CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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ZHX1
(
Homo sapiens
)
Homeodomain
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00046 (Homeobox)
IPR001356
ENSG00000165156
T209882_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 8 open reading frame 76 (C8orf76) gene. [provided by RefSeq, Feb 2011]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
ZHX1
M02093_2.00
Homo sapiens
NNDYBNNN
NNNVRHNN
PBM
Weirauch et al.(2014)
pTH5688
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
ZHX1
M02104_2.00
Tetraodon nigroviridis
TGRCGTRA
TYACGYCA
PBM
Weirauch et al.(2014)
pTH5897
0.614
0.667
For this family, TFs with SR scores >
0.599
will likely have a similar motif
Experimental Constructs
Motif ID
Domain
From
To
Sequence
M02093_2.00
Homeodomain
1
54
RAKKTKEQLAELKVSYLKNQFPHDSEIIRLMKITGLTKGEIKKWFSDTRYNQRN
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000297857
Homeodomain
297
339
PLLLNTYNKFPYPTMSEITVLSAQAKYTEEQIKIWFSAQRLKH
ENSP00000297857
Homeodomain
467
521
IRAKKTKEQLAELKVSYLKNQFPHDSEIIRLMKITGLTKGEIKKWFSDTRYNQRN
ENSP00000297857
Homeodomain
573
623
KEKTAEQLRVLQASFLNSSVLTDEELNRLRAQTKLTRREIDAWFTEKKKSK
ENSP00000297857
Homeodomain
665
717
CKKTPEQLHMLKSAFVRTQWPSPEEYDKLAKESGLARTDIVSWFGDTRYAWKN
ENSP00000297857
Homeodomain
779
825
KTGTAILKDYYLKHKFLNEQDLDELVNKSHMGYEQVREWFAERQRRS
ENSP00000378938
Homeodomain
297
339
PLLLNTYNKFPYPTMSEITVLSAQAKYTEEQIKIWFSAQRLKH
ENSP00000378938
Homeodomain
467
521
IRAKKTKEQLAELKVSYLKNQFPHDSEIIRLMKITGLTKGEIKKWFSDTRYNQRN
ENSP00000378938
Homeodomain
573
623
KEKTAEQLRVLQASFLNSSVLTDEELNRLRAQTKLTRREIDAWFTEKKKSK
ENSP00000378938
Homeodomain
665
717
CKKTPEQLHMLKSAFVRTQWPSPEEYDKLAKESGLARTDIVSWFGDTRYAWKN
ENSP00000378938
Homeodomain
779
825
KTGTAILKDYYLKHKFLNEQDLDELVNKSHMGYEQVREWFAERQRRS
ENSP00000428821
Homeodomain
468
521
RAKKTKEQLAELKVSYLKNQFPHDSEIIRLMKITGLTKGEIKKWFSDTRYNQRN
Links
Other
Homeodomain
family TFs
Other
Homo sapiens
TFs
57 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy