ZHX1 (Homo sapiens)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox) IPR001356 ENSG00000165156 T209882_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 8 open reading frame 76 (C8orf76) gene. [provided by RefSeq, Feb 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ZHX1
M02093_2.00		 Homo sapiens
NNDYBNNN
NNNVRHNN		 PBM
Weirauch et al.(2014)
pTH5688		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ZHX1
M02104_2.00 		Tetraodon nigroviridis
TGRCGTRA
TYACGYCA		 PBM
Weirauch et al.(2014)
pTH5897 		0.614 0.667
For this family, TFs with SR scores > 0.599 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M02093_2.00 Homeodomain 1 54

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000297857 Homeodomain 297 339
ENSP00000297857 Homeodomain 467 521
ENSP00000297857 Homeodomain 573 623
ENSP00000297857 Homeodomain 665 717
ENSP00000297857 Homeodomain 779 825
ENSP00000378938 Homeodomain 297 339
ENSP00000378938 Homeodomain 467 521
ENSP00000378938 Homeodomain 573 623
ENSP00000378938 Homeodomain 665 717
ENSP00000378938 Homeodomain 779 825
ENSP00000428821 Homeodomain 468 521

Links

Other Homeodomain family TFs
Other Homo sapiens TFs

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57 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action