POU6F1 (Homo sapiens)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00157 (Pou) IPR000327 ENSG00000184271 T209926_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in actin cytoskeleton and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
POU6F1
M02094_2.00		 Homo sapiens
VNTAATTANB
VNTAATTANB		 PBM
Weirauch et al.(2014)
pTH6519		 (Direct) (Direct)
POU6F1
M05349_2.00		 Homo sapiens
NATTATGNNNNVSATAATN
NATTATSBNNNNCATAATN		 SELEX
Yin et al.(2017)
POU6F1_FL_HT-SELEX_1		 (Direct) (Direct)
POU6F1
M05350_2.00		 Homo sapiens
NTAATKABRTRBNN
NNVYAYVTMATTAN		 SELEX
Yin et al.(2017)
POU6F1_FL_HT-SELEX_2		 (Direct) (Direct)
POU6F1
M05351_2.00		 Homo sapiens
DTAATGAKNN
NNMTCATTAH		 SELEX
Yin et al.(2017)
POU6F1_FL_HT-SELEX_3		 (Direct) (Direct)
POU6F1
M05352_2.00		 Homo sapiens
TATGCNNNGCATA
TATGCNNNGCATA		 SELEX
Yin et al.(2017)
POU6F1_FL_HT-SELEX_4		 (Direct) (Direct)
POU6F1
M05353_2.00		 Homo sapiens
NTAATGAKATGCRN
NYGCATMTCATTAN		 SELEX
Yin et al.(2017)
POU6F1_FL_Methyl-HT-SELEX_1		 (Direct) (Direct)
POU6F1
M05354_2.00		 Homo sapiens
DTAATGAGVD
HBCTCATTAH		 SELEX
Yin et al.(2017)
POU6F1_FL_Methyl-HT-SELEX_2		 (Direct) (Direct)
POU6F1
M05355_2.00		 Homo sapiens
DTATGHTAATKAKN
NMTMATTADCATAH		 SELEX
Yin et al.(2017)
POU6F1_FL_Methyl-HT-SELEX_3		 (Direct) (Direct)
POU6F1
M05356_2.00		 Homo sapiens
TAATKAKNNNTAATKA
TMATTANNNMTMATTA		 SELEX
Yin et al.(2017)
POU6F1_FL_Methyl-HT-SELEX_4		 (Direct) (Direct)
POU6F1
M10746_2.00		 Homo sapiens
GCATAAWTTAT
ATAAWTTATGC		 Transfac
Matys et al.(2006)
V$POU6F1_01		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
pdm3
M02127_2.00 		Drosophila melanogaster
CTAATTAN
NTAATTAG		 PBM
Weirauch et al.(2014)
pTH6769 		0.703 0.684
Pou1f1
M02238_2.00 		Mus musculus
NTAATKHNN
NNDMATTAN		 PBM
Weirauch et al.(2014)
pTH6507 		0.637 0.526
For this family, TFs with SR scores > 0.599 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M02094_2.00 Homeodomain 1 57

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000330190 POU 142 213
ENSP00000330190 Homeodomain 235 291
ENSP00000373895 POU 142 213
ENSP00000373895 Homeodomain 235 291
ENSP00000448389 Homeodomain 235 291

Links

Other Homeodomain family TFs
Other Homo sapiens TFs

48 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
POU6F1 Gorilla gorilla ENSGGOG00000000227 I 1.000
POU6F1 Loxodonta africana ENSLAFG00000020901 I 1.000
ENSMEUG00000001957 Macropus eugenii ENSMEUG00000001957 I 1.000
ENSMICG00000009560 Microcebus murinus ENSMICG00000009560 I 1.000
POU6F1 Felis catus ENSFCAG00000004408 I 1.000
ENSETEG00000018248 Echinops telfairi ENSETEG00000018248 I 1.000
POU6F1 Dasypus novemcinctus ENSDNOG00000009291 I 1.000
ENSDORG00000014216 Dipodomys ordii ENSDORG00000014216 I 1.000
POU6F1 Equus caballus ENSECAG00000024200 I 1.000
POU6F1 Erinaceus europaeus ENSEEUG00000014085 I 1.000
ENSMMUG00000001139 Macaca mulatta ENSMMUG00000001139 I 1.000
POU6F1 Monodelphis domestica ENSMODG00000018676 I 1.000
POU6F1 Sorex araneus ENSSARG00000003778 I 1.000
ENSSTOG00000009140 Ictidomys tridecemlineatus ENSSTOG00000009140 I 1.000
POU6F1 Tursiops truncatus ENSTTRG00000013841 I 1.000
ENSP00000373895 Macaca fascicularis ENSP00000373895 I 1.000
Pou6f1 Rattus norvegicus ENSRNOG00000004595 I 1.000
POU6F1 Pan troglodytes ENSPTRG00000004950 I 1.000
ENSMPUG00000007990 Mustela putorius furo ENSMPUG00000007990 I 1.000
ENSNLEG00000017777 Nomascus leucogenys ENSNLEG00000017777 I 1.000
POU6F1 Otolemur garnettii ENSOGAG00000007973 I 1.000
ENSPPYG00000004523 Pongo abelii ENSPPYG00000004523 I 1.000
ENSCSAG00000005904 Chlorocebus sabaeus ENSCSAG00000005904 I 1.000
POU6F1 Callithrix jacchus ENSCJAG00000017646 I 1.000
ENSAMEG00000002092 Ailuropoda melanoleuca ENSAMEG00000002092 I 1.000
POU6F1 Canis familiaris ENSCAFG00000007790 I 1.000
CPIJ003414 Culex quinquefasciatus CPIJ003414 I 0.703
ACUA020432 Anopheles culicifacies ACUA020432 I 0.703
CpipJ_CPIJ003414 Culex pipiens CpipJ_CPIJ003414 I 0.703
pdm3 Drosophila melanogaster FBgn0261588 D 0.703
ACYPI27690 Acyrthosiphon pisum ACYPI27690 I 0.703
BGIBMGA005254 Bombyx mori BGIBMGA005254 I 0.703
SPER_0000448001 Spirometra erinaceieuropaei SPER_0000448001 I 0.657
MESCA009897 Megaselia scalaris MESCA009897 I 0.635
SBAD_0000673901 Soboliphyme baturini SBAD_0000673901 I 0.635
BXY_0883500 Bursaphelenchus xylophilus BXY_0883500 I 0.625
ENSCING00000013609 Ciona intestinalis ENSCING00000013609 I 0.624
ENSCSAVG00000007148 Ciona savignyi ENSCSAVG00000007148 I 0.624
ENSSHAG00000018562 Sarcophilus harrisii ENSSHAG00000018562 I 0.621
BGIBMGA010300 Bombyx mori BGIBMGA010300 I 0.621
POU2F2 Homo sapiens ENSG00000028277 D 0.621
AMAM009961 Anopheles maculatus AMAM009961 I 0.616
HelroG138303 Helobdella robusta HelroG138303 I 0.616
SMTD_0002076601 Schistosoma mattheei SMTD_0002076601 I 0.603
GPUH_0000951201 Gongylonema pulchrum GPUH_0000951201 I 0.603
SROB_0001854701 Schistosoma rodhaini SROB_0001854701 I 0.603
L596_g13343 Steinernema carpocapsae L596_g13343 I 0.599