_Q6
0.742 0.789
NKX2-5
M05347_2.00
Homo sapiens
BTYAAGTGGN

NCCACTTRAV
SELEX
Yin et al.(2017)
NKX2-5_FL_Methyl-HT-SELEX_1
0.742 0.789
NKX2-5
M05348_2.00
Homo sapiens
BTYAACGAB

VTCGTTRAV
SELEX
Yin et al.(2017)
NKX2-5_FL_Methyl-HT-SELEX_2
0.742 0.789
NKX2-5
M00322_2.00
Homo sapiens
NNNRNNN

NNNYNNN
PBM
Barrera et al.(2016)
NKX2-5_R190C
0.742 0.772
NKX2-5
M00324_2.00
Homo sapiens
NHNNNNN

NNNNNDN
PBM
Barrera et al.(2016)
NKX2-5_T178M
0.742 0.772
Nkx2-3
M00497_2.00
Mus musculus
NNRAGDRNN

NNYHCTYNN
PBM
Berger et al.(2008)
Nkx2-3_3435
0.741 0.807
NKX2-3
M05042_2.00
Homo sapiens
NNBAAGTGBN

NVCACTTVNN
SELEX
Yin et al.(2017)
NKX2-3_eDBD_HT-SELEX
0.741 0.807
NKX2-3
M05045_2.00
Homo sapiens
BNBAAGTGBN

NVCACTTVNV
SELEX
Yin et al.(2017)
NKX2-3_FL_HT-SELEX
0.741 0.807
NKX2-3
M05043_2.00
Homo sapiens
BNBAAGTGBN

NVCACTTVNV
SELEX
Yin et al.(2017)
NKX2-3_eDBD_Methyl-HT-SELEX_1
0.741 0.807
NKX2-3
M05044_2.00
Homo sapiens
SDYAACGHB

VDCGTTRHS
SELEX
Yin et al.(2017)
NKX2-3_eDBD_Methyl-HT-SELEX_2
0.741 0.807
NKX2-3
M05046_2.00
Homo sapiens
BNBAAGTGBN

NVCACTTVNV
SELEX
Yin et al.(2017)
NKX2-3_FL_Methyl-HT-SELEX_1
0.741 0.807
NKX2-3
M05047_2.00
Homo sapiens
SWYAACSHB

VDSGTTRWS
SELEX
Yin et al.(2017)
NKX2-3_FL_Methyl-HT-SELEX_2
0.741 0.807
NKX2-5
M00321_2.00
Homo sapiens
HNAAGTRBNN

NNVYACTTND
PBM
Barrera et al.(2016)
NKX2-5_R161P
0.737 0.772
ceh-28
M08210_2.00
Caenorhabditis elegans
AATCGATW

WATCGATT
ChIP-seq
Contrino et al.(2012)
Mw138
0.736 0.649
Nkx2-6
M00496_2.00
Mus musculus
HYAAGTRBNN

NNVYACTTRD
PBM
Berger et al.(2008)
Nkx2-6_3437
0.718 0.754
tin
M00559_2.00
Drosophila melanogaster
NWYAAGTGGNN

NNCCACTTRWN
PBM
Busser et al.(2012a)
Tin
0.718 0.632
tin
M03809_2.00
Drosophila melanogaster
BTYAAGTGSN

NSCACTTRAV
SELEX
Nitta et al.(2015)
tin_1
0.718 0.632
tin
M06284_2.00
Drosophila melanogaster
BTYAAGTG

CACTTRAV
B1H
Zhu et al.(2011)
Tin_Cell_FBgn0004110
0.718 0.632
tin
M06285_2.00
Drosophila melanogaster
BCTCAAGTGSVN

NBSCACTTGAGV
B1H
Zhu et al.(2011)
tin_FlyReg_FBgn0004110
0.718 0.632
tin
M06286_2.00
Drosophila melanogaster
BWYAAGTR

YACTTRWV
B1H
Zhu et al.(2011)
Tin_SOLEXA_FBgn0004110
0.718 0.632
tin
M08421_2.00
Drosophila melanogaster
DBTCRAGTGS

SCACTYGAVH
ChIP-chip
Mathelier et al.(2014)
MA0247.2
0.718 0.632
NKX2-5
M00320_2.00
Homo sapiens
NHBAAKWRN

NYWMTTVDN
PBM
Barrera et al.(2016)
NKX2-5_K183E
0.709 0.772
Q24782_9CNID
M02206_2.00
Eleutheria dichotoma
TTAATTAA

TTAATTAA
PBM
Weirauch et al.(2014)
pTH5486
0.613 0.491
For this family, TFs with SR scores > 0.599 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000366347 Homeodomain 129 185

Links

Other Homeodomain family TFs
Other Homo sapiens TFs

821 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
27996.m000153 Ricinus communis 27996.m000153 N 0.000
Al_scaffold_0004_1965 Arabidopsis lyrata Al_scaffold_0004_1965 N 0.000
AMTR_s00011p00235740 Amborella trichopoda AMTR_s00011p00235740 N 0.000
Aquca_003_00697 Aquilegia coerulea Aquca_003_00697 N 0.000
Aquca_020_00213 Aquilegia coerulea Aquca_020_00213 N 0.000
BHLH52 Arabidopsis thaliana AT1G30670 N 0.000
BHLH53 Arabidopsis thaliana AT2G34820 N 0.000
Bo3g028090 Brassica oleracea Bo3g028090 N 0.000
Bo4g039270 Brassica oleracea Bo4g039270 N 0.000
Bostr.15697s0367 Boechera stricta Bostr.15697s0367 N 0.000
Bostr.23794s0621 Boechera stricta Bostr.23794s0621 N 0.000
Bra005389 Brassica rapa Bra005389 N 0.000
Bra022993 Brassica rapa Bra022993 N 0.000
Cagra.1508s0136 Capsella grandiflora Cagra.1508s0136 N 0.000
Carubv10011063m.g Capsella rubella Carubv10011063m.g N 0.000
cassava27522.m1 Manihot esculenta cassava27522.m1 N 0.000
cassava8426.m1 Manihot esculenta cassava8426.m1 N 0.000
Ca_13608 Cicer arietinum Ca_13608 N 0.000
Ca_13610 Cicer arietinum Ca_13610 N 0.000
Ciclev10017579m.g Citrus clementina Ciclev10017579m.g N 0.000
Cla020055 Citrullus lanatus Cla020055 N 0.000
Cucsa.167440 Cucumis sativus Cucsa.167440 N 0.000
Eucgr.D01630 Eucalyptus grandis Eucgr.D01630 N 0.000
evm.TU.supercontig_489.5 Carica papaya evm.TU.supercontig_489.5 N 0.000
evm.TU.supercontig_489.6 Carica papaya evm.TU.supercontig_489.6 N 0.000
fgenesh1_pm.C_scaffold_1002485 Arabidopsis lyrata fgenesh1_pm.C_scaffold_1002485 N 0.000
gene18542-v1.0-hybrid Fragaria vesca gene18542-v1.0-hybrid N 0.000
gene20146-v1.0-hybrid Fragaria vesca gene20146-v1.0-hybrid N 0.000
GLYMA08G17747 Glycine max GLYMA08G17747 N 0.000
GLYMA15G41400 Glycine max GLYMA15G41400 N 0.000
Gorai.002G107000 Gossypium raimondii Gorai.002G107000 N 0.000
Gorai.005G218900 Gossypium raimondii Gorai.005G218900 N 0.000
GSMUA_Achr11G16900_001 Musa acuminata GSMUA_Achr11G16900_001 N 0.000
GSMUA_AchrUn_randomG20690_001 Musa acuminata GSMUA_AchrUn_randomG20690_001 N 0.000
Lus10005451.g Linum usitatissimum Lus10005451.g N 0.000
Lus10038432.g Linum usitatissimum Lus10038432.g N 0.000
MDP0000209483 Malus domestica MDP0000209483 N 0.000
MDP0000216053 Malus domestica MDP0000216053 N 0.000
mgf020354m Mimulus guttatus mgf020354m N 0.000
MTR_1g060700 Medicago truncatula MTR_1g060700 N 0.000
MTR_2g067000 Medicago truncatula MTR_2g067000 N 0.000
orange1.1g041370m.g Citrus sinensis orange1.1g041370m.g N 0.000
PGSC0003DMG400020812 Solanum tuberosum PGSC0003DMG400020812 N 0.000
PGSC0003DMG400044874 Solanum tuberosum PGSC0003DMG400044874 N 0.000
Pm010610 Prunus mume Pm010610 N 0.000
POPTR_0001s46530 Populus trichocarpa POPTR_0001s46530 N 0.000
POPTR_0011s16100 Populus trichocarpa POPTR_0011s16100 N 0.000
PRUPE_ppa017597mg Prunus persica PRUPE_ppa017597mg N 0.000
PRUPE_ppa025945mg Prunus persica PRUPE_ppa025945mg N 0.000
SapurV1A.0527s0040 Salix purpurea SapurV1A.0527s0040 N 0.000
SapurV1A.0602s0120 Salix purpurea SapurV1A.0602s0120 N 0.000
Si038598m.g Setaria italica Si038598m.g N 0.000
Solyc08g075090.2 Solanum lycopersicum Solyc08g075090.2 N 0.000
Solyc08g075110.1 Solanum lycopersicum Solyc08g075110.1 N 0.000
TCM_027032 Theobroma cacao TCM_027032 N 0.000
TCM_033386 Theobroma cacao TCM_033386 N 0.000
Thhalv10009765m.g Eutrema salsugineum Thhalv10009765m.g N 0.000
Thhalv10017751m.g Eutrema salsugineum Thhalv10017751m.g N 0.000
VIT_10s0092g00030 Vitis vinifera VIT_10s0092g00030 N 0.000