TF Information

Hoxd13 *(Mus musculus)* Homeodomain
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00046 (Homeobox)	IPR001356	ENSMUSG00000001819	T212395_2.00	Ensembl (2018-Dec-8)	Link out
NCBI Gene Info: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within several processes, including male genitalia development; morphogenesis of an epithelium; and regulation of branching involved in prostate gland morphogenesis. Located in nucleus. Is expressed in several structures, including genitourinary system; hindgut; limb; limb bud; and tail. Used to study synpolydactyly. Human ortholog(s) of this gene implicated in brachydactyly-syndactyly syndrome; clubfoot; cryptorchidism; and dysostosis (multiple). Orthologous to human HOXD13 (homeobox D13). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
Hoxd13 M00394_2.00	Mus musculus	NWTHRYDDN	NHHRYDAWN	PBM Berger et al.(2008) Hoxd13_2356	(Direct)	(Direct)
Hoxd13 M03247_2.00	Mus musculus	DKTTTATTRS	SYAATAAAMH	SELEX Jolma et al.(2013) Hoxd13_1	(Direct)	(Direct)
Hoxd13 M03248_2.00	Mus musculus	DDTTTAYKAGN	NCTMRTAAAHH	SELEX Jolma et al.(2013) Hoxd13_2	(Direct)	(Direct)
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
HOXD13 M00299_2.00	Homo sapiens	NTTWAYDDN	NHHRTWAAN	PBM Barrera et al.(2016) HOXD13_REF	0.867	1.000
HOXD13 M03141_2.00	Homo sapiens	DTTTTATKRS	SYMATAAAAH	SELEX Jolma et al.(2013) HOXD13_1	0.867	1.000
HOXD13 M03142_2.00	Homo sapiens	BCTCGTAAAAH	DTTTTACGAGV	SELEX Jolma et al.(2013) HOXD13_2	0.867	1.000
HOXD13 M05122_2.00	Homo sapiens	GKTTTATKGSS	SSCMATAAAMC	SELEX Yin et al.(2017) HOXD13_eDBD_HT-SELEX_1	0.867	1.000
HOXD13 M05123_2.00	Homo sapiens	BCTCGTAAAMH	DKTTTACGAGV	SELEX Yin et al.(2017) HOXD13_eDBD_HT-SELEX_2	0.867	1.000
HOXD13 M10689_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$HOXD13_Q6	0.867	1.000
HOXD13 M05124_2.00	Homo sapiens	DDTTTATTRBB	VVYAATAAAHH	SELEX Yin et al.(2017) HOXD13_eDBD_Methyl-HT-SELEX_1	0.867	1.000
HOXD13 M05125_2.00	Homo sapiens	VCTCGTAAAAH	DTTTTACGAGB	SELEX Yin et al.(2017) HOXD13_eDBD_Methyl-HT-SELEX_2	0.867	1.000
HOXD13 M00295_2.00	Homo sapiens	NTTWAYDDN	NHHRTWAAN	PBM Barrera et al.(2016) HOXD13_N298S	0.867	0.982
HOXD13 M00300_2.00	Homo sapiens	WTTTATDR	YHATAAAW	PBM Barrera et al.(2016) HOXD13_S316C	0.867	0.982
HOXD13 M00293_2.00	Homo sapiens	NTTWAYDDNN	NNHHRTWAAN	PBM Barrera et al.(2016) HOXD13_I297V	0.866	0.982
HOXD13 M00298_2.00	Homo sapiens	NTTWAYDDN	NHHRTWAAN	PBM Barrera et al.(2016) HOXD13_R306W	0.859	0.982
HOXD13 M00294_2.00	Homo sapiens	THGTWAAW	WTTWACDA	PBM Barrera et al.(2016) HOXD13_I322L	0.849	0.982
hoxd13a M02081_2.00	Danio rerio	WTTTATDR	YHATAAAW	PBM Weirauch et al.(2014) pTH6143	0.848	0.807
Hoxa13 M00473_2.00	Mus musculus	NTTWAYDRN	NYHRTWAAN	PBM Berger et al.(2008) Hoxa13_3126	0.834	0.895
HOXA13 M03098_2.00	Homo sapiens	DKTTTATKRS	SYMATAAAMH	SELEX Jolma et al.(2013) HOXA13_1	0.834	0.895
HOXA13 M03099_2.00	Homo sapiens	NCTCGTAAAHN	NDTTTACGAGN	SELEX Jolma et al.(2013) HOXA13_2	0.834	0.895
HOXA13 M03100_2.00	Homo sapiens	DKTTTATKRS	SYMATAAAMH	SELEX Jolma et al.(2013) HOXA13_3	0.834	0.895
HOXA13 M03101_2.00	Homo sapiens	NCTCGTAAAAH	DTTTTACGAGN	SELEX Jolma et al.(2013) HOXA13_4	0.834	0.895
HOXA13 M04977_2.00	Homo sapiens	DTTTTATKGGB	VCCMATAAAAH	SELEX Yin et al.(2017) HOXA13_eDBD_HT-SELEX_1	0.834	0.895
HOXA13 M04978_2.00	Homo sapiens	NCTCGTAAAHN	NDTTTACGAGN	SELEX Yin et al.(2017) HOXA13_eDBD_HT-SELEX_2	0.834	0.895
HOXA13 M04981_2.00	Homo sapiens	DTTTTATKRSN	NSYMATAAAAH	SELEX Yin et al.(2017) HOXA13_FL_HT-SELEX_1	0.834	0.895
HOXA13 M04982_2.00	Homo sapiens	NCTCGTAAAWH	DWTTTACGAGN	SELEX Yin et al.(2017) HOXA13_FL_HT-SELEX_2	0.834	0.895
HOXA13 M09134_2.00	Homo sapiens	VDTWTWATKGS	SCMATWAWAHB	Misc Kulakovskiy et al.(2013) HXA13_HUMAN.H11MO.0.C	0.834	0.895
Hoxa13 M09202_2.00	Mus musculus	VDTWTWATKGS	SCMATWAWAHB	Misc Kulakovskiy et al.(2013) HXA13_MOUSE.H11MO.0.C	0.834	0.895
HOXA13 M10653_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$HOXA13_01	0.834	0.895
HOXA13 M10654_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$HOXA13_02	0.834	0.895
HOXA13 M04979_2.00	Homo sapiens	DTTTTATTRSN	NSYAATAAAAH	SELEX Yin et al.(2017) HOXA13_eDBD_Methyl-HT-SELEX_1	0.834	0.895
HOXA13 M04980_2.00	Homo sapiens	NCTCGTAAAHN	NDTTTACGAGN	SELEX Yin et al.(2017) HOXA13_eDBD_Methyl-HT-SELEX_2	0.834	0.895
HOXA13 M04983_2.00	Homo sapiens	DKTTTATTGBN	NVCAATAAAMH	SELEX Yin et al.(2017) HOXA13_FL_Methyl-HT-SELEX_1	0.834	0.895
HOXA13 M04984_2.00	Homo sapiens	NCTCGTAAAWH	DWTTTACGAGN	SELEX Yin et al.(2017) HOXA13_FL_Methyl-HT-SELEX_2	0.834	0.895
Hoxc13 M00389_2.00	Mus musculus	NTTWAYDRNN	NNYHRTWAAN	PBM Berger et al.(2008) Hoxc13_3127	0.834	0.860
HOXC13 M03129_2.00	Homo sapiens	NTTTTATTRS	SYAATAAAAN	SELEX Jolma et al.(2013) HOXC13_1	0.834	0.860
HOXC13 M03130_2.00	Homo sapiens	NCTCGTAAAAH	DTTTTACGAGN	SELEX Jolma et al.(2013) HOXC13_2	0.834	0.860
HOXC13 M05072_2.00	Homo sapiens	RKTTTATKGSN	NSCMATAAAMY	SELEX Yin et al.(2017) HOXC13_eDBD_HT-SELEX_1	0.834	0.860
HOXC13 M05073_2.00	Homo sapiens	BCTCGTAAAMH	DKTTTACGAGV	SELEX Yin et al.(2017) HOXC13_eDBD_HT-SELEX_2	0.834	0.860
HOXC13 M10680_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$HOXC13_Q2	0.834	0.860
HOXC13 M05074_2.00	Homo sapiens	BCTCGTAAAAH	DTTTTACGAGV	SELEX Yin et al.(2017) HOXC13_eDBD_Methyl-HT-SELEX	0.834	0.860
HOXB13 M02092_2.00	Homo sapiens	NTTWAYDDNN	NNHHRTWAAN	PBM Weirauch et al.(2014) pTH5808	0.704	0.807
Hoxb13 M00505_2.00	Mus musculus	NTTWAYDDNN	NNHHRTWAAN	PBM Berger et al.(2008) Hoxb13_3479	0.704	0.807
HOXB13 M03175_2.00	Homo sapiens	DTTTTATKGG	CCMATAAAAH	SELEX Jolma et al.(2013) HOXB13_1	0.704	0.807
HOXB13 M03176_2.00	Homo sapiens	BCTCGTAAAAH	DTTTTACGAGV	SELEX Jolma et al.(2013) HOXB13_2	0.704	0.807
HOXB13 M05201_2.00	Homo sapiens	DTTTTATKGGN	NCCMATAAAAH	SELEX Yin et al.(2017) HOXB13_eDBD_HT-SELEX_1	0.704	0.807
HOXB13 M05202_2.00	Homo sapiens	NCTCGTAAAHH	DDTTTACGAGN	SELEX Yin et al.(2017) HOXB13_eDBD_HT-SELEX_2	0.704	0.807
HOXB13 M09149_2.00	Homo sapiens	TTTTATDRSN	NSYHATAAAA	Misc Kulakovskiy et al.(2013) HXB13_HUMAN.H11MO.0.A	0.704	0.807
HOXB13 M05203_2.00	Homo sapiens	NCTCGTAAAAH	DTTTTACGAGN	SELEX Yin et al.(2017) HOXB13_eDBD_Methyl-HT-SELEX	0.704	0.807
HOXD13 M00296_2.00	Homo sapiens	GKATAAAH	DTTTATMC	PBM Barrera et al.(2016) HOXD13_Q325K	0.633	0.982
HOXD13 M00297_2.00	Homo sapiens	NWTWRKNNNN	NNNNMYWAWN	PBM Barrera et al.(2016) HOXD13_Q325R	0.633	0.982
For this family, TFs with SR scores > 0.599* will likely have a similar motif*

Experimental Constructs

Motif ID	Domain	From	To	Sequence
M00394_2.00	Homeodomain	17	73	RKKRVPYTKLQLKELENEYAINKFINKDKRRRISAATNLSERQVTIWFQNRRVKDKK

DNA Binding Domains

Protein ID	Domain	From	To	Sequence
ENSMUSP00000001872	Homeodomain	273	329	RKKRVPYTKLQLKELENEYAINKFINKDKRRRISAATNLSERQVTIWFQNRRVKDKK

Links
Other Homeodomain family TFs
Other *Mus musculus* TFs

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266 Related TFs

Name	Species	Gene ID	Motif Evidence	SR Score	Action

Hoxd13 (Mus musculus) Homeodomain

TF Information

Directly determined binding motifs

Motifs from related TFs

Experimental Constructs

DNA Binding Domains

Links

266 Related TFs

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Hoxd13 **(Mus musculus)
Homeodomain**