NKX2-5 (Homo sapiens)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox) IPR001356 ENSG00000183072 T209925_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
NKX2-5
M00320_2.00
Homo sapiens
NHBAAKWRN

NYWMTTVDN
PBM
Barrera et al.(2016)
NKX2-5_K183E
(Direct) (Direct)
NKX2-5
M00321_2.00
Homo sapiens
HNAAGTRBNN

NNVYACTTND
PBM
Barrera et al.(2016)
NKX2-5_R161P
(Direct) (Direct)
NKX2-5
M00322_2.00
Homo sapiens
NNNRNNN

NNNYNNN
PBM
Barrera et al.(2016)
NKX2-5_R190C
(Direct) (Direct)
NKX2-5
M00323_2.00
Homo sapiens
NWYAAGTGSNN

NNSCACTTRWN
PBM
Barrera et al.(2016)
NKX2-5_REF
(Direct) (Direct)
NKX2-5
M00324_2.00
Homo sapiens
NHNNNNN

NNNNNDN
PBM
Barrera et al.(2016)
NKX2-5_T178M
(Direct) (Direct)
NKX2-5
M01507_2.00
Homo sapiens
NNRAGWR

YWCTYNN
PBM
Yin et al.(2017b)
NKX2.5_5mCG
(Direct) (Direct)
NKX2-5
M01508_2.00
Homo sapiens
NNDAGWR

YWCTHNN
PBM
Yin et al.(2017b)
NKX2.5_Cytosine
(Direct) (Direct)
NKX2-5
M05346_2.00
Homo sapiens
BHYAAGTGBN

NVCACTTRDV
SELEX
Yin et al.(2017)
NKX2-5_FL_HT-SELEX
(Direct) (Direct)
NKX2-5
M05347_2.00
Homo sapiens
BTYAAGTGGN

NCCACTTRAV
SELEX
Yin et al.(2017)
NKX2-5_FL_Methyl-HT-SELEX_1
(Direct) (Direct)
NKX2-5
M05348_2.00
Homo sapiens
BTYAACGAB

VTCGTTRAV
SELEX
Yin et al.(2017)
NKX2-5_FL_Methyl-HT-SELEX_2
(Direct) (Direct)
NKX2-5
M09163_2.00
Homo sapiens
BKRAGWGV

BCWCTYMV
Misc
Kulakovskiy et al.(2013)
NKX25_HUMAN.H11MO.0.B
(Direct) (Direct)
NKX2-5
M10742_2.00
Homo sapiens
TYAAGTG

CACTTRA
Transfac
Matys et al.(2006)
V$NKX25_01
(Direct) (Direct)
NKX2-5
M10743_2.00
Homo sapiens
CWTAATTV

BAATTAWG
Transfac
Matys et al.(2006)
V$NKX25_02
(Direct) (Direct)
NKX2-5
M10744_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NKX25_Q5
(Direct) (Direct)
NKX2-5
M10745_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NKX25_Q6
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Nkx2-5
M00404_2.00
Mus musculus
NNNRAGDRBN

NVYHCTYNNN
PBM
Berger et al.(2008)
Nkx2-5_3436
0.867 1.000
Nkx2-5
M02686_2.00
Mus musculus
WTAAKWK

MWMTTAW
SELEX
Mathelier et al.(2014)
MA0063.1
0.867 1.000
Nkx2-5
M08136_2.00
Mus musculus
SYTGAGWGSYH

DRSCWCTCARS
ChIP-seq
Mathelier et al.(2014)
MA0503.1
0.867 1.000
Nkx2-5
M09177_2.00
Mus musculus
NBYBRAGTGS

SCACTYVRVN
Misc
Kulakovskiy et al.(2013)
NKX25_MOUSE.H11MO.0.A
0.867 1.000
Nkx2-5
M09567_2.00
Mus musculus
HBRAGWGBNN

NNVCWCTYVD
Misc
Heinz et al.(2010)
HL1-Nkx2.5.biotin_GSE21529
0.867 1.000
Nkx2-3
M00497_2.00
Mus musculus
NNRAGDRNN

NNYHCTYNN
PBM
Berger et al.(2008)
Nkx2-3_3435
0.853 0.930
NKX2-3
M05042_2.00
Homo sapiens
NNBAAGTGBN

NVCACTTVNN
SELEX
Yin et al.(2017)
NKX2-3_eDBD_HT-SELEX
0.853 0.930
NKX2-3
M05045_2.00
Homo sapiens
BNBAAGTGBN

NVCACTTVNV
SELEX
Yin et al.(2017)
NKX2-3_FL_HT-SELEX
0.853 0.930
NKX2-3
M05043_2.00
Homo sapiens
BNBAAGTGBN

NVCACTTVNV
SELEX
Yin et al.(2017)
NKX2-3_eDBD_Methyl-HT-SELEX_1
0.853 0.930
NKX2-3
M05044_2.00
Homo sapiens
SDYAACGHB

VDCGTTRHS
SELEX
Yin et al.(2017)
NKX2-3_eDBD_Methyl-HT-SELEX_2
0.853 0.930
NKX2-3
M05046_2.00
Homo sapiens
BNBAAGTGBN

NVCACTTVNV
SELEX
Yin et al.(2017)
NKX2-3_FL_Methyl-HT-SELEX_1
0.853 0.930
NKX2-3
M05047_2.00
Homo sapiens
SWYAACSHB

VDSGTTRWS
SELEX
Yin et al.(2017)
NKX2-3_FL_Methyl-HT-SELEX_2
0.853 0.930
ceh-28
M08210_2.00
Caenorhabditis elegans
AATCGATW

WATCGATT
ChIP-seq
Contrino et al.(2012)
Mw138
0.826 0.754
scro
M03854_2.00
Drosophila melanogaster
NNBRMGTGB

VCACKYVNN
SELEX
Nitta et al.(2015)
scro_1
0.808 0.842
Nkx2-6
M00496_2.00
Mus musculus
HYAAGTRBNN

NNVYACTTRD
PBM
Berger et al.(2008)
Nkx2-6_3437
0.805 0.825
ceh-24
M02181_2.00
Caenorhabditis elegans
NNRAKWRNN

NNYWMTYNN
PBM
Weirauch et al.(2014)
pTH6327
0.803 0.807
tin
M00559_2.00
Drosophila melanogaster
NWYAAGTGGNN

NNCCACTTRWN
PBM
Busser et al.(2012a)
Tin
0.790 0.684
tin
M03809_2.00
Drosophila melanogaster
BTYAAGTGSN

NSCACTTRAV
SELEX
Nitta et al.(2015)
tin_1
0.790 0.684
tin
M06284_2.00
Drosophila melanogaster
BTYAAGTG

CACTTRAV
B1H
Zhu et al.(2011)
Tin_Cell_FBgn0004110
0.790 0.684
tin
M06285_2.00
Drosophila melanogaster
BCTCAAGTGSVN

NBSCACTTGAGV
B1H
Zhu et al.(2011)
tin_FlyReg_FBgn0004110
0.790 0.684
tin
M06286_2.00
Drosophila melanogaster
BWYAAGTR

YACTTRWV
B1H
Zhu et al.(2011)
Tin_SOLEXA_FBgn0004110
0.790 0.684
tin
M08421_2.00
Drosophila melanogaster
DBTCRAGTGS

SCACTYGAVH
ChIP-chip
Mathelier et al.(2014)
MA0247.2
0.790 0.684
Nkx2-1
M00385_2.00
Mus musculus
NNRAGDRN

NYHCTYNN
PBM
Berger et al.(2008)
Titf1_1722
0.787 0.825
Nkx2-4
M00514_2.00
Mus musculus
NNRAGDRBNN

NNVYHCTYNN
PBM
Berger et al.(2008)
Nkx2-4_3074
0.787 0.825
NKX2-1
M09146_2.00
Homo sapiens
BTKGAGWGBN

NVCWCTCMAV
Misc
Kulakovskiy et al.(2013)
NKX21_HUMAN.H11MO.0.A
0.787 0.825
Nkx2-1
M09171_2.00
Mus musculus
NBTKGAGWGB

VCWCTCMAVN
Misc
Kulakovskiy et al.(2013)
NKX21_MOUSE.H11MO.0.A
0.787 0.825
Nkx2-1
M09563_2.00
Mus musculus
BTBRAGWGBH

DVCWCTYVAV
Misc
Heinz et al.(2010)
LungAC-Nkx2.1_GSE43252
0.787 0.825
NKX2-1
M10694_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TITF1_Q3
0.787 0.825
NKX2-1
M10695_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TTF1_Q5_01
0.787 0.825
NKX2-1
M10696_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TTF1_Q5
0.787 0.825
NKX2-1
M10697_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TTF1_Q6
0.787 0.825
Nkx2-9
M00520_2.00
Mus musculus
NNNRAGDRBN

NVYHCTYNNN
PBM
Berger et al.(2008)
Nkx2-9_3082
0.747 0.789
Nkx2-9
M00800_2.00
Mus musculus
NNRAGDRBNN

NNVYHCTYNN
PBM
Weirauch et al.(2013)
pTH2842
0.747 0.789
Nkx2-9
M09215_2.00
Mus musculus
BTCAAGKRB

VYMCTTGAV
Misc
Kulakovskiy et al.(2013)
NKX28_MOUSE.H11MO.0.C
0.747 0.789
Nkx2-2
M00438_2.00
Mus musculus
NNNRAGDRN

NYHCTYNNN
PBM
Berger et al.(2008)
Nkx2-2_2823
0.742 0.789
Nkx2-2
M09190_2.00
Mus musculus
NTBRAGWGBBN

NVVCWCTYVAN
Misc
Kulakovskiy et al.(2013)
NKX22_MOUSE.H11MO.0.A
0.742 0.789
NKX2-2
M10681_2.00
Homo sapiens
WTAAGTRBTT

AAVYACTTAW
Transfac
Matys et al.(2006)
V$NKX22_01
0.742 0.789
NKX2-2
M10682_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NKX2B_Q3_01
0.742 0.789
NKX2-2
M10683_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NKX2B_Q3
0.742 0.789
vnd
M06551_2.00
Drosophila melanogaster
WYTCAAGTR

YACTTGARW
B1H
Mathelier et al.(2014)
MA0253.1
0.742 0.772
vnd
M06377_2.00
Drosophila melanogaster
WYTCAAGTR

YACTTGARW
B1H
Zhu et al.(2011)
Vnd_Cell_FBgn0003986
0.742 0.772
vnd
M06378_2.00
Drosophila melanogaster
KYTSAAGWGY

RCWCTTSARM
B1H
Zhu et al.(2011)
vnd_FlyReg_FBgn0003986
0.742 0.772
vnd
M06379_2.00
Drosophila melanogaster
BTBAAGTR

YACTTVAV
B1H
Zhu et al.(2011)
Vnd_SOLEXA_FBgn0003986
0.742 0.772
vnd
M09683_2.00
Drosophila melanogaster
TCAAGTGB

VCACTTGA
Misc
Kulakovskiy et al.(2009)
vnd
0.742 0.772
NKX2-8
M00302_2.00
Homo sapiens
NNRAGDRB

VYHCTYNN
PBM
Barrera et al.(2016)
NKX2-8_REF
0.715 0.789
NKX2-8
M05149_2.00
Homo sapiens
BTSRAGTGBN

NVCACTYSAV
SELEX
Yin et al.(2017)
NKX2-8_FL_HT-SELEX
0.715 0.789
NKX2-8
M09145_2.00
Homo sapiens
BTCAAGKRB

VYMCTTGAV
Misc
Kulakovskiy et al.(2013)
NKX28_HUMAN.H11MO.0.C
0.715 0.789
NKX2-8
M05150_2.00
Homo sapiens
GCARTAACGACATC

GATGTCGTTAYTGC
SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_1
0.715 0.789
NKX2-8
M05151_2.00
Homo sapiens
BTSAAGTGBN

NVCACTTSAV
SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_2
0.715 0.789
NKX2-8
M05152_2.00
Homo sapiens
BTBAACGAB

VTCGTTVAV
SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_3
0.715 0.789
NKX2-8
M00301_2.00
Homo sapiens
NNRAKDRB

VYHMTYNN
PBM
Barrera et al.(2016)
NKX2-8_A94T
0.715 0.772
ceh-22
M00376_2.00
Caenorhabditis elegans
WBRAGTRBNN

NNVYACTYVW
PBM
Berger et al.(2006)
Ceh-22
0.711 0.702
Q24782_9CNID
M02206_2.00
Eleutheria dichotoma
TTAATTAA

TTAATTAA
PBM
Weirauch et al.(2014)
pTH5486
0.623 0.544
Q70LF3_ARTSF
M02211_2.00
Artemia franciscana
BTAATTAB

VTAATTAV
PBM
Weirauch et al.(2014)
pTH5553
0.599 0.439
For this family, TFs with SR scores > 0.599 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00320_2.00 Homeodomain 15 71
M00321_2.00 Homeodomain 15 71
M00322_2.00 Homeodomain 15 71
M00323_2.00 Homeodomain 15 71
M00324_2.00 Homeodomain 15 71
M01507_2.00 Homeodomain 28 84
M01508_2.00 Homeodomain 28 84

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000327758 Homeodomain 139 195

Links

Other Homeodomain family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

823 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action