CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Six6
(
Mus musculus
)
Homeodomain
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00046 (Homeobox)
IPR001356
ENSMUSG00000021099
T212416_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 12 and is thought to be involved in eye development. The encoded transcription factor regulates early progenitor cell proliferation during mammalian retinogenesis and pituitary development. Mice lacking this gene exhibit abnormal development of the suprachiasmatic nucleus and circadian rhythms. [provided by RefSeq, Sep 2015]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Six6
M00169_2.00
Mus musculus
NNAYMNN
NNKRTNN
PBM
Badis et al.(2009)
Six6_2267
(Direct)
(Direct)
Six6
M00412_2.00
Mus musculus
NNNTGATAYCN
NGRTATCANNN
PBM
Berger et al.(2008)
Six6_2267
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
SIX6
M00326_2.00
Homo sapiens
NNDATMB
VKATHNN
PBM
Barrera et al.(2016)
SIX6_REF
0.867
1.000
SIX6
M05357_2.00
Homo sapiens
NNYGATASVB
VBSTATCRNN
SELEX
Yin et al.(2017)
SIX6_eDBD_HT-SELEX
0.867
1.000
SIX6
M05358_2.00
Homo sapiens
VBVYAYCRNN
NNYGRTRBVB
SELEX
Yin et al.(2017)
SIX6_eDBD_Methyl-HT-SELEX
0.867
1.000
Six3
M00483_2.00
Mus musculus
NNNAYMN
NKRTNNN
PBM
Berger et al.(2008)
Six3_1732
0.865
0.982
SIX3
M05159_2.00
Homo sapiens
NNYGATABBN
NVVTATCRNN
SELEX
Yin et al.(2017)
SIX3_eDBD_HT-SELEX
0.865
0.982
SIX3
M10698_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SIX3_Q6
0.865
0.982
SIX6
M00325_2.00
Homo sapiens
NNNDATMB
VKATHNNN
PBM
Barrera et al.(2016)
SIX6_H141N
0.865
0.982
SIX3
M05160_2.00
Homo sapiens
NNYGATABVB
VBVTATCRNN
SELEX
Yin et al.(2017)
SIX3_eDBD_Methyl-HT-SELEX
0.865
0.982
six3
M02102_2.00
Oryzias latipes
NNDAYMBNNN
NNNVKRTHNN
PBM
Weirauch et al.(2014)
pTH5928
0.865
0.947
Optix
M02124_2.00
Drosophila melanogaster
NNNNNDATMN
NKATHNNNNN
PBM
Weirauch et al.(2014)
pTH5437
0.865
0.930
Optix
M03850_2.00
Drosophila melanogaster
TAATYTAATTA
TAATTARATTA
SELEX
Nitta et al.(2015)
Optix_1
0.865
0.930
Optix
M06526_2.00
Drosophila melanogaster
TGATA
TATCA
B1H
Mathelier et al.(2014)
MA0199.1
0.865
0.930
Optix
M06327_2.00
Drosophila melanogaster
HHVTGATA
TATCABDD
B1H
Zhu et al.(2011)
Optix_Cell_FBgn0025360
0.865
0.930
Optix
M06328_2.00
Drosophila melanogaster
NNNTGATA
TATCANNN
B1H
Zhu et al.(2011)
Optix_SOLEXA_FBgn0025360
0.865
0.930
SIX6
M00327_2.00
Homo sapiens
NHDAYMBNN
NNVKRTHDN
PBM
Barrera et al.(2016)
SIX6_T165A
0.860
0.982
For this family, TFs with SR scores >
0.599
will likely have a similar motif
Experimental Constructs
Motif ID
Domain
From
To
Sequence
M00169_2.00
Homeodomain
16
72
EQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRA
M00412_2.00
Homeodomain
16
72
EQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRA
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSMUSP00000021519
Homeodomain
129
185
EQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRA
Links
Other
Homeodomain
family TFs
Other
Mus musculus
TFs
296 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy