CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Six3
(
Mus musculus
)
Homeodomain
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00046 (Homeobox)
IPR001356
ENSMUSG00000038805
T212499_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and transcription corepressor binding activity. Involved in several processes, including animal organ development; lens fiber cell apoptotic process; and neuroblast migration. Acts upstream of or within several processes, including animal organ development; circadian behavior; and protein import into nucleus. Located in nucleus. Is expressed in several structures, including embryo ectoderm; limb; maxillary process; nervous system; and sensory organ. Used to study holoprosencephaly 2. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 2. Orthologous to human SIX3 (SIX homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Six3
M00483_2.00
Mus musculus
NNNAYMN
NKRTNNN
PBM
Berger et al.(2008)
Six3_1732
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
SIX3
M05159_2.00
Homo sapiens
NNYGATABBN
NVVTATCRNN
SELEX
Yin et al.(2017)
SIX3_eDBD_HT-SELEX
0.867
1.000
SIX3
M10698_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SIX3_Q6
0.867
1.000
SIX3
M05160_2.00
Homo sapiens
NNYGATABVB
VBVTATCRNN
SELEX
Yin et al.(2017)
SIX3_eDBD_Methyl-HT-SELEX
0.867
1.000
Optix
M02124_2.00
Drosophila melanogaster
NNNNNDATMN
NKATHNNNNN
PBM
Weirauch et al.(2014)
pTH5437
0.867
0.947
Optix
M03850_2.00
Drosophila melanogaster
TAATYTAATTA
TAATTARATTA
SELEX
Nitta et al.(2015)
Optix_1
0.867
0.947
Optix
M06526_2.00
Drosophila melanogaster
TGATA
TATCA
B1H
Mathelier et al.(2014)
MA0199.1
0.867
0.947
Optix
M06327_2.00
Drosophila melanogaster
HHVTGATA
TATCABDD
B1H
Zhu et al.(2011)
Optix_Cell_FBgn0025360
0.867
0.947
Optix
M06328_2.00
Drosophila melanogaster
NNNTGATA
TATCANNN
B1H
Zhu et al.(2011)
Optix_SOLEXA_FBgn0025360
0.867
0.947
SIX6
M00326_2.00
Homo sapiens
NNDATMB
VKATHNN
PBM
Barrera et al.(2016)
SIX6_REF
0.865
0.982
Six6
M00169_2.00
Mus musculus
NNAYMNN
NNKRTNN
PBM
Badis et al.(2009)
Six6_2267
0.865
0.982
Six6
M00412_2.00
Mus musculus
NNNTGATAYCN
NGRTATCANNN
PBM
Berger et al.(2008)
Six6_2267
0.865
0.982
SIX6
M05357_2.00
Homo sapiens
NNYGATASVB
VBSTATCRNN
SELEX
Yin et al.(2017)
SIX6_eDBD_HT-SELEX
0.865
0.982
SIX6
M00325_2.00
Homo sapiens
NNNDATMB
VKATHNNN
PBM
Barrera et al.(2016)
SIX6_H141N
0.865
0.982
SIX6
M05358_2.00
Homo sapiens
VBVYAYCRNN
NNYGRTRBVB
SELEX
Yin et al.(2017)
SIX6_eDBD_Methyl-HT-SELEX
0.865
0.982
six3
M02102_2.00
Oryzias latipes
NNDAYMBNNN
NNNVKRTHNN
PBM
Weirauch et al.(2014)
pTH5928
0.865
0.947
SIX6
M00327_2.00
Homo sapiens
NHDAYMBNN
NNVKRTHDN
PBM
Barrera et al.(2016)
SIX6_T165A
0.859
0.965
For this family, TFs with SR scores >
0.599
will likely have a similar motif
Experimental Constructs
Motif ID
Domain
From
To
Sequence
M00483_2.00
Homeodomain
16
72
EQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRA
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSMUSP00000125169
Homeodomain
208
264
EQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRA
ENSMUSP00000135312
Homeodomain
208
264
EQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRA
ENSMUSP00000135677
Homeodomain
208
264
EQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRA
Links
Other
Homeodomain
family TFs
Other
Mus musculus
TFs
297 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy