CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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hth
(
Drosophila melanogaster
)
Homeodomain
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00046 (Homeobox)
IPR001356
FBgn0001235
T217428_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in several processes, including animal organ development; positive regulation of cell proliferation involved in compound eye morphogenesis; and specification of segmental identity, antennal segment. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including Malpighian tubule; anterior-posterior subdivision of organism; germ layer; imaginal disc; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in cleft palate, cardiac defects, and intellectual disabillity. Orthologous to several human genes including MEIS1 (Meis homeobox 1) and MEIS2 (Meis homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
hth
M06252_2.00
Drosophila melanogaster
TGTCA
TGACA
B1H
Zhu et al.(2011)
Hth_Cell_FBgn0001235
(Direct)
(Direct)
hth
M06253_2.00
Drosophila melanogaster
NNTGACAD
HTGTCANN
B1H
Zhu et al.(2011)
hth_SOLEXA_2_FBgn0001235
(Direct)
(Direct)
hth
M06254_2.00
Drosophila melanogaster
NTGACA
TGTCAN
B1H
Zhu et al.(2011)
Hth_SOLEXA_FBgn0001235
(Direct)
(Direct)
hth
M06490_2.00
Drosophila melanogaster
TGACAK
MTGTCA
B1H
Mathelier et al.(2014)
MA0227.1
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Meis2
M00437_2.00
Mus musculus
NTGACANNN
NNNTGTCAN
PBM
Berger et al.(2008)
Mrg1_2246
0.867
0.964
MEIS2
M03147_2.00
Homo sapiens
WTGACAGSTGTCAM
KTGACASCTGTCAW
SELEX
Jolma et al.(2013)
MEIS2_1
0.867
0.964
MEIS2
M03148_2.00
Homo sapiens
DTGACAGS
SCTGTCAH
SELEX
Jolma et al.(2013)
MEIS2_2
0.867
0.964
Meis2
M03261_2.00
Mus musculus
NTGACAN
NTGTCAN
SELEX
Jolma et al.(2013)
Meis2_1
0.867
0.964
Meis2
M03262_2.00
Mus musculus
TGACAGSTGTCA
TGACASCTGTCA
SELEX
Jolma et al.(2013)
Meis2_2
0.867
0.964
MEIS2
M02740_2.00
Homo sapiens
TGACASSTGTC
GACASSTGTCA
SELEX
Jolma et al.(2010)
MEIS2_dimer
0.867
0.964
MEIS2
M02741_2.00
Homo sapiens
GGACAKNT
ANMTGTCC
SELEX
Jolma et al.(2010)
MEIS2_monomer
0.867
0.964
MEIS2
M05138_2.00
Homo sapiens
TGACASSTGTCA
TGACASSTGTCA
SELEX
Yin et al.(2017)
MEIS2_eDBD_HT-SELEX
0.867
0.964
MEIS2
M05140_2.00
Homo sapiens
TGACASSTGTCA
TGACASSTGTCA
SELEX
Yin et al.(2017)
MEIS2_FL_HT-SELEX
0.867
0.964
MEIS2
M09143_2.00
Homo sapiens
HTGACAGBTKTBM
KVAMAVCTGTCAD
Misc
Kulakovskiy et al.(2013)
MEIS2_HUMAN.H11MO.0.B
0.867
0.964
Meis2
M09189_2.00
Mus musculus
HTGACAGBTKTBM
KVAMAVCTGTCAD
Misc
Kulakovskiy et al.(2013)
MEIS2_MOUSE.H11MO.0.B
0.867
0.964
MEIS2
M05139_2.00
Homo sapiens
YGACASSYGHCR
YGDCRSSTGTCR
SELEX
Yin et al.(2017)
MEIS2_eDBD_Methyl-HT-SELEX
0.867
0.964
MEIS2
M05141_2.00
Homo sapiens
TGACASSTGTCA
TGACASSTGTCA
SELEX
Yin et al.(2017)
MEIS2_FL_Methyl-HT-SELEX
0.867
0.964
Meis1
M00407_2.00
Mus musculus
NTGACADNN
NNHTGTCAN
PBM
Berger et al.(2008)
Meis1_2335
0.835
0.945
Meis3
M00488_2.00
Mus musculus
NTGACANNN
NNNTGTCAN
PBM
Berger et al.(2008)
Mrg2_2302
0.835
0.945
MEIS1
M03165_2.00
Homo sapiens
NTGACAN
NTGTCAN
SELEX
Jolma et al.(2013)
MEIS1_1
0.835
0.945
Meis3
M03279_2.00
Mus musculus
NTGACAN
NTGTCAN
SELEX
Jolma et al.(2013)
Meis3_1
0.835
0.945
Meis3
M03280_2.00
Mus musculus
TGACAGSTGTCA
TGACASCTGTCA
SELEX
Jolma et al.(2013)
Meis3_2
0.835
0.945
MEIS1
M09148_2.00
Homo sapiens
NTGATTDATDDB
VHHATHAATCAN
Misc
Kulakovskiy et al.(2013)
MEIS1_HUMAN.H11MO.0.A
0.835
0.945
Meis1
M09178_2.00
Mus musculus
NTGATTDATDDB
VHHATHAATCAN
Misc
Kulakovskiy et al.(2013)
MEIS1_MOUSE.H11MO.0.A
0.835
0.945
Meis1
M09568_2.00
Mus musculus
VBTGWCASNN
NNSTGWCAVB
Misc
Heinz et al.(2010)
MastCells-Meis1_GSE48085
0.835
0.945
MEIS1
M10709_2.00
Homo sapiens
NHNTGACAGNDN
NHNCTGTCANDN
Transfac
Matys et al.(2006)
V$MEIS1_01
0.835
0.945
MEIS1
M10710_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MEIS1_06
0.835
0.945
unc-62
M02185_2.00
Caenorhabditis elegans
NHDAHANNN
NNNTDTHDN
PBM
Weirauch et al.(2014)
pTH5781
0.778
0.818
Pknox1
M00399_2.00
Mus musculus
HGACRNNN
NNNYGTCD
PBM
Berger et al.(2008)
Pknox1_2364
0.751
0.727
Pknox2
M00468_2.00
Mus musculus
NNNGACRNNN
NNNYGTCNNN
PBM
Berger et al.(2008)
Pknox2_3077
0.751
0.727
PKNOX1
M03178_2.00
Homo sapiens
TGACAGSTGTCA
TGACASCTGTCA
SELEX
Jolma et al.(2013)
PKNOX1_1
0.751
0.727
PKNOX2
M03195_2.00
Homo sapiens
TGACAGSTGTCA
TGACASCTGTCA
SELEX
Jolma et al.(2013)
PKNOX2_1
0.751
0.727
Pknox2
M03270_2.00
Mus musculus
TGACAGSTGTCA
TGACASCTGTCA
SELEX
Jolma et al.(2013)
Pknox2_1
0.751
0.727
PKNOX1
M05206_2.00
Homo sapiens
TGACASSTGTCA
TGACASSTGTCA
SELEX
Yin et al.(2017)
PKNOX1_eDBD_HT-SELEX
0.751
0.727
PKNOX1
M05208_2.00
Homo sapiens
TGACAGCTGTCA
TGACAGCTGTCA
SELEX
Yin et al.(2017)
PKNOX1_FL_HT-SELEX
0.751
0.727
PKNOX2
M05246_2.00
Homo sapiens
TGACABVTGTCA
TGACABVTGTCA
SELEX
Yin et al.(2017)
PKNOX2_eDBD_HT-SELEX
0.751
0.727
PKNOX1
M09150_2.00
Homo sapiens
TGABTGRCRGV
BCYGYCAVTCA
Misc
Kulakovskiy et al.(2013)
PKNX1_HUMAN.H11MO.0.B
0.751
0.727
Pknox1
M09175_2.00
Mus musculus
TGABTGRCRGV
BCYGYCAVTCA
Misc
Kulakovskiy et al.(2013)
PKNX1_MOUSE.H11MO.0.A
0.751
0.727
PKNOX1
M10712_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PREP1_Q3
0.751
0.727
PKNOX1
M05207_2.00
Homo sapiens
YGWCASSTGWCR
YGWCASSTGWCR
SELEX
Yin et al.(2017)
PKNOX1_eDBD_Methyl-HT-SELEX
0.751
0.727
PKNOX1
M05209_2.00
Homo sapiens
TGACABVTGTCA
TGACABVTGTCA
SELEX
Yin et al.(2017)
PKNOX1_FL_Methyl-HT-SELEX
0.751
0.727
PKNOX2
M05247_2.00
Homo sapiens
TGACASSTGTCA
TGACASSTGTCA
SELEX
Yin et al.(2017)
PKNOX2_eDBD_Methyl-HT-SELEX
0.751
0.727
achi
M03860_2.00
Drosophila melanogaster
TGACAD
HTGTCA
SELEX
Nitta et al.(2015)
achi_1
0.657
0.545
achi
M03861_2.00
Drosophila melanogaster
TGACAGMTGTCA
TGACAKCTGTCA
SELEX
Nitta et al.(2015)
achi_2
0.657
0.545
achi
M03862_2.00
Drosophila melanogaster
TGACAGNNNNNNYGTCA
TGACRNNNNNNCTGTCA
SELEX
Nitta et al.(2015)
achi_3
0.657
0.545
vis
M03859_2.00
Drosophila melanogaster
TGACAS
STGTCA
SELEX
Nitta et al.(2015)
vis_1
0.657
0.545
vis
M06534_2.00
Drosophila melanogaster
TGACAB
BTGTCA
B1H
Mathelier et al.(2014)
MA0252.1
0.657
0.545
achi
M06535_2.00
Drosophila melanogaster
TGACAG
CTGTCA
B1H
Mathelier et al.(2014)
MA0207.1
0.657
0.545
achi
M06345_2.00
Drosophila melanogaster
TGTCADW
WHTGACA
B1H
Zhu et al.(2011)
Achi_Cell_FBgn0033749
0.657
0.545
achi
M06346_2.00
Drosophila melanogaster
HTGACA
TGTCAD
B1H
Zhu et al.(2011)
Achi_SOLEXA_FBgn0033749
0.657
0.545
vis
M06343_2.00
Drosophila melanogaster
TGTCA
TGACA
B1H
Zhu et al.(2011)
Vis_Cell_FBgn0033748
0.657
0.545
vis
M06344_2.00
Drosophila melanogaster
TGTCAD
HTGACA
B1H
Zhu et al.(2011)
Vis_SOLEXA_FBgn0033748
0.657
0.545
Tgif2
M00521_2.00
Mus musculus
NNTGACANNN
NNNTGTCANN
PBM
Berger et al.(2008)
Tgif2_3451
0.657
0.527
TGIF2
M03123_2.00
Homo sapiens
TGACAGSTGTCA
TGACASCTGTCA
SELEX
Jolma et al.(2013)
TGIF2_1
0.657
0.527
TGIF2
M05032_2.00
Homo sapiens
TGACABVTGTCA
TGACABVTGTCA
SELEX
Yin et al.(2017)
TGIF2_eDBD_HT-SELEX
0.657
0.527
TGIF2
M05034_2.00
Homo sapiens
DTGACANN
NNTGTCAH
SELEX
Yin et al.(2017)
TGIF2_FL_HT-SELEX
0.657
0.527
TGIF2
M05033_2.00
Homo sapiens
TGWCABVTGWCA
TGWCABVTGWCA
SELEX
Yin et al.(2017)
TGIF2_eDBD_Methyl-HT-SELEX
0.657
0.527
TGIF2
M05035_2.00
Homo sapiens
DTGACANN
NNTGTCAH
SELEX
Yin et al.(2017)
TGIF2_FL_Methyl-HT-SELEX
0.657
0.527
Tgif1
M00500_2.00
Mus musculus
NNTGACANNN
NNNTGTCANN
PBM
Berger et al.(2008)
Tgif1_2342
0.624
0.545
TGIF1
M03223_2.00
Homo sapiens
TGACAGCTGTCA
TGACAGCTGTCA
SELEX
Jolma et al.(2013)
TGIF1_1
0.624
0.545
TGIF1
M05317_2.00
Homo sapiens
TGACAGSTGTCA
TGACASCTGTCA
SELEX
Yin et al.(2017)
TGIF1_eDBD_HT-SELEX
0.624
0.545
TGIF1
M09159_2.00
Homo sapiens
TGACAGS
SCTGTCA
Misc
Kulakovskiy et al.(2013)
TGIF1_HUMAN.H11MO.0.A
0.624
0.545
Tgif1
M09211_2.00
Mus musculus
TGACAGBNV
BNVCTGTCA
Misc
Kulakovskiy et al.(2013)
TGIF1_MOUSE.H11MO.0.A
0.624
0.545
TGIF1
M10740_2.00
Homo sapiens
WHNTGACARST
ASYTGTCANDW
Transfac
Matys et al.(2006)
V$TGIF_01
0.624
0.545
TGIF1
M05318_2.00
Homo sapiens
TGACAKVTGTCA
TGACABMTGTCA
SELEX
Yin et al.(2017)
TGIF1_eDBD_Methyl-HT-SELEX
0.624
0.545
For this family, TFs with SR scores >
0.599
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
FBpp0081732
Homeodomain
366
423
QKKRGIFPKVATNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRI
FBpp0081733
Homeodomain
351
408
QKKRGIFPKVATNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRI
Links
Other
Homeodomain
family TFs
Other
Drosophila melanogaster
TFs
791 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy