CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
Home
Tools
View cart
Bulk downloads
Database stats
Contact us
Help
Update Log
FAQ
Links
How to cite
HLX
(
Homo sapiens
)
Homeodomain
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00046 (Homeobox)
IPR001356
ENSG00000136630
T209849_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including animal organ development; enteric nervous system development; and regulation of T-helper cell differentiation. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Hlx
M00485_2.00
Mus musculus
NNNAWND
HNWTNNN
PBM
Berger et al.(2008)
Hlx1_2350
0.867
1.000
H2.0
M06489_2.00
Drosophila melanogaster
WTWATDA
THATWAW
B1H
Mathelier et al.(2014)
MA0448.1
0.847
0.842
H2.0
M06250_2.00
Drosophila melanogaster
TWWWWDA
THAWWWA
B1H
Zhu et al.(2011)
H2.0_Cell_FBgn0001170
0.847
0.842
H2.0
M06251_2.00
Drosophila melanogaster
WTWATTRN
NYAATWAW
B1H
Zhu et al.(2011)
H2.0_SOLEXA_FBgn0001170
0.847
0.842
Dbx
M02128_2.00
Drosophila melanogaster
WTTAATTA
TAATTAAW
PBM
Weirauch et al.(2014)
pTH6051
0.733
0.719
Dbx
M06550_2.00
Drosophila melanogaster
TTWATKA
TMATWAA
B1H
Mathelier et al.(2014)
MA0174.1
0.733
0.719
Dbx1
M00451_2.00
Mus musculus
WTTAATTA
TAATTAAW
PBM
Berger et al.(2008)
Dbx1_3486
0.733
0.684
Dbx2
M00499_2.00
Mus musculus
NNDTNNN
NNNAHNN
PBM
Berger et al.(2008)
Dbx2_3487
0.713
0.632
For this family, TFs with SR scores >
0.599
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000355870
Homeodomain
277
333
SWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRH
ENSP00000408248
Homeodomain
10
66
SWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRH
Links
Other
Homeodomain
family TFs
Other
Homo sapiens
TFs
267 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy