CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Irx4
(
Mus musculus
)
Homeodomain
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00046 (Homeobox)
IPR001356
ENSMUSG00000021604
T212421_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within heart development. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; heart; sensory organ; and skin. Orthologous to human IRX4 (iroquois homeobox 4). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Irx4
M00416_2.00
Mus musculus
NNNDAMAH
DTKTHNNN
PBM
Berger et al.(2008)
Irx4_2242
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Irx6
M00456_2.00
Mus musculus
NNDAHWN
NWDTHNN
PBM
Berger et al.(2008)
Irx6_2623
0.790
0.929
ara
M06518_2.00
Drosophila melanogaster
WWACA
TGTWW
B1H
Mathelier et al.(2014)
MA0210.1
0.788
0.929
ara
M06313_2.00
Drosophila melanogaster
TGTWWWNN
NNWWWACA
B1H
Zhu et al.(2011)
Ara_Cell_FBgn0015904
0.788
0.929
ara
M06314_2.00
Drosophila melanogaster
DWWACA
TGTWWH
B1H
Zhu et al.(2011)
Ara_SOLEXA_FBgn0015904
0.788
0.929
caup
M06519_2.00
Drosophila melanogaster
WAACA
TGTTW
B1H
Mathelier et al.(2014)
MA0217.1
0.780
0.893
caup
M06315_2.00
Drosophila melanogaster
HWDWAACA
TGTTWHWD
B1H
Zhu et al.(2011)
Caup_Cell_FBgn0015919
0.780
0.893
caup
M06316_2.00
Drosophila melanogaster
NDDACA
TGTHHN
B1H
Zhu et al.(2011)
Caup_SOLEXA_FBgn0015919
0.780
0.893
Irx2
M00386_2.00
Mus musculus
NNDACAHNN
NNDTGTHNN
PBM
Berger et al.(2008)
Irx2_0900
0.780
0.893
Irx5
M00455_2.00
Mus musculus
NNNDACAHN
NDTGTHNNN
PBM
Berger et al.(2008)
Irx5_2385
0.780
0.893
IRX2
M03212_2.00
Homo sapiens
NDACAYRACAHN
NDTGTYRTGTHN
SELEX
Jolma et al.(2013)
IRX2_1
0.780
0.893
IRX5
M03222_2.00
Homo sapiens
NDACAYRACAHN
NDTGTYRTGTHN
SELEX
Jolma et al.(2013)
IRX5_1
0.780
0.893
IRX5
M05315_2.00
Homo sapiens
NBDTGTHNDACAYVN
NBRTGTHNDACAHVN
SELEX
Yin et al.(2017)
IRX5_eDBD_HT-SELEX
0.780
0.893
IRX5
M05316_2.00
Homo sapiens
WYRYGHHNHAYRYRY
RYRYRTDNDDCRYRW
SELEX
Yin et al.(2017)
IRX5_eDBD_Methyl-HT-SELEX
0.780
0.893
For this family, TFs with SR scores >
0.599
will likely have a similar motif
Experimental Constructs
Motif ID
Domain
From
To
Sequence
M00416_2.00
Homeodomain
18
76
TRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKK
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSMUSP00000022095
Homeodomain
145
203
TRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKK
ENSMUSP00000134738
Homeodomain
145
203
TRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKK
Links
Other
Homeodomain
family TFs
Other
Mus musculus
TFs
390 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy